Scientific Publications Database

Article Title: Clinical Characteristics Differentiating Uterine Sarcoma and Fibroids
Authors: Chen, Innie; Firth, Bianca; Hopkins, Laura; Bougie, Olga; Xie, Ri-hua; Singh, Sukhbir
Journal: JSLS-JOURNAL OF THE SOCIETY OF LAPAROENDOSCOPIC SURGEONS Volume 22 Issue 1
Date of Publication:2018
Abstract:
Background and Objectives: Uterine fibroids are a common indication for laparoscopy. Unsuspected sarcoma can pose a serious risk if morcellation is used in the procedure. We sought to determine the clinical factors associated with uterine sarcoma compared with uterine fibroids.Methods: We conducted a case-control study of 66 women who had hysterectomy for uterine sarcoma from April 1, 2007, to March 31, 2014. Sixty-six patients who had hysterectomy for fibroids were randomly selected as controls.Results: Women with sarcoma vs women with fibroids, tended to be older (mean +/- SD 62.1 +/- 10.1 vs 46.5 +/- 6.6; P < .0001), were more likely to be postmenopausal (81.8% vs 9.2%; P < .0001), and were more likely to have a history of another nonuterine malignancy (16.7% vs 4.6%; P = .02). Women with sarcoma were more likely to have masses that were subserosal (69.4% vs 34.8%; P < .0001), rather than intramural (11.1% vs 37.0%; P = .01), and to have a solitary rather than multiple uterine mass (56.3% vs 18.5%; P < .0001). They were also more likely to have a history of documented rapid growth (16.7% vs 4.6%; P = .02).Conclusion: Despite limitations in sample size related to infrequency of uterine sarcoma, our results suggest some preoperative clinical differences between women who.