Dr. Paul C. Hébert, MD, FRCPC, MHSc (Epid)
Affiliate Investigator, Clinical Epidemiology, Ottawa Hospital Research InstituteProfessor of Medicine, Surgery, Anesthesiology and Epidemiology, University of Ottawa
Intensivist, Department of Critical Care
Researcher, Department of Medicine / Critical Care
Dr. Paul C. Hébert is a Critical Care Physician at The Ottawa Hospital and a Senior Scientist in the Clinical Epidemiology Program at the Ottawa Hospital Research Institute (OHRI). He also holds the rank of Full Professor in the Department of Medicine (Critical Care) at the University of Ottawa, with cross-appointments to the Departments of Anesthesiology and Surgery as well as Epidemiology & Community Medicine. During his 14 years on Faculty at the University of Ottawa, Dr. Hébert established the Clinical Epidemiology Program at the General Campus of The Ottawa Hospital (1998) and the University of Ottawa Centre for Transfusion Research (1999). In his role as Vice-Chair Research from 2003 to 2007 he was responsible for the overall strategic direction of research for the Department of Medicine at the University of Ottawa. Among other awards, Dr. Hébert was honored with the "Researcher of the Year Award" from the OHRI (2001) and also received a "Premier's Research Excellence Award" from the Ontario Ministry of Health and Long-Term Care (2002). On January 2, 2007, Dr. Hébert was appointed Editor-in-Chief of the Canadian Medical Association Journal (CMAJ).
Dr. Hébert's research interests center on the examination of transfusion practice (when and what to transfuse), including the use of alternatives to transfusion, blood conservation, resuscitation fluids, as well as on cardiac resuscitation and trauma research. He led a groundbreaking trial entitled "Transfusion Requirements in Critical Care (TRICC)", which was published in the New England Journal of Medicine (NEJM). This trial showed that patients treated aggressively with transfused blood had a higher rate of death during hospitalization and a greater rate of organ failure than patients whose doctors waited to order a transfusion. This trial has impacted how clinicians approach blood transfusions worldwide and has generated a significant research agenda around the world. Based upon this seminal trial, Dr. Hébert has undertaken more than 30 research projects with a focus on transfusion practice and bleeding control. To date, he has published in excess of 250 articles, obtained a large number of peer-reviewed grants (with a combined value in excess of $30 million) and trained and mentored numerous individuals. He continues to participate on national peer-review panels, including Canadian Institutes of Health Research, NSERC and Canada Foundation for Innovation panels.
Recent Publications (2007-2008)
S. Kanji, R. Stewart, D. Fergusson, L. McIntyre, A. Turgeon, P.C. Hebert. Treatment of New-Onset Atrial Fibrillation in Non-Cardiac ICU Patients: A Systematic Review of Randomized Controlled Trials. Crit Care Med 2008 May;36(5):1620-4.
Clavet H, Hebert PC, Fergusson D, Doucette S, Trudel G. Joint contracture following prolonged stay in the intensive care unit. CMAJ 2008 Mar 11;178(6):691-7
JA Russell, KR Walley, J Singer, AC Gordon, PC Hebert, J Cooper, CL Holmes, S Mehta, JT Granton, MW Storms, DJ Cook, JJ Presneill, D Ayers, for the VASST Investigators. Vasopressin versus norepinephrine infusion in patients with septic shock. NEJM. 2008, Feb;358(9):877-887.
LA McIntyre, D Fergusson, DJ Cook, RC Nair, D Bell, V Dhingra, B Hutton, S Magder, PC Hebert for the Canadian Critical Care Trials Group. Resuscitating patients with early severe sepsis: a Canadian multicentre observational study. Can J Anaesth. 2007 Oct;54(10):790-8
R Zarychanski, Y Chen, CN Bernstein, PC Hebert. Colorectal cancer screening and the role of the family physician. CMAJ 2007 Sep 11;177(6):593-7.
Deangelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hebert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van Der Weyden MB, Verheugt FW. Clinical Trial Registration: Looking Back and Moving Ahead. N Engl J Med. 2007 Jun 4 (In press).
Heels-Ansdell D, Zytaruk N, Hebert PC, Blythe D, Rischbieth A, Menon K, Erikson S, Fowler R, Marshall JC, Cook DJ for the CCCTG. Enrolment of ICU patients into clinical studies: Interim survey report of CCCTG & ANZICS-CTG. Am Rev Crit Care Med 2007; 175:A508d.
ID Graham, J Logan, CL Bennett, J Presseau, AM O'Connor, SL Mitchell, JM Tetroe, A Cranney, PC Hebert, SD Aaron. Physicians' intentions and use of three patient decision aids. BMC Medical Informatics and Decision Making 2007, 7:20.
McIntyre LA, Hebert PC, Fergusson D, Cook DJ, Aziz A. A survey of Canadian intensivists' resuscitation practices in early septic shock. Crit Care. 2007 July 10;11(4):R74.
B Hutton, R Sharma, D Fergusson, A Tinmouth, PC Hebert, J Jamieson, M Walker. Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review. BJOG, 2007; 114:134-142.
Shehata N, Naglie G, Alghamdi AA, Callum J, Mazer CD, Hebert P, Streiner D, Wilson K. Risk factors for red cell transfusion in adults undergoing coronary artery bypass surgery: a systematic review. Vox Sang. 2007 Jul;93(1):1-11.
Hebert PC, Stanbrook M, Sibbald B, Flegel K, MacDonald N, Attaran A. Progressive licensing needs progressive open debate. CMAJ. 2007 Jun 19;176(13):1801, 1803
Hebert PC, Tinmouth A, Corwin HL. Controversies in RBC transfusion in the critically ill. Chest. 2007 May;131(5):1583-90.
Lacroix J, Hébert PC, Hutchison JH, Hume H, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ, on behalf of the TRIPICU investigators, for the Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Transfusion Strategies for patients in Pediatric Intensive Care Units (TRIPICU) study - A noninferiority trial. N Engl J Med 2007 Apr 19;356(16):1609-19.
Tinmouth A, Hebert P. Interventional trials: an overview of design alternatives. Transfusion 2007 Apr;47(4):565-7.
Turgeon AF, Hutton B, Fergusson DA, McIntyre L, Tinmouth AA, Cameron DW, Hebert PC. Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsis. Ann Intern Med. 2007 Feb 6;146(3):193-203.
Ammerman DJ, Watters J, Clinch JJ, Hebert PC, Wilson KG, Morris DB, Fergusson D. Exploring quality of life for patients undergoing major surgery: the perspectives of surgeons, other healthcare professionals, and patients. Surgery. 2007 Jan;141(1):100-9.
Marshall SC, Gray D, Wilson KG, Yelle JD, Hebert P, O'Rourke K, Jamshidi M. A prospective study to validate an impairment questionnaire for major trauma survivors. Am. J.Phys. Med. Rehabil. 2007 Feb;86(2):114-24.
Wilson K, Graham I, Dornan C, Ricketts M, Laupacis A, Hebert P. Variant Creutzfldt-Jakob Disease and the Canadian Blood Supply After the tainted blood tragedy. Soc Sci Med. 2007 Jan;64(1):174-85.