Alexander Sorisky
Senior Scientist Emeritus, Inflammation and Chronic Disease
Ottawa Hospital Research Institute
Active Attending Medical Staff, Division of Endocrinology and Metabolism
The Ottawa Hospital
Professor, Department of Medicine and Department of Biochemistry, Microbiology and Immunology
University of Ottawa
Research Interests
Obesity, type 2 diabetes, and cardiovascular disease risk
Adipose progenitor cell fate
Adipocyte biology
Insulin signal transduction
Thyroid stimulating hormone (TSH) signal transduction
Brief Biography
Dr. Alexander Sorisky received his medical degree from McGill University and completed the postgraduate program in Medical Biochemistry and Internal Medicine at McGill University and University of Ottawa. He undertook Endocrinology & Metabolism training at the University of Vermont, and continued there as a research fellow supported by MRC (now CIHR), in the Departments of Biochemistry and of Pathology and Molecular Genetics. He returned to Canada, and established his clinical activities and research program in Ottawa.
He is Professor of Medicine and of Biochemistry, Microbiology & Immunology, and a member of the Division of Endocrinology and Metabolism, University of Ottawa. He is Senior Scientist Emeritus in the Inflammation and Chronic Disease Program of the Ottawa Hospital Research Institute at The Ottawa Hospital. His awards include a Medical Research Council of Canada Scholar, a Heart and Stroke Foundation of Ontario Career Investigator, and a Premier's Research Excellence Award of Ontario.
Dr. Sorisky's research interest is cell-surface receptor signal transduction in the context of adipose cell responses, such as differentiation, proliferation, survival, and adipokine production. He aims to understand how disturbances in adipose cell signal transduction networks, regulated by cell-surface tyrosine kinase or G protein-coupled receptors, result in cariometabolic malfunction such as insulin resistance and inflammation.
Selected Publications
Gagnon A, Antunes TT, Ly T, Pongsuwan P, Gavin C, Lochnan HA, Sorisky A. TSH-stimulates lipolysis in adipocytes in culture and raises serum free fatty acid levels in vivo. Metabolism 59:547-553, 2010.
Molgat ASD, Gagnon A, Sorisky A. Macrophage-induced preadipocyte survival depends on signaling through Akt, ERK1/2, and reactive oxygen species. Exp Cell Res 317:521-530, 2011.
Sorisky A, Molgat ASD, Gagnon A. Macrophage-induced adipose tissue dysfunction and the preadipocyte: should I stay (and differentiate) or should I go? Adv Nutr 4:67-75, 2013.
Gagnon A, Foster C, Landry A, Sorisky A. The role of interleukin-1β in the anti-adipogenic action of macrophages on human preadipocytes. J Endocrinol 217:197-206, 2013.
Gagnon A, Langille ML, Chaker S, Antunes TT, Durand J, Sorisky A. TSH signaling pathways that regulate MCP-1 in human differentiated adipocytes. Metabolism 63:812-821, 2014.
Note: This is not a complete list of publications. More publications are available via the Pubmed link under the tab "Publications"Diseases, conditions and populations of interest
Research and clinical approaches
