Skip over navigation
The Hospital
Research
Support Us
Ottawa Hospital Research Institute
Home
Français
Directions & Maps
Contact Us
About Us
Vision and Strategic Directions
Board Chair and CEO Message
Leadership Team
Annual Reports
Facilities
Research Data Management
Equity, Diversity and Inclusion
Wellness
Our Research
Priorities, Programs and Diseases
Researcher Profiles
National Research Networks
Scientific Publications
Research Awards
Technology Transfer
Industry Sponsored Research
Responsible Innovation
For Students & Fellows
News & Events
Newsroom
Seminars & Events
Career Opportunities
For Patients
News & Events
Home
>
News & Events
>
Newsroom
Bookmark or Share
Display Options
Display Options
+
Increase
/
-
Decrease
font size
High contrast version
Printer-friendly version
Newsroom
Seminars & Events
Newsroom
New research sheds light on molecular pathways involved in resistance to chemotherapy in ovarian cancer cells
November 23, 2011
Research led by
Dr. Benjamin Tsang
is opening up new avenues to fight one of the greatest challenges in ovarian cancer: the development of resistance to the common chemotherapy cisplatin. It has long been known that dysregulation of a protein called p53 plays a key role in chemotherapy resistance, but Dr. Tsang’s new work reveals that another protein called PARC also plays a key role by controlling p53’s location and action inside cells. This research suggests that targeting PARC may offer a novel approach to prevent or reverse the development of chemotherapy resistance. See
Journal of Biological Chemistry
for details.
Another recent paper by Dr. Tsang’s group shows for the first time that a gene called PPM1D also plays a key role in chemotherapy resistance in ovarian cancer cells by disrupting the normal cell death pathway. See
Oncogene
for details.
This research was supported by the Canadian Institute of Health Research, the National Research Foundation of Korea and funded by the Korean Ministry of Education, Science and Technology. All research at OHRI is also supported by The Ottawa Hospital Foundation.