Scientific Publications Database
Article Title: Are Anti-2 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case-Control StudyAuthors: Skeith, Leslie; Abou-Nassar, Karim E.; Walker, Mark; Ramsay, Tim; Booth, Ronald; Wen, Shi Wu; Smith, Graeme N.; Rodger, Marc A.
Journal: AMERICAN JOURNAL OF PERINATOLOGY Volume 35 Issue 11
Date of Publication:2018
Abstract:
Background While anti-2 glycoprotein 1 (anti-2GP1) antibody positivity is included in the diagnostic criteria for antiphospholipid syndrome (APS), the association between anti-2GP1 and the obstetrical complications of APS has been inconsistently reported and remains unclear.Objective We completed a case-control study nested within the Canadian Ottawa and Kingston (OaK) Birth Cohort to evaluate the association between anti-2GP1 antibody positivity and placenta-mediated pregnancy complications.Study Design Five hundred cases were randomly selected among pregnant women who experienced any of the following independently adjudicated placenta-mediated pregnancy complications: preeclampsia, placental abruption, late pregnancy loss ( 12 weeks' gestation), and birth of a small-for-gestational age (SGA) infant<10th percentile. Five hundred pregnant women without any placenta-mediated pregnancy complications were selected as controls. Stored blood samples were analyzed for the presence of anti-2GP1 antibodies by enzyme-linked immunosorbent assay.Results Anti-2GP1 immunoglobulin G (IgG) and/or immunoglobulin M (IgM) antibodies in titers20 G/M units (> 99th percentile) were present in 24 of 497 (4.8%) of controls and 33 of 503 (6.6%) of cases. There was no significant difference between cases and controls for the composite outcome of any placenta-mediated pregnancy complications (odds ratio, 1.38, 95% confidence interval [CI], 0.8-2.37, p =0.25).Conclusion Our results call into question the association between anti-2GP1 antibodies and placenta-mediated pregnancy complications, with further research needed.