Cognitive Health in Multiple Sclerosis Research Lab

Lisa Walker profile picture

Contact Information

Lisa Walker, PhD, C.Psych
613-737-8894
lwalker@ottawahospital.on.ca

Fax -613-737-8895



ORCID logo https://orcid.org/0000-0001-5865-7257

Publications

Selected Publications

Walker, L.A.S., Lindsay-Brown, A.P. & Berard, J.A. (2019). Cognitive fatigability interventions in neurological conditions: A systematic review. Neurology and Therapy, 8(2), 251-271. (published on-line 4 October 2019). http://link.springer.com/article/10.1007/s40120-019-00158-3. PMID: 31586303

Walker, L.A.S., Gardner, C., Freedman, M.S., MacLean, H., Rush, C. & Bowman, M. (2019). Research-to-practice gaps in multiple sclerosis care in one Canadian centre for those with subjective cognitive, mental health and psychosocial concerns. International Journal of MS Care, 21, 243-248. (published on-line Dec. 4, 2018). https://doi.org/10.7224/1537-2073.2017-090. PMID: 31889928

Walker, L.A.S., Marino, D., Berard, J.A., Feinstein, A., Morrow, S.A., Cousineau, D. (2017). Canadian normative data for Minimal Assessment of Cognitive Function in Multiple Sclerosis. Canadian Journal of Neurological Sciences, 44, 547-555 (first published on-line Jul 7, 2017). https://doi.org/10.1017/cjn.2017.199 PMID: 28683843 (Corrigendum – Canadian Journal of Neurological Sciences, 45(5), 604. https://doi.org/10.1017/cjn.2018.308)

Berard, J.A., Fang, Z., Walker, L.A.S., Lindsay-Brown, A., Osman, L., Cameron, I., Cruce, R., Cron, G.O., Freedman, M.S. & Smith, A.M. (2019). Imaging cognitive fatigue in multiple sclerosis: Objective quantification of cerebral blood flow during a task of sustained attention using ASL perfusion fMRI. Brain Imaging and Behavior. (published on-line 29 August 2019). doi: 10.1007/s11682-019-00192-7. PMID: 31468375.

Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S. (2016; 6-12 Aug). Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6 PMID: 27291994

All Other Publications

1. Ramani, S., Berard, J.A. & Walker, L.A.S. (2020). The relationship between neurofilament light chains and cognition in neurological disorders: A scoping review. Journal of the Neurological Sciences. (published on-line 24 November 2020). https://doi: 10.1016/j.jns.2020.117229

2. Berard, J.A. & Walker, L.A.S. (accepted). Increasing the clinical utility of the Paced Auditory Serial Addition Test: Normative data for standard performance, dyad and cognitive fatigability scoring. Cognitive and Behavioral Neurology.

3. Thebault, S., Lee, H., Bose, G., Tessier, D., Abdoli, M., Bowman, M., Berard, J.A. Walker, L.A.S., Rush, C., MacLean, H., Booth, R. Narayanan, S., Arnold, D., Tabard-Cossa, V., Atkins, H., Bar-Or, A. & Freedman, M.S. (2020). Neurotoxicity after haematopoietic stem cell transplant for multiple sclerosis. Annals of Clinical and Translational Neurology. (published on-line 18 April 2020). https://doi: 10.1002/acn3.51045

4. Berard, J.A., Fang, Z., Walker, L.A.S., Lindsay-Brown, A., Osman, L., Cameron, I., Cruce, R., Cron, G.O., Freedman, M.S. & Smith, A.M. (2020). Imaging cognitive fatigue in multiple sclerosis: Objective quantification of cerebral blood flow during a task of sustained attention using ASL perfusion fMRI. Brain Imaging and Behavior, 14, 2417–2428 (published on-line 29 August 2019). doi: 10.1007/s11682-019-00192-7. PMID: 31468375.

5. Walker, L.A.S., Lindsay-Brown, A.P. & Berard, J.A. (2019). Cognitive fatigability interventions in neurological conditions: A systematic review. Neurology and Therapy, 8(2), 251-271. (published on-line 4 October 2019). http://link.springer.com/article/10.1007/s40120-019-00158-3. PMID: 31586303

6. Berard, J.A., Smith, A.M. & Walker, L.A.S. (2019). Predictive models of cognitive fatigue in multiple sclerosis. Archives of Clinical Neuropsychology, 34 (1), 31-38. (published on-line 17 February 2018). https://doi.org/10.1093/arclin/acy014. PMID: 29471423

7. Walker, L.A.S., Gardner, C., Freedman, M.S., MacLean, H., Rush, C. & Bowman, M. (2019). Research-to-practice gaps in multiple sclerosis care in one Canadian centre for those with subjective cognitive, mental health and psychosocial concerns. International Journal of MS Care, 21, 243-248. (published on-line Dec. 4, 2018). https://doi.org/10.7224/1537-2073.2017-090. PMID: 31889928

8. Darlington, P.J., Stopnicki, B., Touil, T., Doucet, J-S., Fawaz, L., Roberts, M.E., Boivin, M-N., Arbour, N., Freedman, M.S., Atkins, H.L., Bar-Or, A. for the Canadian MS/BMT Study Group (L.Walker - member of study group) (2018). Natural killer cells regulate Th17 cells after autologous hematopoietic stem cell transplantation for relapsing remitting multiple sclerosis. Frontiers in Immunology, 9, article 834. (published on-line 07 May 2018). Doi: 10.3389/fimmu.2018.00834. PMID: 29867923

9. Barbu, R.M., Berard, J.A., Gresham, L.M. & Walker, L.A.S. (2018). Longitudinal stability of cognition in early phase relapsing-remitting multiple sclerosis: Does cognitive reserve play a role? International Journal of MS Care, 20(4): 173-179 (published on-line Sept 11, 2017). https://doi.org/10.7224/1537-2073.2016-073. PMID: 30150901

10. Mioduszewski. O., MacLean, H., Poulin, P.A., Smith, A.M. & Walker, L.A.S. (2018). Trait mindfulness and wellness in multiple sclerosis. Canadian Journal of Neurological Sciences, 45(5), 580-582. (published on-line 12 July 2018). https://doi.org/10.1017/cjn.2018.51. PMID: 30234464

11. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2018). Revisiting cognitive reserve and cognition in multiple sclerosis: a closer look at the role of depression. Multiple Sclerosis Journal, 24(2), 186-195 (published on-line 13 February 2017). http://journals.sagepub.com/doi/pdf/10.1177/1352458517692887 PMID: 28273771

12. Berard, J.A., Smith, A.M. & Walker, L.A.S. (2018). A longitudinal evaluation of cognitive fatigue in multiple sclerosis using the Paced Auditory Serial Addition Test (PASAT). International Journal of MS Care, 20, 55-61 (first published on-line Jul 13, 2017). https://doi.org/10.7224/1537-2073.2016-106. PMID: 29670491

13. Walker, L.A.S., Marino, D., Berard, J.A., Feinstein, A., Morrow, S.A., Cousineau, D. (2017). Canadian normative data for Minimal Assessment of Cognitive Function in Multiple Sclerosis. Canadian Journal of Neurological Sciences, 44, 547-555 (first published on-line Jul 7, 2017). https://doi.org/10.1017/cjn.2017.199 PMID: 28683843 (Corrigendum – Canadian Journal of Neurological Sciences, 45(5), 604. https://doi.org/10.1017/cjn.2018.308)

14. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2017). Deconstructing the Symbol Digit Modalities Test in multiple sclerosis: The role of memory. Multiple Sclerosis and Related Disorders, 17, 184-189. http://dx.doi.org/10.1016/j.msard.2017.08.006. PMID: 29055455

15. Walker, L.A.S., Bourque, P., Smith, A.M. & Warman Chardon, J. (2017). Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration. Neuropsychology, 31(3), 292-303 (first published on-line Nov 21, 2016). http://dx.doi.org/10.1037/neu0000322. PMID: 27869457

16. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2017). Processing speed and distractibility in multiple sclerosis: the role of sleep. Multiple Sclerosis and Related Disorders, 11, 40-42. http://dx.doi.org/10.1016/j.msard.2016.11.012 PMID: 28104254

17. Stamenova, V., Jennings, J.M., Cook, S.P., Gao, F. Walker, L.A.S., Smith, A.M., Davidson, P.S.R. (2017). Repetition-Lag Memory Training is Feasible in Patients with Chronic Stroke Patients, Including Those with Memory Problems. Brain Injury, 31(1), 57-67. (on-line 23 November 2016). http://www.tandfonline.com/doi/full/10.1080/02699052.2016.1222081 PMID: 27880059

18. Patel, V.P., Zambrana, A., Walker, L.A.S., Herrmann, H. & Feinstein, A. (2017). Distraction adds to the cognitive burden in multiple sclerosis. Multiple Sclerosis Journal, 23(1), 106-113. (online 24 March 2016) DOI: 10.1177/1352458516641208 PMID: 27012660

19. Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S. (2016; 6-12 Aug). Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6 PMID: 27291994
20. Walker, L.A.S., Berard, J.A., Bowman, M., Atkins, H.L., Lee, H., Arnold, D. & Freedman, M.S. (2016). Longitudinal change in PASAT performance following immunoablative therapy and haematopoietic stem cell transplant in multiple sclerosis. Multiple Sclerosis and Demyelinating Disorders, 1:12, DOI:10.1186/s40893-016-0014-y
21. Patel, V.P., Zambrana, A., Walker, L.A.S., Herrmann, N., Swartz, R. & Feinstein, A. (2016). Distractibility in multiple sclerosis: the role of depression. Multiple Sclerosis Journal: Experimental, Translational and Clinical, 2, 1-5. DOI: 10.1177/2055217316653150 PMID: 28607730

22. Walker, L.A.S., Osman, L., Berard, J.A., Rees, L.M, Freedman, M.S., MacLean, H. & Cousineau, D. (2016). Brief International Cognitive Assessment for MS (BICAMS): Canadian contribution to the international validation project. Journal of the Neurological Sciences, 362, 147-152. doi:10.1016/j.jns.2016.01.040 PMID: 26944137

23. Stamenova, V., Jennings, J.M., Cook, S.P., Walker, L.A.S., Smith, A.M. & Davidson, P.S.R. (2014). Training Recollection in Healthy Older Adults: Clear Improvements on the Training Task, but Little Evidence of Transfer. Frontiers in Psychology, 8, 1-13. doi: 10.3389/fnhum.2014.00898 PMID: 25477801 (Corrigendum doi:10.3389/fnhum.2015.00658 PMID: 26648862)

24. Berard, J.A., Walker, L.A.S., Smith, A.M. & Freedman, M.S. (2014). Longitudinal comparison of desktop and fMRI scanner versions of the Computerized Test of Information Processing in Multiple Sclerosis: A pilot study. Journal of Multiple Sclerosis, 2(2). http://dx.doi.org/10.4172/jmso.1000121

25. Berrigan, L.I., Fisk, J.D., Walker, L.A.S., Wojtowicz, M., Rees, L.M., Freedman, M.S. & Marrie, R-A. (2014). Reliability of Regression-Based Normative Data for the Oral Symbol Digit Modalities Test: An Evaluation of Demographic Influences, Construct Validity, and Impairment Classification Rates in Multiple Sclerosis Samples. The Clinical Neuropsychologist, 28(2), 281-99. http://dx.doi.org/10.1080/13854046.2013.871337 PMID: 24438521

26. Berard, J.A., Bowman, M., Atkins, H.L., Freedman, M.S. & Walker, L.A.S. (2014). Cognitive fatigue in individuals with multiple sclerosis undergoing immunoablative therapy and haematopoietic stem cell transplantation. Journal of the Neurological Sciences, 336, 132-137. http://dx.doi.org/10.1016/j.jns.2013.10.023 PMID: 24189209

27. Walker, L.A.S., Berard, J.A., Atkins, H.L., Bowman, M., Lee, H. & Freedman, M.S. (2014). Cognitive change and neuroimaging following immunoablative therapy and hematopoietic stem cell transplantation in multiple sclerosis: A pilot study. Multiple Sclerosis and Related Disorders, 3, 129-135. http://dx.doi.org/10.1016/j.msard.2013.05.001 PMID: 25877984

28. Berrigan, L.I., LeFevre, J., Rees, L.M., Walker, L.A.S., Berard, J. & Freedman, M.S. (2013). Cognition in early relapsing-remitting multiple sclerosis: Consequences may be relative to working memory. Journal of the International Neuropsychological Society, 19(8), 938-949. http://dx.doi.org/10.1017/S1355617713000696 PMID: 23866100

29. Walker, L.A.S., Berard, J., Berrigan, L.I., Rees, L.M. & Freedman, M.S. (2012). Detecting cognitive fatigue in multiple sclerosis: Method matters. Journal of the Neurological Sciences, 316, 86-92. doi:10.1016/j.jns.2012.01.021. PMID: 22336698

30. Walker, L.A.S., Cheng, A., Berard, J., Berrigan, L.I., Rees, L.M. & Freedman, M.S. (2012). Tests of information processing speed: What do people with multiple sclerosis think about them? International Journal of MS Care, 14, 92-99. (article won Herndon Award for Outstanding International Journal of MS Care Article for best article published in 2012) doi: 10.7224/1537-2073-14.2.92. PMID: 24453739

31. Smith, A.M., Walker, L.A.S., Freedman, M.S., Berrigan, L.I., St. Pierre, J., Hogan, M. & Cameron, I. (2012). Activation Patterns in Multiple Sclerosis on the Computerized Tests of Information Processing: Speed and Task Matter. Journal of the Neurological Sciences, 312, 131-137. doi: 10.1016/j.jns.2011.08.003 PMID: 21862036

32. Walker, L.A.S., Mendella, P.D., Stewart, A., Freedman, M.S. & Smith, A.M (2011). Meaningful change in cognition in MS: Method matters. Canadian Journal of Neurological Sciences, 38, 282-288. DOI: 10.1017/s0317167100011471 PMID: 21320834

33. Tombaugh, T. N., Berrigan, L. I., Walker, L.A.S. & Freedman, M. S. (2010). The Computerized Tests of Information Processing (CTIP) Offers an Alternative to the PASAT for Assessing Cognitive Processing Speed in Individuals with Multiple Sclerosis. Cognitive and Behavioral Neurology, 23(3), 192-198. DOI: 10.1097/WNN.0b013e3181cc8bd4 PMID: 20829669

34. Smith, A.M., Walker, L.A.S., Freedman, M.S., DeMeulemeester, C., & Hogan, M. (2009). fMRI investigation of disinhibition in cognitively impaired patients with multiple sclerosis. Journal of the Neurological Sciences, 281, 58-63. Published on-line (doi:10.1016/j.jns.2009.02.366). PMID: 19344919

35. Walker, L. & DeMeulemeester, C. (2008). Spontaneous intracranial hypotension masquerading as frontotemporal dementia. The Clinical Neuropsychologist, 22, 1035-1053. doi: 10.1080/13854040701874386 PMID: 18609334

36. Reicker, L. I., Tombaugh, T. N., Walker, L., Freedman, M. S. (2007). Reaction Time: An alternative method for assessing the effects of multiple sclerosis on information processing speed. Archives of Clinical Neuropsychology, 22, 655-664. https://doi.org/10.1016/j.acn.2007.04.008 PMID: 17532182

PubMed Listings

For more publications use this PubMed ID link.