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 Associate Scientist, Neuroscience, Ottawa Hospital Research Institute
Surgeon, Division of Urology, Department of Surgery, The Ottawa Hospital
Assistant Professor and Director of Basic Urological Research, Division of Urology, Department of Surgery, Faculty of Medicine, University of Ottawa
Research
The ultimate goal of Dr. Bella's research is to develop novel approaches to prevent or repair the nerve damage that can occur during treatments for prostate cancer. His laboratory focuses on the neurobiology of cavernous nerve response to injury, with emphasis on molecular mechanisms involved in neuroprotection and neuroregeneration. His research also has implications for the repair and regeneration of other types of nerves.
Prior to Dr. Bella's recruitment to the Ottawa Hospital Research Institute, he trained at the University of Western Ontario (Lawson Research Institute under Dr. Gerald B Brock) and as a post-doctoral fellow under Dr. Tom F Lue at the University of California San Francisco where he made significant strides delineating the molecular mechanisms of cavernous nerve regeneration and applied this knowledge to pursue new strategies for peripheral nerve neuromodulation after injury. Dr. Bella's research is comprised of four main streams: neurotrophins, identification and evaluation of novel neuromodulators, use of novel strategies to promote nerve protection and/or regeneration, and the use of adipose-derived stem cells to optimize injury response.
Recent Publications
Bella AJ, Lin GT, Cagiannos I, Lue TF. Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury. Asian J Androl 10 (1); 54-60, 2008
Hayashi N, Bella AJ, Wang G, Deng D, Nunes L, Lue TF. The effect of estrogen on the mechanism of urinary incontinence in a rat model of stress urinary incontinence. CUAJ 1(3): 256-263, 2007
Bella AJ, DeYoung L, al-Numi M, Brock GB. Daily administration of phosphodiesterase-5 inhibitors for urologic and non-urologic indications. Eur Urol 52(4): 990-1005, 2007
Bella AJ, Lue TF. Words of wisdom. Re: Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. Eur Urol 52(3): 918-919, 2007
Bella AJ, Perelman MA, Brant WO, Lue TF. Peyronie's disease. J Sex Med 4: 1527-1538, 2007
Brant WO, Brock GB, Lue TF, Gerridzen RG, Bella AJ. Salvage strategies for nonresponders to phosphodiesterase-5 inhibitor treatment for erectile dysfunction in the aging male. Aging Health 3(4): 527-542, 2007
Domes T, De Young L, Gan BS, Bella AJ, Brock GB. The role of proteomics in Peyronie's disease. J Sex Med 4(4 Pt 1): 867-877, 2007
Bella AJ, Lin G, Garcia MM, Tantiwonge T, Lin CS, Brant WO, Lue TF. Upregulation of penile brain-derived neurotrophic factor (BDNF) and activation of the JAK/STAT signaling pathway in the major pelvic ganglion of the rat following cavernous nerve transection European Urology 52(2): 574-581, 2007
Brant WO, Bella AJ, Lue TF. Treatment options for erectile dysfunction. Endo Metabol Clin NA 36(2): 465-479, 2007
Bella AJ, Fandel TM, Tantiwongse K, Brant WO, Klein R, Garcia CA, Lue TF. Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat J Brachial Plex Peripher Nerve Inj 2:5, 2007
Bella AJ, Hayashi N, Carrion R, Price R, Lue TF. FK1706 enhances functional recovery following bilateral cavernous nerve crush injury in a rat model J Sex Med 4: 341-347, 2007
Bella AJ, Lin G, Tantiwongse K, Garcia M, Lin CS, Brant W, Lue TF. Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 1. J Sex Med 3:815-820, 2006
Lin G, Bella AJ, Lue TF, Lin CS. Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 2. J Sex Med 3:821-829, 2006
Fandel T, Bella AJ, Tantiwongse K, Garcia M, Nunes L, Thuroff JW, Tanagho EA, Lue TF. The effect of intracavernous growth differentiation factor-5 in a rat model of cavernous nerve injury. BJU Int 98(3):632-636, 2006
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