Shirley Mei profile picture

Contact Information

Shirley Mei, PhD, MSc
6137985555, ext. 73278
smei@ohri.ca

Investigator
Regenerative Medicine

Ottawa Hospital Research Institute
501 Smyth Road
Ottawa, ON K1H 8L6
Canada

Shirley Mei

Investigator, Regenerative Medicine Program
Ottawa Hospital Research Institute

Research Interests

  • Translational research: applying scientific discoveries to clinical trials
  • Stem cell and cell-based gene therapy
  • Mesenchymal stem cells
  • Cellular therapeutics product and potency assay development
  • Sepsis/septic shock
  • Acute lung injury/Acute respiratory distress syndrome (ARDS)
  • Critical care
  • Vascular

Brief Biography


Dr. Shirley Mei has a keen interest in translational research to bring basic/preclinical research to clinical testing. Her research interest focuses on the development of stem/progenitor cell and cell-based gene therapy strategies for sepsis/septic shock, acute lung injury and pulmonary arterial hypertension. Dr. Mei received her MSc from the Department of Biochemistry & Biomedical Sciences at McMaster University, and PhD from the Institute of Medical Science at the University of Toronto.

Selected Publications


Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ.  Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.  Critical Care Medicine.  2019.  Forthcoming – manuscript accepted.      

McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA; Canadian Critical Care Trials Group.; Canadian Critical Care Translational Biology Group. Cellular Immunotherapy for Septic Shock. A Phase I Clinical Trial. Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347. doi: 10.1164/rccm.201705-1006OC. PubMed PMID: 28960096.      

Schlosser K, Taha M, Deng Y, McIntyre LA, Mei SHJ, Stewart DJ. High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice. Thorax. 2018 Mar;73(3):248-261. doi: 10.1136/thoraxjnl-2017-210413. Epub 2017 Sep 25. PubMed PMID: 28947667; PubMed Central PMCID: PMC5870448.      

Mei SH, Dos Santos CC, Stewart DJ. Advances in Stem Cell and Cell-Based Gene Therapy Approaches for Experimental Acute Lung Injury: A Review of Preclinical Studies. Hum Gene Ther. 2016 Oct;27(10):802-812. Review. PubMed PMID: 27531647.      

Mei SH, Haitsma JJ, Dos Santos CC, Deng Y, Lai PF, Slutsky AS, Liles WC, Stewart DJ. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med. 2010 Oct 15;182(8):1047-57. doi: 10.1164/rccm.201001-0010OC. Epub 2010 Jun 17. PubMed PMID: 20558630.      

Mei SH, McCarter SD, Deng Y, Parker CH, Liles WC, Stewart DJ. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med. 2007 Sep;4(9):e269. PubMed PMID: 17803352; PubMed Central PMCID: PMC1961632.    

Research and clinical approaches


Basic research; Biomarkers; Cell therapy; Critical care; Disease models; Epigenetics; Epigenetics; Gene therapy; Knowledge translation and implementation research; Molecular and cellular biology; Regenerative medicine; Stem cells