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2015’s most cited PAIN paper written by Ottawa researchers
February 17, 2016
Could an antiepileptic drug reduce pain after all kinds of surgery? Dr.
Naveen Eipe
and colleagues were awarded Most Cited Paper of 2015 by the journal
PAIN
for their attempt to answer this controversial question. Pregabalin was originally approved by Health Canada to treat epilepsy and generalized anxiety disorder. But later clinical trials and anecdotal evidence found that it could also be used as a painkiller for surgical patients to reduce their need for opioids. However, it wasn’t known whether pregabalin was equally effective for all kinds of surgeries, which can cause different kinds of pain. In a systematic review of 43 randomized controlled trials, the researchers found that pregabalin’s effect on pain is small (10 percent), and mainly restricted to surgeries like spine, joint surgery and amputations. The paper concluded that pregabalin should only be given to some patients undergoing certain procedures.
Co-authors:
Penning, John; Yazdi, Fatemeh; Mallick, Ranjeeta; Turner, Lucy; Ahmadzai, Nadera; Ansari, Mohammed Toseef.
Funders:
The Ottawa Hospital Department of Anesthesiology, The Ottawa Hospital Foundation
About The Ottawa Hospital
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care.
For further information, please contact
Jennifer Ganton
Director, Communications and Public Relations
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73325
Cell: 613-614-5253
jganton@ohri.ca