GREGOIRE LE GAL profile picture

Contact Information

GREGOIRE LE GAL, MD, PhD
613-737-8899, ext 73034
glegal@ohri.ca

GREGOIRE LE GAL

Senior Scientist, Clinical Epidemiology Program
Ottawa Hospital Research Institute

Research Interests

Dr. Le Gal's primary research interest is the diagnosis and management of venous thromboembolism (VTE), including the clinical diagnosis of VTE, and the derivation and validation of clinical decision rules for VTE.

Brief Biography

Dr. Grégoire Le Gal, M.D., Ph.D., is a Professor in the Division of Hematology of the Department of Medicine at the University of Ottawa, a physician in the Thrombosis Program, Division of Hematology at Ottawa Hospital, and a Senior Scientist in the Ottawa Hospital Research Institute, Clinical Epidemiology Program since July 2012. He was born and trained in France.

His primary research interest is the diagnosis and management of venous thromboembolism (VTE), including the clinical diagnosis of VTE, and the derivation and validation of clinical decision rules for VTE. He has 185 peer-reviewed publications in general internal medicine and specialized journals and has had multiple international speaking invitations. He is a member of the international advisory board of the Journal of Thrombosis and Haemostasis, and a reviewer for main general internal medicine and thrombosis Journals. He has been the principal investigator of several multicenter multinational projects on the diagnosis and management of VTE. He is currently the Principal Investigator of four peer-reviewed clinical studies (Programme Hospitalier de Recherche Clinique, Ministry of Health, France).

Selected Publications

Castellucci LA, Cameron C, Le Gal G, Rodger MA, Coyle D, Wells PS, Clifford T, Gandara E, Wells G, Carrier M. Clinical and safety outcomes associated with treatment of acute venous thromboembolisme: A systematic review and meta-analysis. JAMA. 2014 Sep;312(11):1122.1135.

Righini M, Van Es J, Den Exter PL, Roy PM, Verschuren F, Ghuysen A, Rutschmann OT, Sanchez O, Jaffrelot M, Trinh-Duc A, Le Gall C, Moustafa F, Principe A, Van Houten AA, Ten Wolde M, Douma RA, Hazelaar G, Erkens PMG, Van Kralingen KW, Grootenboers MJJH, Durian MF, Cheung YW, Meyer G, Bounameaux H, Huisman MV, Kamphuisen PW, Le Gal G. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA. 2014 Mar 19;311(11):1117-24.

Castellucci LA, Cameron C, Le Gal G, Rodger MA, Coyle D, Wells PS, Clifford T, Gandara E, Wells G, Carrier C. Efficacy and safety outcomes of oral anticoagulants and antiplatelet drugs in the secondary prevention of venous thromboembolism: systematic review and network meta-analysis. BMJ. 2013 Aug 30;347:f5133.

Le Gal G, Kercret G, Ben Yahmed K, Bressollette L, Robert-Ebadi H, Riberdy L, Louis P, Delluc A, Labalette ML, Bounameaux H, Mottier D, Righini M. on behalf of the EDVIGE Study Group. Diagnostic value of single complete compression ultrasonography in pregnant and postpartum women with suspected deep vein thrombosis: a prospective outcome study (EDVIGE). BMJ 2012;344: e2635.

Salaun PY, Couturaud F, Le Duc-Pennec A, Lacut K, Le Roux PY, Guillo P, Pennec PY, Cornily JC, Leroyer C, Le Gal G. Non-invasive diagnosis of pulmonary embolism. Chest 2011; 139(6): 1294-8.

Douma RA, Le Gal G, Sohne M, Righini M, Kamphuisen PW, Perrier A, Kruip MJHA, Bounameaux H, Buller HR, Roy PM. Age-adjusted D-dimer cut-off levels increase the ability to safely rule out pulmonary embolism in elderly patients. BMJ 2010; 340(303): c1475.

Righini M, Le Gal G, Aujesky D, Roy PM, Sanchez O, Verschuren F, Rutschmann O, Nonent M, Cornuz J, Thys F, Petit-Le Manach C, Revel MP, Poletti PA, Meyer G, Mottier D, Perneger T, Bounameaux H, Perrier P. Diagnosing Pulmonary Embolism By Multi-Detector Computed Tomography Alone Or Combined With Lower Limb Venous Ultrasonography: A Randomized Non-Inferiority Trial. Lancet 2008; 371(9621):1343-52 

Le Gal G, Righini M, Roy PM, Sanchez O, Aujesky D, Bounameaux H, Perrier A. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med 2006; 144(3): 165-71.

Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, Solymoss S, Crowther M, Perrier A, White R, Vickars L, Ramsay T, Betancourt M and Kovacs MJ. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ 2008; 179 (5): 417-26.

Carrier M, Le Gal G, Wells PS, Fergusson D, Rodger M. Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? Ann Intern Med 2008; 149(5): 323-33.