Lauralyn McIntyre
Senior Scientist, Acute Care Research
Ottawa Hospital Research Institute
Physician, Critical Care
The Ottawa Hospital
Associate Professor, Department of Medicine
University of Ottawa
Research Interests
Dr. Lauralyn McIntyre's program of research is focused on fluid
resuscitation strategies in the critically ill (FLUID) as well as a program to
study human stem cells in septic shock (CISS). She has conducted observational studies, surveys, meta-analyses and clinical trials that examine fluid resuscitation in the septic shock setting, as well as the use of red blood cells, fresh frozen plasma and transfusion alternatives in the critically ill.
Brief Biography
Dr. McIntyre is an Intensivist with a background in Internal Medicine and a Clinical
Epidemiologist at the University of Ottawa. She is a Senior Scientist at the
Ottawa Hospital Research Institute and an Associate Professor in the Department
of Medicine (DOM) at the University of Ottawa. She is the Director of Critical
Care research since 2007 and a member of the Research Advisory Committee with
the DOM at the Ottawa Hospital since 2009. Nationally, I have Co-Chaired the
Grants and Manuscripts Committee (2012-17) and have been a member of the
Executive Committee with the Canadian Critical Care Trials Group (CCCTG)
(2011-17).
Selected Publications
McIntyre L, Fergusson D, McArdle T, English
S, Cook DJ, Fox-Robichaud AE, Martin C, Marshall J, Pugliese M, Menon K,
Thavorn K, Graham ID, Hawken S, Iyengar A, Kyeremanteng K, Saginur R, Seely
AJE, Stiell IG, Bainbridge D, Weijer C, Taljaard M; Canadian Critical Care
Trials Group. A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution
versus Normal Saline. N Engl J Med. 2025 Jun 12. doi:
10.1056/NEJMoa2416761. Online ahead of print.
Terrett LA, Reszel J, Ameri S, Turgeon AF,
McIntyre
L, English SW. Elevated Blood Pressure and Culprit Aneurysm Rebleeding
During the Unsecured Period of Aneurysmal Subarachnoid Hemorrhage: A Systematic
Review. Neurocrit Care. 2024 Oct 14. doi: 10.1007/s12028-024-02138-4.
Online ahead of print.
Terrett LA,
McIntyre L, O'Kelly C, Ramsay T,
Turgeon AF, English SW. Blood Pressure Management in Early
Aneurysmal Subarachnoid Hemorrhage: A National Cross-Sectional Survey of
Canadian Intensivists and Cerebrovascular Neurosurgeons.
Neurocrit Care. 2024 Jun 11. doi: 10.1007/s12028-024-02011-4. Online
ahead of print.
Hum C, Tahir U, Mei SHJ, Champagne J, Fergusson DA, Lalu M, Stewart DJ, Walley K, Marshall J, Dos Santos CC, Winston BW, Mendelson AA, Dave C, McIntyre L; Canadian Critical Care Translational Biology Group. Efficacy and Safety of Umbilical Cord -Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis. Stem Cells Transl Med. 2024 Feb 21:szae003. doi: 10.1093/stcltm/szae003. Online ahead of print.
Diseases, conditions and populations of interest
Research and clinical approaches
