Senior Scientist, Neuroscience Program
Ottawa Hospital Research Institute
Professor, Department of Psychiatry and Cellular and Molecular Medicine
University of Ottawa
Scientist, University of Ottawa Brain and Mind Research Institute
Clinical Investigator, Memory Clinic
Dr. Bergeron began his career as principal investigator in basic science (Neuroscience) at the Ottawa Hospital Research Institute in 2002. His laboratory is committed to unraveling the understanding of the role of glutamate in the nervous system, and how this amino acid could play a role in the pathophysiology of some neuropsychiatric disorders. Dr. Bergeron’s research focus is dedicated in investigating the role of glycine and sigma receptor and how they modulate a subtype of glutamate receptor: NMDA receptor. The NMDA receptor is known to be involved in synaptic transmission and plasticity and has been proposed to play a role in the etiology of dementia, schizophrenia, stroke and other neuropsychiatric disorders.
Diseases that are investigated in Dr. Bergeron’s laboratory:
Alzheimer disease and ischemic stroke.
The laboratory of Dr Bergeron is using a number of research techniques such as: whole-cell patch-clamp technique, sniffer-patch technique; confocal microscopy, 2-Photons, calcium imaging; biochemistry: immunublotting, immunohistochemistry, co-precipitation; molecular biology: mutagenesis, RTPCR, cloning, cell culture; behavior.
Transgenic Mice that are studied in Dr. Bergeron’s lab:
Glycine transporter type 1 knockdown (GlyT1+/-), Serine Racemase knockout (SR-/-), Sigma Receptor type 1 knockout (Sig1R-/-), Sigma Receptor type 1 overexpression, 3 x Tg-AD harboring PS1M146V, APPSwe, and tauP301L transgenes.
Dr. Bergeron is a physician, a psychiatrist and a neuroscientist. He obtained his medical degree (M.D.) from the University of Sherbrooke, Quebec (1986) and certification in the specialty of Psychiatry (FRCPC) from the University of Ottawa, Ontario (1990). He completed a doctoral degree (Ph.D.) in Neuroscience at McGill University, Montreal, Quebec (1996) and trained as a postdoctoral fellow in Neuroscience for 5 years at Harvard University, Boston, M.A., USA (2002).