Senior Scientist, Chronic Disease Program
Ottawa Hospital Research Institute

HIV immunopathogenesis
Immune based therapies for HIV Infection

http://www.cancurehiv.org/

Dr. Angel graduated from medical school at the University of Toronto in 1988, which was followed by an internal medicine residency in Toronto. After one year as the chief medical resident at St. Paul&rsquos Hospital in Vancouver, he did his clinical and research infectious diseases training at the New England Medical Center/Tufts University in Boston. In 1995, Dr. Angel joined the Division of Infectious Diseases, Department of Medicine at the Ottawa General Hospital. Since that time he has been involved in laboratory based and clinical research as well as teaching and patient care. His research is focused on understanding how HIV damages the immune system and how these insights can potentially lead to new therapies. Dr. Angel is currently a Professor of Medicine at the University of Ottawa, a Senior Scientist in the Ottawa Hospital Research Institute and Head of the Division of Infectious Diseases.

- A.M. Crawley, S. Faucher, J.B. Angel. “Soluble IL-7 Rα (CD127) inhibits IL-7 activity and is increased in HIV infection.” J Immunol 184:4679-4687, 2010.

- J.B. Angel, J.-P. Routy, C. Tremblay, D. Ayers, R. Woods, J. Singer, N. Bernard, C. Kovacs, F. Smaill, S. Gurunathan, R.-P. Sekaly. “A Randomized Controlled Trial of HIV Therapeutic Vaccination Using ALVAC With or Without Remune” AIDS 25:731-739, 2011.

- C.T. Costiniuk, D.A. Fergusson, S. Doucette, J.B. Angel. “Discontinuation of Pneumocystis jirovecii Pneumonia prophylaxis with CD4+ <200 cells/µL and virologic suppression: A systematic review.” PLoS One 6(12): e28570, 2011.

- A. Crawley, J.B. Angel. “The influence of HIV on CD127 expression and its potential implications of IL-7 therapy.” Seminars in Immunology 24(3): 231-240, 2012.

- C.T. Costiniuk, C. Kovacs, J.P. Routy, J. Singer, S. Gurunathan, R.P. Sekaly, J.B.Angel. “Human immunodeficiency virus rebound in blood and seminal plasma following discontinuation of antiretroviral therapy.” AIDS Res Hum Retroviruses 29(2): 266-269, 2013.

HIV; Infectious disease

Basic research; Clinical research; Translational research