Researchers at The Ottawa Hospital are leading nine new projects funded by the Canadian Institutes of Health Research (CIHR) through the most recent operating grant and SPOR innovative clinical trial competitions.

These projects, worth more than $5 million, will advance science and improve health in areas such as autism, acute kidney injury, pregnancy, cardiovascular disease, COVID-19, surgery, mental health and hospital discharge planning.

Our researchers are also co-leading grants administered at other institutions that are worth at least $5 million.

“These research projects will help us provide the best care possible for our patients and community, while advancing science and improving health on a global scale,” said Dr. Duncan Stewart, Executive Vice-President, Research at The Ottawa Hospital and professor at the University of Ottawa.

Successful CIHR Project Grants administered at OHRI

ALbumin To Enhance Recovery after severe Acute Kidney Injury (ALTER-AKI): a multicentre randomized controlled trial - $956,249

• Principal Investigator(s): Edward Clark, Sean M Bagshaw, Jeannie L Callum, Ron Wald
• Co-Investigator(s): Jennifer L Tsang, John G Boyd, Timothy O Ramsay, Dean A Fergusson, Samuel Silver, Alejandro Y Meraz Muñoz, Bram N Rochwerg, Neill K Adhikari, Shannon M Fernando, William Beaubien-Souligny, Emilie Prudence Belley-Côté, Swapnil Hiremath, Rachel Jeong, Josée Bouchard, Rebecca Mathew, Jan Friedrich

Infant and child health outcomes following SARS-CoV-2 infection in pregnancy- $175,000

• Principal Investigator(s): Darine El-Chaâr, Steven Hawken, Jason C Brophy
• Co-Investigator(s): Mark C Walker, William Cameron, Jocelynn L Cook, Daniel J Corsi, Ashraf Kharrat, Katherine A Muldoon, Malia S Murphy, Ryan J Van Lieshout, Robin Ducharme, Sandra I Dunn, Deshayne B Fell, Anne Pham-Huy

Defective endothelial metabolism and mitochondrial biogenesis in autism spectrum disorders - $961,990

• Principal Investigator(s): Baptiste Lacoste
• Co-Investigator(s): Mireille Khacho

REmote cardiac MOnitoring of at-risk SYNCope patients after Emergency Department discharge - A Randomized Controlled Trial: REMOSYNCED- $520,199

• Principal Investigator(s): Venkatesh Thiruganasambandamoorthy
• Co-Investigator(s): Alain Vadeboncoeur, Wadea Tarhuni, Ratika Parkash, Steven C Brooks, Peter Tanuseputro, Eric Mercier, Andrew D Krahn, Monica Taljaard

Multi-Center Implementation of an Educational Program to Improve the Cardiac Arrest Diagnostic Accuracy of Ambulance Telecommunicators and Survival Outcomes for Sudden Cardiac Arrest Victims- $141,526

• Principal Investigator(s): Christian Vaillancourt
• Co-Investigator(s): Katie N Dainty, J. Phillip Nicholson, Judah P Goldstein, Brian E Grunau, Shannon Leduc, Sheldon Cheskes, Matthew N Church, Venkatesh Thiruganasambandamoorthy, James M Christenson, Michael Feldman, Monica Taljaard, Ian Blanchard, Sandra E Jenneson

Piloting the EAGER trial: Expectant management versus induction At 38 weeks among individuals with GEstational diabetes mellitus - a Randomized controlled trial- $ 569,926

• Principal Investigator(s): Mark Walker, Darine El-Chaâr, Elizabeth V Asztalos, Dean A Fergusson, Denice S Feig
• Co-Investigator(s): Malia S Murphy, Erin J Keely, Steven Hawken, Shi Wu Wen, Graeme N Smith, Daniel J Corsi, Katherine A Muldoon, Alysha Harvey, Ruth Rennicks White, Howard Berger, Jocelynn L Cook, Jon Barrett, Kednapa Thavorn, Kellie E Murphy, Laura M Gaudet, Mathew Sermer, Ravi R Retnakaran, Rohan D D'Souza, Francois Audibert, Prakeshkumar Shah, Nir Melamed, Evelyne E Rey, Emmanuel Bujold, Michael E Helewa, Haim A Abenhaim, Kenneth Lim, Stephen L Wood, Christy Pylypjuk

Successful CIHR Project Grants with OHRI PIs - administered at another institution

BRAINapt: TBI International Adaptive Platform Trial - $4,846,275

• Principal Investigator(s): Alexis F Turgeon. Shane William English, François Lauzier, Michelle McDonald, Lynne Moore, Jay Park, Ryan Zarychanski
• Co-Investigator(s): I. Ball. E. Belley-Côté, J. Boyd, K. Burns, M. Bérubé, D. Clarke, F. D'Aragon, A. Docherty, D. Fergusson, R. Fowler, C. Francoeur, R. Green, D. Griesdale, A. Kramer, D. Kutsogiannis, F. Lamontagne, V. Lau Madame, Lessard Bonaventure, L. Malbouisson, J. Marshall, V. McCredie, C. Mcarthur, J. Mejia-Mantilla, D. Menon, A. Nichol, S. Nicholls, J. Rhodes, A. Rigamonti, D. Scales, M. Sekhon, S. Sharma, M. Slessarev, M. St-Onge, E. Sy, L. Terrett, M. Verret, S. Webb, N. Yada, F. Zeiler
• Note: this grant is administered at Université Laval

Psilocybin Assisted Therapy (PAT) for Treatment Resistant Depression in Bipolar II Disorder (TRD.BD-II): A Randomized Controlled Trial - $1,200,076

• Principal Investigator(s): Yatham, Lakshmi N; Ha, Kyooseob; Husain, Muhammad I; Keramatian, Kamyar; Rosenblat, Joshua D; Saraf, Gayatri
• Co-Investigator(s): Aaronson, Scott T; Chakrabarty, Trisha; Fiedorowicz, Jess G; Frangou, Sophia; Hatcher, Simon; Lam, Raymond W; Menon, Mahesh; Michalak, Erin; Solmi, Marco; Torres, Ivan; Williams, Monnica; Wong, Hubert H; Woolley, Joshua
• Note: this grant is administered at the University of British Columbia

Successful CIHR SPOR Innovative Clinical Trial Grants administered at OHRI

Virtual, Innovative, postsurgical Care To Optimize Return home for older people with frailtY: the VICTORY randomized trial - $1,373,804

• Principal Investigator(s): Aucoin, Sylvie D; Forster, Alan J; Kidd, Gurlavine D; Lalu, Manoj M; McIsaac, Daniel I
• Co-Investigator(s): Hladkowicz, Emily

Pilot trial of time restricted eating to support an adaptive innovative clinical trial of combined chronotherapies for mania in bipolar disorder - $191,811

• Principal Investigator(s): Fiedorowicz, Jess G; Saraf, Gayatri; Solmi, Marco; Ward-King, Jessica
• Co-Investigator(s): Audet, Marie-Claude; Dargél, Aroldo A; Robillard, Rébecca

Improving discharges of people experiencing homelessness from hospital: a quality improvement project embedded in a stepped wedge design - $196,807

• Principal Investigator(s): Hatcher, Simon; Forster, Alan J; Van Herk, Kimberley; White, Tracy
• Co-Investigator(s): Fiedorowicz, Jess G; Patel, Rakesh V; Ayonrinde, Oyedeji; Beder, Michaela; Masters, Christina; Nicholls, Stuart G; Ramsay, Timothy O; Simmons, John G

These projects are supported by core resources for research at The Ottawa Hospital, such as the Ottawa Methods Centre.

The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation. Learn more about how research is funded.

Media Contact 

Jenn Ganton

613-614-5253

jganton@ohri.ca