Scientific Publications Database

Article Title: Growth Restriction, Osteopenia, Placental Massive Perivillous Fibrin Deposition With (or Without) Intervillous Histiocytes and Renal Tubular Dysgenesis-An Emerging Complex
Authors: Abdulghani, Sahar; Moretti, Felipe; Nikkels, Peter G. J.; Khung-Savatovsky, Suonavy; Hurteau-Miller, Julie; Grynspan, David
Journal: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY Volume 21 Issue 1
Date of Publication:2018
Abstract:
We describe a case of a pregnancy complicated by early onset asymmetric growth restriction with anhydramnios with termination occurring at 21 weeks. Fetal autopsy showed demineralization of bones and renal tubular dysgenesis. Placental pathology showed features of massive perivillous fibrin deposition and chronic histiocytic intervillositis. We review prior documentation of this association and briefly discuss potential pathogenesis.