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Contact Information

Pierre Mattar, PhD


Pierre Mattar

Scientist, Regenerative Medicine Program
Ottawa Hospital Research Institute
Assistant Professor, Cellular and Molecular Medicine
University of Ottawa

Research Interests

The lab is focused on how retinal cell types are i) produced and ii) maintained.  

Retinal cell death plays a role in all of the main causes of blindness. Once killed, retinal neurons are lost forever. These cells cannot be regenerated in humans.

Deciphering how retinal neurons are produced during development might help us to regenerate retinal tissue artificially. Cells could be generated in the lab, and then transplanted into individuals to replace the cells that they have lost.  

Understanding the degenerative process might provide new approaches that could help prevent or mitigate degeneration.   

Brief Biography

Selected Publications

1. Mattar P, Ericson J, Blackshaw S, Cayouette M. A Conserved Regulatory Logic Controls Temporal Identity in Mouse Neural Progenitors. Neuron. 2015 Feb. 4; 85(3): 497-504. http://www.ncbi.nlm.nih.gov/pubmed/25654255 2. Li S†, Mattar P†, Dixit R†, Lawn SO, Wilkinson G, Kinch C, Eisenstat D, Kurrasch DM, Chan JA, Schuurmans C.  RAS/ERK Signaling Controls Proneural Genetic Programs in Cortical Development and Gliomagenesis.  J Neurosci. 2014 Feb 5; 34(6):2169-90. http://www.ncbi.nlm.nih.gov/pubmed/24501358 3. Li S†, Mattar P†, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Dixit R, Kurrasch DM, Ma YC, Chan JA, Wallace V, Dilworth FJ, Brand M, Schuurmans C. GSK3 Temporally Regulates Neurogenin 2 Proneural Activity in the Neocortex. J Neurosci. 201 Jun 6;32(23):7791-805. http://www.ncbi.nlm.nih.gov/pubmed/22674256 4. Mattar P, Langevin LM, Markham K, Klenin N, Shivji S, Zinyk D, Schuurmans C. bHLH transcription factors cooperate to specify a cortical projection neuron identity.  Mol Cell Biol. 2008 Mar;28(5):1456-69. http://www.ncbi.nlm.nih.gov/pubmed/18160702 5. Mattar P†, Cayouette M†. Mechanisms of temporal identity regulation in mouse retinal progenitor cells. Neurogenesis. 2015 Dec. 2:1, e1125409. http://www.tandfonline.com/doi/full/10.1080/23262133.2015.1125409

†Denotes equal authorship

Diseases, conditions and populations of interest

Glaucoma; Macular degeneration; Retinal disease; Vision

Research and clinical approaches

Basic research; Bioinformatics; Cell therapy; Epigenetics; Gene expression; Genetics; Genomics; Model organisms; Molecular and cellular biology; Proteomics; Regenerative medicine; Stem cells; Transgenic/knockout models