Sabourin Lab

Luc Sabourin profile picture

Contact Information

Luc Sabourin, PhD
79963
lsabourin@ohri.ca

Ottawa Hospital Research Institute
Centre for Cancer Therapeutics
Cancer Centre Building
501 Smyth Road
Box 926
Ottawa, ON. K1H 8L6

What We Do

We are investigating the regulation of SLK downstream of migration signaling and characterizing SLK downstream signaling systems. Various approaches such as proteomics, gene knock-outs and transgenics, molecular biology and biochemistry are used to understand SLK signaling.

Selected Publications

P. O'Reilly, D. J. Franks, R. Braun and L.A. Sabourin (2005). The Ste20-like kinase SLK is required for cell cycle progression through G2/M. J Biol Chem. 280(51):42383-90.

Z. Chaar, P. O'Reilly, K. Hume and L.A. Sabourin (2006). v-src-Dependent Downregulation of the Ste20-like Kinase SLK by Casein KinaseII. J Biol Chem, 281(38):28193-28199.

S. Wagner, Z.Y. Chaar, K. Roovers, C. J. Storbeck, P. Kolodziej, M. McKay and L.A. Sabourin (2007). FAK/c-src family-dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration. PLoS ONE, 3(4): e1868.

K. Roovers, S. Wagner, M. McKay, P. O'Reilly, V. Lo, J. Northey, J. Chmielecki, W.J. Muller, P. Siegel and L. Sabourin (2009). The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. Oncogene, 28(31):2839-48.

C. Storbeck, K. Hume, S. Wagner, M. McKay, R. Parks, H. Westphal and L.A. Sabourin (2009). The Ldb1 and Ldb2 transcriptional co-factors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell, 2009 Oct;20(19):4174-82.

Meet the Sabourin Lab