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Scientist, Regenerative Medicine Program, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute
Director, Biotherapeutics Core Facilities, Ottawa Hospital Research Institute
Assistant Professor, Department of Medicine, Faculty of Medicine, University of Ottawa
Research Interests
My research interests involve the development of genetically engineered stem and progenitor cells as regenerative therapies for cardiopulmonary diseases. Insights into the pathogenesis of vascular diseases are gained from cellular and molecular studies in relevant animal models and from human tissues. Novel cellular and gene therapies are then developed to correct the key pathological mechanisms. Novel bioactive materials are also investigated to enhance homing, engraftment, and differentiation of relevant stem and progenitor cells.
Most Recent Publications
Karoubi G, Stewart DJ, Courtman DW. A population analysis of VEGF transgene expression and secretion. Biotechnol Bioeng. 2008 Dec 1;101(5):1083-93.
Markway BD, McCarty OJ, Marzec UM, Courtman DW, Hanson SR, Hinds MT.Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody. Tissue Eng Part C Methods. 2008 Jun;14(2):97-105.
Laurent G, Moe GW, Hu X, Pui-Sze So P, Ramadeen A, Leong-Poi H, Doumanovskaia L, Konig A, Trogadis J, Courtman D, Strauss BH, Dorian P. Simultaneous right atrioventricular pacing: a novel model to study atrial remodeling and fibrillation in the setting of heart failure. J Card Fail. 2008 Apr;14(3):254-62.
Foltz WD, Ormiston ML, Stewart DJ, Courtman DW, Dick AJ. MRI characterization of agarose gel micro-droplets at acute time-points within the rabbit lumbar muscle. Biomaterials. 2008 Apr;29(12):1844-52. Epub 2008 Feb 21.
Laurent G, Moe G, Hu X, Leong-Poi H, Connelly KA, So PP, Ramadeen A, Doumanovskaia L, Konig A, Trogadis J, Courtman D, Strauss B, Dorian P.
Experimental studies of atrial fibrillation: a comparison of two pacing models. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1206-15. Epub 2008 Jan 4.
Ray JB, Arab S, Deng Y, Liu P, Penn L, Courtman DW, Ward ME. Oxygen regulation of arterial smooth muscle cell proliferation and survival. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H839-52. Epub 2007 Nov 30.
Laurent G, Moe G, Hu X, Holub B, Leong-Poi H, Trogadis J, Connelly K, Courtman D, Strauss BH, Dorian P. Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model. Cardiovasc Res. 2008 Jan;77(1):89-97. Epub 2007 Sep 20.
Feintuch A, Ruengsakulrach P, Lin A, Zhang J, Zhou YQ, Bishop J, Davidson L, Courtman D, Foster FS, Steinman DA, Henkelman RM, Ethier CR. Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H884-92. Epub 2006 Sep 29.
Zhao YD, Courtman DW, Ng DS, Robb MJ, Deng YP, Trogadis J, Han RN, Stewart DJ. Microvascul Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer. Am J Respir Cell Mol Biol. 2006 Aug;35(2):182-9. Epub 2006 Mar 16.
Dutly AE, Kugathasan L, Trogadis JE, Keshavjee SH, Stewart DJ, Courtman DW. Fluorescent microangiography (FMA): an improved tool to visualize the pulmonary microvasculature. Lab Invest. 2006 Apr;86(4):409-16.
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