Scientific Publications Database

Article Title: Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta-analysis
Authors: Gandhi, Niket; Krishna, Satheesh; Booth, Christopher M.; Breau, Rodney H.; Flood, Trevor A.; Morgan, Scott C.; Schieda, Nicola; Salameh, Jean-Paul; McGrath, Trevor A.; McInnes, Matthew D. F.
Journal: BJU INTERNATIONAL Volume 122 Issue 5
Date of Publication:2018
Abstract:
The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T-stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of patients with bladder cancer undergoing T-staging MRI to evaluate the diagnostic accuracy using bivariate random-effects meta-analysis. Sub-group analysis was done to explore variability; risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 tool. The search identified 30 studies (5156 patients). Pooled accuracy at multiple T-stage thresholds: T1 vs T2 = sensitivity 87% (95% confidence interval [CI] 82-91), specificity 79% (95% CI 72-85); T-any vs T0 = sensitivity 65% (95% CI 23-92), specificity 90% (95% CI 83-94); T2 vs T3 = sensitivity 83% (95% CI 75-88), specificity 87% (95% CI 78-93); and