Scientific Publications Database

Article Title: Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise
Authors: Aydin, Sibel Z.; Direskeneli, Haner; Merkel, Peter A.
Journal: JOURNAL OF RHEUMATOLOGY Volume 44 Issue 12
Date of Publication:2017
Abstract:
Objective. To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.Methods. A Delphi survey including 99 items was circulated among international experts for 3 rounds.Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.