Scientific Publications Database

Article Title: Toxic medications in Leber's hereditary optic neuropathy
Authors: Kogachi, Kaitlin; Ter-Zakarian, Anna; Asanad, Samuel; Sadun, Alfredo; Karanjia, Rustum
Journal: MITOCHONDRION Volume 46
Date of Publication:2019
Abstract:
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder characterized by acute bilateral vision loss. The pathophysiology involves reactive oxygen species (ROS), which can be affected by medications. This article reviews the evidence for medications with demonstrated and theoretical effects on mitochondrial function, specifically in relation to increased ROS production. The data reviewed provides guidance when selecting medications for individuals with LHON mutations (carriers) and are susceptible to conversion to affected. However, as with all medications, the proven benefits of these therapies must be weighed against, in some cases, purely theoretical risks for this unique patient population.