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Unexpected results lead to new breast cancer research direction
April 13, 2016
Dr.
Luc Sabourin
and his team recently found some unexpected results while studying a protein called periostin. Previous studies suggested this protein had a role in supporting tumour progression in a breast cancer model, so Dr. Sabourin and his team thought that if they removed this protein from their animal models, breast cancer growth would be suppressed. However, their study published in
Breast Cancer Research
shows that the absence of the protein did not slow down tumour growth. Instead it changed the nature of the cancer, into a potentially more aggressive form of the HER2-positive subtype. This subtype tends to grow faster and is more likely to spread, but Dr. Sabourin and his team are not sure if it will behave the same way in their animal model. They are currently performing follow-up studies on the effect of this change of subtype and why periostin causes it.
Authors:
R. Sriram, V. Lo, B. Pryce, L. Antonova, A.J. Mears, M. Daneshmand, B. McKay, S.J. Conway, W.J. Muller.
Funders:
Canadian Breast Cancer Foundation, the Cancer Research Society and the Canadian Institute of Health Research, The Ottawa Hospital Foundation.
About The Ottawa Hospital
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care.
About the University of Ottawa
The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
For further information, please contact
Amelia Buchanan
Senior Communication Specialist
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315
ambuchanan@ohri.ca