John Woulfe profile picture

Contact Information

John Woulfe, PhD, MD
613-798-5555 ext. 13345
jwoulfe@toh.on.ca

501 Smyth Road
Ottawa, ON K1H 8L6

John Woulfe

Associate Scientist, Neuroscience Program
Ottawa Hospital Research Institute
Attending Staff Neuropathologist, Department of Laboratory Medicine
Ottawa Hospital, Civic Campus
Assistant Professor, Department of Pathology
University of Ottawa

Research Interests

Dr. Woulfe's research interests center on the role of alpha-synuclein aggregation in the pathophysiology of Parkinson's disease. In collaboration with Dr. Doug Gray, he is creating a novel mouse model which will allow the direct visualization of alpha-synuclein aggregation in Vivo. This tool will be used to explore environmental triggers that might initiate Parkinson's disease.

Brief Biography

Dr. Woulfe is Staff Neuropathologist at the Ottawa Hospital, Associate Professor at the University of Ottawa, and Associate Scientist at the OHRI in the Center for Cancer Therapeutics.

Selected Publications

Gray M, Munoz DG, Schlossmacher M, Gray DA, Woulfe J. α-synuclein in the appendiceal mucosal plexus and macrophages of neurologically healthy subjects: implications for Parkinson’s disease initiation. Movement Disorders 2014;29(8):991-998. *Winner of Best Paper of the Year Award from Movement Disorders for 2014.

Dos Santos MP;Martin J;Woulfe J;Lim SP;Chakraborty S;, (2014 Jan), Autopsy-proven Acute Hemorrhagic Leukoencephalitis in an Elderly Patient, Can J Neurol Sci , Vol.41, Issue 1, 99-102

Shankar JJ;Woulfe J;Silva VD;Nguyen TB;, (2013 May), Evaluation of perfusion CT in grading and prognostication of high-grade gliomas at diagnosis: a pilot study, AJR Am J Roentgenol, Vol.200, Issue 5, W504-W509

McDonell LM;Mirzaa GM;Alcantara D;Schwartzentruber J;Carter MT;Lee LJ;Clericuzio CL;Graham JM;Morris-Rosendahl DJ;Polster T;Acsadi G;Townshend S;Williams S;Halbert A;Isidor B;David A;Smyser CD;Paciorkowski AR;Willing M;Woulfe J;Das S;Beaulieu CL;Marcadier, (2013 May), Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome, Nat Genet, Vol.45, Issue 5, 556-562

Sinha N;Grimes D;Tokuhiro S;Sato C;Rogaeva E;Woulfe J;, (2013 Mar), Variant Alzheimer's disease with spastic paraparesis and supranuclear gaze palsy, Can J Neurol Sci, Vol.40, Issue 2, 249-251

Milman P;Woulfe J;, (2013 Jun 8), A novel variant of neuronal intranuclear rodlet immunoreactive for 40 kDa huntingtin associated protein and ubiquitin in the mouse brain, J Comp Neurol, Vol.521, Issue 16, 3832-3846

Diseases, conditions and populations of interest


Brain and neuromuscular disease; Brain cancer; Cancer; Parkinson's



Research and clinical approaches


Basic research; Clinical research; Translational research