Scientist, Regenerative Medicine Program
Ottawa Hospital Research Institute
Associate Professor, Departments of Medicine and Biochemistry, Microbiology & Immunology
University of Ottawa
Medical Director, Cord Blood Bank & OneMatch
Canadian Blood Services
Ongoing research addresses the regenerative function of blood-derived vascular progenitor cells, the role of the bone marrow microenvironment in leukeogenesis and the use of mesenchymal stromal cells in regenerative therapy and immune modulation. Research in Dr. Allan’s laboratory has been funded by CIHR, NSERC, Canadian Blood Services, The Ottawa Hospital Foundation and the Department of Medicine.
Dr. Allan is a clinician-researcher with the Blood and Marrow Transplant Program at The University of Ottawa and the Sprott Centre for Stem Cell Research in the Regenerative Medicine Program at The Ottawa Hospital Research Institute. He is a graduate of Queen's University and completed residency in Internal Medicine and Hematology and the University of Toronto and University of Western Ontario. As a post-MD research fellow at Robarts Reseach Institute, he studied the regenerative function of hematopoietic stem cells and he completed a clinical fellowship in blood and marrow transplantation at the Maisonneuve-Rosemont Hospital in Montreal.
Cell-based Regenerative Therapy
1. Damien P*, Allan DS. Use of umbilical cord blood cells in regenerative therapy. Biol Blood Marrow Transplant, 2015; 21:1545-1554. [PMID 26079441]
2. Akyurekli C*, Le Y*, Richardson R, Fergusson D, Tay J, Allan DS. A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles. Stem Cell Rev & Reports, 2015; 11:150-160. [PMID 25091427]
3. Palii C, Vulesevic B, Fraineau S, Pranckeviciene E, Griffith AJ, Chu A, Faralli H, Li Y, McNeill B, Sun J, Perkins TJ, Dilworth FJ, Perez-Iratxeta C, Suuronen EJ+, Allan DS+, Brand M+. Trichostatin A enhances the vascular repair function of injected human endothelial progenitors by increasing the expression of TAL1-dependent genes. Cell Stem Cell, 2014; 14:644-657. [PMID 24792117]
Hematopoietic Stem Cells & Transplantation
4. Le Y*, Fraineau S*, Chandran P*, Brand M, Sabloff M, Richardson R, Allan DS. Adipogenic mesenchymal stromal cells from bone marrow and their hematopoietic supportive role: towards an understanding of a permissive marrow microenvironment in acute myeloid leukemia. Stem Cell Rev & Rep, 2015 (accepted).
5. Chandran P*, Le Y*, Li Y, Sabloff M, Mehic J, Rosu-Myles M, Allan DS. Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors. Leuk Res, 2015; 39:486-493. [PMID 25703353]
Diseases, conditions and populations of interest
Blood cancer; Vascular, heart and metabolic disease
Research and clinical approaches
Cell therapy; Regenerative medicine; Stem cells; Transplantation