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Reducing bleeding and blood transfusions during pelvic surgery

August 13, 2014

Drs. Rodney Breau, Alan Tinmouth, Dean Fergusson and Franco Momoli have published a study in Transfusion Medicine Reviews that examines the effectiveness of medications to reduce bleeding during pelvic surgery. Surgery in the pelvic area is inherently difficult and may result in heavy bleeding that requires patients to undergo blood transfusions. The authors assessed the safety and efficacy of a class of medications called lysine analogs. Lysine analogs are commonly used during cardiac surgery and are relatively inexpensive. In the current publication, Breau and colleagues evaluated all of the available evidence evaluating lysine analogs during pelvic surgery. They found that this class of medication seems to be safe for patients, while reducing bleeding and blood transfusion requirements. In a previous study, Dr. Breauís team showed that lysine analogs are not commonly used during pelvic surgery and they are now leading a multicenter prospective trial to verify the effect of lysine analogs during bladder cancer surgery.

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The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the universityís Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting research to improve the understanding, prevention, diagnosis and treatment of human disease.

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