Scientific Publications Database

Article Title: Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases
Authors: Benchimol, Eric I.; Bernstein, Charles N.; Bitton, Alain; Carroll, Matthew W.; Singh, Harminder; Otley, Anthony R.; Vutcovici, Maria; El-Matary, Wael; Nguyen, Geoffrey C.; Griffiths, Anne M.; Mack, David R.; Jacobson, Kevan; Mojaverian, Nassim; Tanyingoh, Divine; Cui, Yunsong; Nugent, Zoann J.; Coulombe, Janie; Targownik, Laura E.; Jones, Jennifer L.; Leddin, Desmond; Murthy, Sanjay K.; Kaplan, Gilaad G.
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY Volume 112 Issue 7
Date of Publication:2017
Abstract:
OBJECTIVES: The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine national Canadian IBD incidence, prevalence, and trends over time of childhood-onset IBD.METHODS: We identified children <16 years (y) diagnosed with IBD 1999-2010 from health administrative data in five provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec), comprising 79.2% of the Canadian population. Standardized incidence and prevalence were calculated per 100,000 children. Annual percentage change (APC) in incidence and prevalence were determined using Poisson regression analysis. Provincial estimates were meta-analyzed using random-effects models to produce national estimates.RESULTS: 5,214 incident cases were diagnosed during the study period (3,462 Crohn's disease, 1,382 ulcerative colitis, 279 type unclassifiable). The incidence in Canada was 9.68 (95% CI 9.11 to 10.25) per 100,000 children. Incidence was similar amongst most provinces, but higher in Nova Scotia. APC in incidence did not significantly change over the study period in the overall cohort (+2.06%, 95% CI -0.64% to +4.76%). However, incidence significantly increased in children aged 0-5y (+7.19%, 95% +2.82% to +11.56%). Prevalence at the end of the study period in Canada was 38.25 (95% CI 35.78 to 40.73) per 100,000 children. Prevalence increased significantly over time, APC +4.56% (95% CI +3.71% to +5.42%).CONCLUSIONS: Canada has amongst the highest incidence of childhood-onset IBD in the world. Prevalence significantly increased over time. Incidence was not statistically changed with the exception of a rapid increase in incidence in the youngest group of children.