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Grandmother saved by diagnosis of rare condition
October 6, 2016
Anita Brisson learned that she had a condition called Factor XIII deficiency in 2013. She decided to participate in research that could help other patients with this very rare blood disease.
Anita Brisson was doing her usual chores in her home near Embrun, Ontario in March 2013 when one of the veins in her tongue burst. As her tongue swelled, the 82-year-old started having trouble breathing.
“When I arrived at The Ottawa Hospital, I couldn’t speak,” said Brisson. “I had to respond to questions in writing.”
It wasn’t the first time that she’d had a mysterious injury. Brisson was making meatballs just before Christmas 2009 when the repetitive task of pushing the meat into a spoon broke one of the veins in her arm.
“I had a bump the size of an orange,” she remembered. “It took six months to heal.”
Her condition was a puzzle to Emergency Department staff when she was first seen at the Civic Campus. All her blood tests came back normal, suggesting to hematologist Dr.
Alan Tinmouth
that she had a very rare disease called Factor XIII deficiency.
“Our bodies need Factor XIII to form and maintain blood clots,” said Dr. Tinmouth, who is also a scientist at The Ottawa Hospital and the University of Ottawa. “Mrs. Brisson didn’t have enough of this protein, so blood pooled in her tissues instead.”
While Dr. Tinmouth did tests to diagnose this rare condition, Dr.
Manoj Lalu
, an anesthesiologist and clinical scholar at The Ottawa Hospital, determined that Brisson needed an urgent procedure to help her breathe through her swollen throat. Then, Brisson was sent to the Intensive Care Unit where anesthesia resident Dr. Kira Tone helped care for her. After receiving injections of Factor XIII for four days, her swelling went down and she was able to breathe normally.
Because there was little information on patients like Brisson, Drs. Tinmouth, Lalu and Tone decided to do a
systematic review
of all the literature to find the best ways to detect and treat Factor XIII deficiency. With Brisson’s permission, they also published an
article
on her specific case. She wanted to participate so she could help others with this rare condition.
“I can’t complain,” she said. “There are people who are much worse off than me.”
Today, Brisson is in good health. She reads
le Droit
, takes daily walks and is president of l’Union culturelle des Franco-Ontariennes. Every month a nurse comes to give her another transfusion of Factor XIII, and she continues to be followed by the Ottawa Regional Adult Bleeding Disorders Program.
“I have every confidence in the doctors and staff at The Ottawa Hospital,” said Brisson. “If I wasn’t brought to the Civic Campus, it’s possible that I wouldn’t be here today.”
The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See www.ohri.ca for more information about research at The Ottawa Hospital.
University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
For further information, please contact
Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315
ambuchanan@ohri.ca