Are EVs travelling to injured lungs?
March 15, 2024 - Tiny particles called extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have shown clear potential to treat several lung diseases in animal models by reducing inflammation. However, there has been debate about where MSC-EVs ... |
Powering up the body’s EVs
November 9, 2023 - Dr. Alvin Tieu is receiving the Worton Researcher in Training Award from The Ottawa Hospital for his multidisciplinary research on life-threatening lung diseases |
Novel stem cell drives ‘remarkable’ regeneration of tiny blood vessels in the lung
May 15, 2023 - Dr. Duncan Stewart’s team has identified a novel stem cell with a remarkable ability to regenerate and repair the tiny blood vessels in the lungs. |
Study could lead to new treatments for pulmonary hypertension and right heart failure
February 28, 2023 - The human heart has a remarkable ability to adapt and compensate in the face of injury and disease, but unfortunately this isn’t universal. |
Clinical trial will test promising cell therapy for septic shock
January 19, 2023 - Dr. Lauralyn McIntyre was awarded $1.6 million from the Canadian Institutes of Health Research Clinical Trials Fund to conduct a Phase II clinical trial of mesenchymal stem cells (MSCs) in patients with septic shock. |
Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million
July 20, 2022 - These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, ... |
Researchers at The Ottawa Hospital awarded five grants for high risk, high reward and interdisciplinary research
April 4, 2022 - The New Frontiers in Research Fund (NFRF) 2021 Exploration competition has awarded $25 million to support 102 research teams across Canada that bring diverse disciplines together in pursuit of breakthrough ideas and high-reward outcomes. |
Tiny particles hold promise for treating acute and chronic lung disease
February 17, 2022 - A meta-analysis of lab studies found that tiny particles called extracellular vesicles (EVs) released by mesenchymal stem/stromal cells (MSCs) have clear potential for treating acute lung injury, |
Medicine’s future: living drugs
November 19, 2021 - The Ottawa Hospital’s Biotherapeutics Manufacturing Centre harnessing the life-saving power of biological therapies |
Biotherapeutics: the future of medicine
May 25, 2021 - World-class biotherapeutics facility at The Ottawa Hospital uses cells, genes and viruses to create unique life-saving treatments |
Grateful COVID-19 patient gives back by participating in research
April 13, 2021 - Sharon Charlebois doesn’t remember much about the 25 days she spent at The Ottawa Hospital fighting a severe case of COVID-19 in January 2021. Now that she’s recovering at home with her husband, some memories come back to her in flashes. |
The rise of point-of-care cell manufacturing
March 12, 2021 - Decentralized approach represents a paradigm shift in the way Canada studies, commercializes and delivers stem cell treatments for serious diseases |
Experimental stem cell therapy a potential weapon against COVID-19
February 1, 2021 - Drs. Duncan Stewart, Shane English, Dean Fergusson and colleagues have launched a clinical trial to test MSCs in people with severe COVID-19. |
$1M grant to support manufacturing of COVID-19 treatments and vaccines at The Ottawa Hospital and uOttawa
November 6, 2020 - Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $1,050,000 from the Canada Foundation for Innovation to support facilities for manufacturing innovative treatments and vaccines for COVID-19. |
The Ottawa Hospital awarded $4.7 million for COVID-19 research from the Canadian Institutes of Health Research
June 25, 2020 - Researchers at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded $4.7 million from the Canadian Institutes of Health Research (CIHR) for four research projects that could transform our understanding of COVID-19 and ... |
Creating a new mouse model to study COVID-19 lung disease
June 4, 2020 - Researchers are working to develop a mouse model of COVID-19 that mimics the severe lung disease seen in humans. The lack of good, accessible animal models of this disease is severely limiting research around the world. |
Experimental Stem Cell Therapy a Potential Weapon in COVID-19 Fight
May 28, 2020 - Ottawa-based researchers pivot at lightning speed to launch study on treating related respiratory failure |
COVID-19 research on cell therapy, drug screening and marginalized populations funded through Ontario’s Rapid Research Fund
May 21, 2020 - Researchers from The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded almost $2 million from Ontario’s COVID-19 Rapid Research Fund for three research projects that could help in the fight against the virus. These ... |
Harnessing stem cells and regenerative medicine to fight COVID-19
April 23, 2020 - Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $490,000 from the Stem Cell Network for two research projects that could help in the fight against COVID-19. These peer-reviewed grants are part of an overall ... |
Top Research Papers from The Ottawa Hospital 2015-2017
June 7, 2018 - Did you know that researchers at The Ottawa Hospital publish an average of four new scientific papers every single day? Our research is advancing science and improving health on a massive scale – both at home and around the world. The list below ... |
Patent brings possible new heart failure treatment closer to reality
May 30, 2018 - Drs. Lynn Megeney, Duncan Stewart, Colin Suen, and Mohammad Abdul-Ghani have been granted a U.S. patent for an experimental approach to treat heart failure using a protein called cardiotrophin 1 (CT1). Heart failure is a leading cause of death ... |
New research could explain why cells grow out of control in rare lung disease
May 9, 2018 - When cells grow out of control in the body, most people think of cancer, but this phenomenon also occurs in pulmonary arterial hypertension (PAH), a rare and deadly disease characterized by very high pressure in the arteries that supply blood to th |
Experimental stem cell therapy tested for rare lung disease
April 30, 2018 - A Canadian-led research team has launched a clinical trial of an experimental stem cell therapy for pulmonary arterial hypertension. This rare and deadly disease occurs when the arteries that supply blood to the lungs become so damaged that blood ... |
Could stem cells repair the heart, fight infections, mend premature lungs, and heal the brain after stroke?
April 11, 2018 - Ottawa researchers closer to finding out, thanks to $999,900 from the Stem Cell Network
Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks |
Stem cells for septic shock: world-first trial establishes safety, sets stage for larger trial
November 2, 2017 - Stem cells are usually thought of as the building blocks of the body – able to give rise to all our cells and organs. But Dr. Lauralyn McIntyre, Dr. Duncan Stewart, Dr. Dean Fergusson and their colleagues are testing the idea that certain stem ... |
How to trick your heart into thinking you exercise: cardiotrophin improves heart health and repairs damage in lab models
August 4, 2017 - Researchers have discovered that a protein called cardiotrophin 1 (CT1) can trick the heart into growing in a healthy way and pumping more blood, just as it does in response to exercise and pregnancy. They show that this good kind of heart growth i |
The Ottawa Hospital welcomes new stem cell research report and alliance
March 9, 2017 - A new workshop report, Building on Canada’s Strengths in Regenerative Medicine, released today by the Council of Canadian Academies (CCA), confirms that Canadian researchers continue to be recognized as scientific leaders in the field of ... |
Three Ottawa-led stem cell trials get $2.2 million boost
November 23, 2016 - Ottawa researchers bring in half of clinical trial awards from Stem Cell Network
Could stem cells help the body recover from septic shock, heart attack and liver transplantation? Researchers from The Ottawa Hospital and the University of Ottawa |
$4.2M grant to advance development of next-generation regenerative therapies for vascular disease
July 13, 2016 - Dr. Duncan Stewart has been awarded $4.2M from the Canadian Institutes of Health Research (CIHR) to advance our understanding of vascular disease and develop next-generation regenerative therapies. Dr. Stewart and his team have already initiated |
$270,000 grant to help researchers discover if a heart-growth protein can halt some heart disease
July 6, 2016 - Dr. Lynn Megeney, in collaboration with Dr. Duncan Stewart, has been awarded $270,000 from the Heart and Stroke Foundation of Canada to investigate how a protein can trigger beneficial growth in heart muscle. The heart can temporarily grow in siz |
Ottawa researchers shine in SPOR funding announcement
April 12, 2016 - Researchers from The Ottawa Hospital are playing a lead role in two of the five chronic disease networks recently funded by Canada's Strategy for Patient-Oriented Research (SPOR), managed by the Canadian Institutes for Health Research. Dr. Patric |
Man survives severe infection after participating in world-first stem cell trial at The Ottawa Hospital
March 31, 2016 - Stem cells are usually thought of as the building blocks of the body – able to give rise to all our cells and organs. But a clinical trial at The Ottawa Hospital is testing the idea that certain stem cells may also be able to help control the body’s |
Ottawa researchers answer patient questions about stroke and stem cells
February 10, 2016 - Drs. Duncan Stewart, Dar Dowlatshahi and Dale Corbett help answer patient questions about stroke and stem cells in a new video from the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery. The video describes the need for further res |
Stem cell therapy shows promise in small clinical trial for rare lung disease
July 20, 2015 - Canadian researchers have published promising results of the first clinical trial in the world of a genetically-enhanced stem cell therapy for pulmonary arterial hypertension (PAH).
This rare and deadly disease mainly affects young women, and i |
Ottawa stem cell scientist helps patients separate hope from hype
April 17, 2015 - Did hockey legend Gordie Howe experience a miraculous recovery from a stroke after receiving stem cell treatment in Mexico? What therapy did he receive, and was this done as part of a rigorous research study, or was it unscrupulous stem cell tourism? |
Ottawa Hospital researchers to lead new national respiratory and vascular networks
February 24, 2014 - Ottawa, Canada — Researchers from The Ottawa Hospital and the University of Ottawa are leading two of three national health research networks announced today at The Ottawa Hospital by Canada’s Minister of Health, the Honourable Rona Ambrose. The Cana |
First patient treated in groundbreaking stem cell therapy trial for heart attack
September 5, 2013 - Ottawa, Canada — Canadian researchers have treated the first patient in a world-first clinical trial using genetically enhanced stem cells to repair damaged heart muscle after a major heart attack. The formal name of the trial is ENACT-AMI, which sta |
Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
March 15, 2012 - A team of researchers from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) has been awarded $367,000 from the Canadian Institutes of Health Research (CIHR) and $75,000 from the Stem Cell Network to lead the first |
Top researchers gather in Ottawa to advance the development of stem cell therapies for cardiovascular disease
February 13, 2012 - Approximately 45 leading stem cell researchers from Ottawa and Toronto gathered at the Canadian Museum of Nature today to present and discuss their latest work in developing stem cell therapies for cardiovascular disease.
The meeting is part of th |
