Scientific Publications Database
Article Title: Metastatic Adenocarcinoma to the Uterine Cervix Versus Primary Cervical AdenocarcinomaAuthors: Djordjevic, Bojana; Busca, Aurelia; Parra-Herran, Carlos
Journal: AJSP-REVIEWS AND REPORTS Volume 23 Issue 2
Date of Publication:2018
Abstract:
Adenocarcinoma metastases to the cervix can originate from the endometrium, the upper mullerian tract, or from extramullerian sites such as the gastrointestinal and pancreatobiliary tract, bladder, breast, lung, or even the salivary gland. In some cases, the metastatic lesions have signetring morphology, infiltrative pattern, and/or extensive lymphovascular spread. In others, however, the distinction between a primary cervical lesion and a metastasis to the cervix is more challenging because metastases may mimic endocervical adenocarcinoma in situ by colonizing the native endocervical mucosa through intraepithelial spread. Careful morphologic interpretation, combined with immunohistochemistry, human papillomavirus molecular testing, and clinical correlation, is required in order to arrive at the correct diagnosis.