Scientist, Neuroscience Program
Ottawa Hospital Research Institute
Assistant Professor, Medicine, Epidemiology and Community Medicine
University of Ottawa
Stroke Neurologist, Medicine, Neurology
Director of Research
Ottawa Stroke Program
1) Intracerebral Hemorrhage (ICH). I am interested in how acute ICH behaviour relates to clinical symptoms and recovery, and how volume, location & morphology can influence early hematoma expansion, ventricular rupture, and final outcome.
2) Neuroimaging & hyper-acute stroke. I believe multi-modal imaging can optimize acute stroke therapy; findings on CTA and CTP can guide therapeutic decision-making, and expand our current treatment windows.
3) Acute stroke therapy. Our group actively participates in multicentre trials of novel therapies for both ischemic stroke and ICH.
Dr. Dowlatshahi is a Stroke Neurologist at the Ottawa Hospital and an Assistant professor in the Department of Medicine, and Cross Appointed to Epidemiology and Community Medicine, University of Ottawa. He is the Scientific Director of the Ottawa Stroke Program and recently promoted to Scientist, Neuroscience, Ottawa Hospital Research Institute. He is also a member of the Faculty of Graduate and Postdoctoral Studies.
Dr. Dowlatshahi obtained his MD and PhD from McMaster University. He then completed a residency in Neurology at the University of Ottawa, followed by a Stroke Fellowship at the University of Calgary. He joined the University of Ottawa and OHRI in July 2010 and is both a Clinician Scientist and the Scientific Director of the Ottawa Stroke Program. In 2014 he was awarded the inaugural Department of Medicine Clinician-Scientist Chair Award, and a Heart & Stroke Foundation of Canada New Investigator Award. His clinical research program in acute stroke and intracerebral hemorrhage focuses on multi-modal neuroimaging. Through collaborative trials and observational studies, Dr. Dowlatshahi hopes to discover a treatment for intracerebral hemorrhage.
, Wasserman JK, Butcher KS, Bernbaum ML, Cwinn AA, Giulivi A, Lang E, Poon MC, Tomchishen-Pope J, Sharma M, Coutts SB. Stroke prenotification is associated with shorter treatment times for warfarin-associated intracerebral hemorrhage. Cerebrovasc Dis. 2013;36(5-6):383-7.
, Wasserman JK, Momoli F, Petrcich W, Stotts G, Hogan M, Sharma M, Aviv RI, Demchuk AM, Chakraborty S; Ottawa Stroke Research Group. Evolution of computed tomography angiography spot sign is consistent with a site of active hemorrhage in acute intracerebral hemorrhage. Stroke. 2014 Jan;45(1):277-80.
Alhazzaa M, Sharma M, Blacquiere D, Stotts G, Hogan M, Dowlatshahi D
. Thrombolysis despite recent stroke: a case series. Stroke. 2013 Jun;44(6):1736-8
, Hogan MJ, Sharma M, Stotts G, Blacquiere D, Chakraborty S.Ongoing bleeding in acute intracerebral haemorrhage. Lancet. 2013 Jan;381(9861):152.
, Kosior JC, Idris S, Eesa M, Dickhoff P, Joshi M, Subramaniam S, Tymchuk S, Hill MD, Aviv RI, Frayne R, Demchuk AM. Planimetric hematoma measurement in patients with intraventricular hemorrhage: is total volume a preferred target for reliable analysis? Stroke. 2012 Jul;43(7):1961-3.
, Butcher KS, Asdaghi N, Nahirniak S, Bernbaum ML, Giulivi A, Wasserman JK, Poon MC, Coutts SB. Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal. Stroke. 2012 Jul;43(7):1812-7.
Demchuk AM, Dowlatshahi D
, Rodriguez-Luna D, Molina CA, Blas YS, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Kosior J, Bhatia R, Tymchuk S, Subramaniam S, Gladstone DJ, Hill MD, Aviv RI. Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurol. 2012 Apr;11(4):307-14.
, Demchuk AM, Flaherty ML, Ali M, Lyden PL, Smith EE. Defining hematoma expansion in intracerebral hemorrhage: relationship with patient outcomes. Neurology. 2011 Apr 5;76(14):1238-44.