Jonathan B. Angel, MD

jangel@ottawahospital.on.ca

Senior Scientist, Chronic Disease, Ottawa Hospital Research Institute

Infectious Disease Specialist

Associate Professor, Faculty of Medicine, University of Ottawa

Biographical Sketch

Dr. Angel graduated from medical school at the University of Toronto in 1988 which was followed by an internal medicine residency in Toronto. After one year as the chief medical resident at St. Paul's Hospital in Vancouver, he did his clinical and research infectious diseases training at the New England Medical Centre/Tufts University in Boston supported by an MRC fellowship. In 1995, Dr. Angel joined the Division of Infectious Diseases, Department of Medicine at the Ottawa General Hospital. Since that time he has been involved in basic science and clinical research as well as patient care. His research is focused in three main areas 1) basic science: mechanisms of HIV-induced cellular immune dysfunction, 2) translational research: the impact of antiretroviral and immune-based therapies on immune function in patients with HIV infection, and 3) clinical trials: studies of immune-based therapies including HIV vaccines, in patients with HIV infection. Dr. Angel is currently an Associate Professor of Medicine at the University of Ottawa and a Clinician Scientist in the Ottawa Hospital Research Institute. He is supported by a Scientist Salary Award from the AIDS Program Committee, Ontario Ministry of Health and has research funding from CIHR and the Ontario HIV Treatment Network (OHTN).

Research Interests:

HIV immunopathogenesis
Immune based therapies for HIV Infection

Major Research Activities:

1) Studies on the mechanisms of HIV induced immune dysfunction
2) Studies on immune restoration with effective anti-HIV therapy
3) Studies on immune based therapies and vaccines in HIV infection

Major Awards/Affiliations:

Scientist Salary Award, AIDS Program, Ontario Ministry of Health, 1999-2004

Canadian Foundation for Innovation, New Opportunities Investigator 1999

Canadian Association for HIV Research, Council Member, 1999-2001

CANVAC Member 2001

Most Recent Publications (provided by The Ottawa Hospital Library Database)

Costiniuk CT;McCarthy AE;Talreja H;Zimmerman D;Liu TT;Owen E;Angel JB;, (2011 Mar), Acute renal failure and disseminated intravascular coagulation associated with rifampin in tuberculosis treatment, Int J Tuberc Lung Dis, Vol.15, Issue 3, 421

Hibbert B;Costiniuk C;Hibbert R;Joseph P;Alanazi H;Simard T;Dennie C;Angel JB;O'Brien ER;, (2010 Oct), Cardiovascular complications of Salmonella enteritidis infection, Can J Cardiol , Vol.26, Issue 8, 323-325 -> view abstract

Balfour L;Corace K;Tasca GA;Tremblay C;Routy JP;Angel JB;, (2010 Nov), Altruism motivates participation in a therapeutic HIV vaccine trial (CTN 173), AIDS Care , Vol.22, Issue 11, 1403-1409 -> view abstract

Crawley AM;Faucher S;Angel JB;, (2010 May 1), Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection, J Immunol , Vol.184, Issue 9, 4679-4687 -> view abstract

Lalonde RG;Thomas R;Rachlis A;Gill MJ;Roger M;Angel JB;Smith G;Higgins N;Trottier B;, (2010 Jan), Successful implementation of a national HLA-B*5701 genetic testing service in Canada, Tissue Antigens, Vol.75, Issue 1, 12-18 -> view abstract

Leece P;Kendall C;Touchie C;Pottie K;Angel JB;Jaffey J;, (2010 Dec), Cervical cancer screening among HIV-positive women. Retrospective cohort study from a tertiary care HIV clinic, Can Fam Physician, Vol.56, Issue 12, e425-e431

O'Connor AM;Crawley AM;Angel JB;, (2010 Dec), Interleukin-7 enhances memory CD8(+) T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection, Immunology, Vol.131, Issue 4, 525-536 -> view abstract

Angel JB;Greaves W;Long J;Ward D;Rodriguez AE;Scevola D;DeJesus E;, (2009 Nov 27), Virologic and immunologic activity of PegIntron in HIV disease, AIDS , Vol.23, Issue 18, 2431-2438 -> view abstract

Ma W;Mishra S;Gajanayaka N;Angel JB;Kumar A;, (2009 Mar 20), HIV-1 Nef inhibits lipopolysaccharide-induced IL-12p40 expression by inhibiting JNK-activated NFkappaB in human monocytic cells, Journal of Biological Chemistry, Vol.284, Issue 12, 7578-7587 -> view abstract

Faucher S;Crawley AM;Decker W;Sherring A;Bogdanovic D;Ding T;Bergeron M;Angel JB;Sandstrom P;, (2009), Development of a quantitative bead capture assay for soluble IL-7 receptor alpha in human plasma, PLoS ONE [Electronic Resource], Vol.4, Issue 8, e6690 -> view abstract

Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).