Scientific Publications Database

Article Title: Current Options and Emerging Biomaterials for Periprosthetic Joint Infection
Authors: Levack, Ashley E.; Cyphert, Erika L.; Bostrom, Mathias P.; Hernandez, Christopher J.; von Recum, Horst A.; Carli, Alberto, V
Journal: CURRENT RHEUMATOLOGY REPORTS Volume 20 Issue 6
Date of Publication:2018
Abstract:
Purpose of Review Infection in the setting of total joint arthroplasty, referred to as periprosthetic joint infection (PJI), is a devastating complication requiring prolonged and costly treatment. The unique environment around an artificial joint and ability of surrounding tissues to sequester bacteria collectively make prevention, diagnosis, and treatment of this condition challenging. In light of the unique pathogenesis of En, this review explores the limitations of contemporary treatments and discusses novel treatment options.Recent Findings Recent advancements in local antibiotic delivery platforms for preventing and treating PR include titanium nanotube arrays, synthetic polymers, resorbable hydrogels, and cyclodextrin-based drug delivery options. In particular, cyclodextrins have facilitated great advancements in other clinical disorders and have demonstrated early promise as a future option in the arena of PJI.Summary Novel treatment modalities for PR optimize the implant surfaces to prevent bacterial biofilm formation or provide prolonged intra-articular antibiotic dosing to eradicate bacteria.