Complete List of Publications

1.      Pakuts, A.P., R.J. Parks, C.J. Paul, S.J. Bujaki and R.W. Mueller (1990) Ketoconazole induced hepatic lysosomal phospholipidosis: the effect of concurrent barbiturate treatment.  Res. Commun. Chem. Pathol. Pharmacol. 67:55-62.
2.      Fisher, C.A., R.J. Parks, M.L. Lauzon and D.H. Evans (1991) Heteroduplex DNA formation is associated with replication and recombination in poxvirus infected cells. Genetics 129:7-18.
3.      Parks, R.J. and D.H. Evans (1991) Marker effects associated with the recom­bination of insertion and deletion mutations in poxvirus infected cells.  Virol. 184:299-309.
4.      Parks, R.J. and D.H. Evans (1991) Effect of marker distance and orientation on recombinant formation in poxvirus infected cells.  J. Virol. 65:1263-1272.
5.      Parks, R.J., P.J. Krell, J.B. Derbyshire and E. Nagy (1994) Studies of Fowlpox virus recombination in the generation of recombinant vaccines.  Virus Res. 32:283-297.
6.      Parks, R.J., B. Lichtey, C. Karakis and D.H. Evans (1994) Characterization of the Shope fibroma virus DNA ligase gene.  Virol. 202:642-650. 

1996
7.      Palaniyar, N., C. Fisher, R. Parks and D.H. Evans (1996) SFV topoisomerase: sequence specificity in a genetically mapped interval.  Virol. 221:351-354.
8.      Parks, R.J. and D.H. Evans (1996) The effect of transcription on genetic recombination in poxvirus-infected cells.  Virus Res. 41:11-23.
9.      Parks, R.J., L Chen, M. Anton, U. Sankar, M. Rudnicki and F.L. Graham (1996) A helper?dependent adenovirus vector system: removal of helper virus by Cre?mediated excision of the viral packaging signal.  Proc. Natl. Acad. Sci. U.S.A. 93:13565?13570.

1997
10.    Parks, R.J.and F.L. Graham (1997) A helper?dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging.  J. Virol. 71:3293?3298.

1998
11.    Scheidner, G., N. Morral, R.J. Parks, Y. Wu, S.C. Koopmans, C. Langston, F.L. Graham, A.L. Beaudet and S. Kochanek (1998) Genomic DNA transfer with a high capacity adenovirus vector results in improved in vivo expression and decreased toxicity.  Nature Genet. 8:180-183.
12.    Morsy, M.A., M.-C. Gu, S. Motzel, J. Zhao, L. Franlin, J. Lin, H. Allan, R.J. Parks, F.L. Graham, S. Kochanek, A.J. Bett and C.T. Caskey (1998) An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene.  Proc. Natl. Acad. Sci. USA 95:7866-7871.
13.    Parks, R.J., C.F. Winchcombe-Forhan, A.M. DeLange X. Xing and D.H. Evans (1998) DNA ligase gene disruptions can depress viral growth and replication in poxvirus?infected cells. Virus Res.56:135?147.
14.    Morral, N., R.J. Parks, H. Zhou, C. Langston, G. Scheidner, J. Quinones, F.L. Graham, S. Kochanek and A.L. Beaudet (1998) High doses of a helper-dependent adenoviral vector yield supraphysiological levels of a₁-antitrypsin with negligible toxicity. Human Gene Ther. 9:2709?2716.

1999
15.    Recchia, A., R.J. Parks, S. Lamartina, C. Toniatti, L. Pieroni, F. Palombo, G. Ciliberto, R. Cortese, N. LaMonica, S. Colloca (1999) Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector. Proc. Natl. Acad. Sci. USA.  96:2615-2620.
16.    Pastore, L., N. Morral, R. Garcia, H. Zhou, R.J. Parks, S. Kochanek, F.L. Graham, B. Lee, and A.L. Beaudet (1999) Use of tissue-specific promoter reduces immune response to the transgene in adenoviral vectors.  Human. Gene Ther. 10:1773-1781.
17.    Morral, N., W. O’Neal, K. Rice, M. Leland, J. Kaplan, P.A. Piedra, H. Zhou, R.J. Parks, R. Velji, E. Aguilar-Cordova, S. Wadsworth, F.L. Graham, S. Kochanek, K.D. Carey, A.L. Beaudet (1999) Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc. Natl. Acad. Sci. USA 96:12816?21.
18.    Ng, P., R.J. Parks, D. Cummings, C. Evelegh, U. Sankar, and F.L. Graham (1999) A high?efficiency Cre/loxP?based system for construction of adenoviral vectors.  Hum Gene Ther. 10:2667?2672.
19.    Parks, R.J., C.M. Evelegh, and F.L. Graham (1999) Use of helper-dependent adenoviral vectors of alternative serotype permits repeat vector administration. Gene Therapy.  6:1565-1573.
20.    Parks, R.J., J.L. Bramson, Y. Wan, C.L. Addison, and F.L. Graham (1999) Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors. J. Virol. 73:8027-8034.
21.    Parks, R.J. and J. L. Bramson (1999) Adenoviral vectors: prospects for gene delivery to the central nervous system.  Gene Therapy 6:1349-1350. 

2000
22.    Ng, P., R.J. Parks, D.T. Cummings, C.M. Evelegh and F. L. Graham (2000) An enhanced system for construction of adenoviral vectors by the two plasmid rescue method.  Hum. Gene Ther. 10:2667-2672.
23.    O’Neal, W.K., H. Zhou, N. Morral, C. Langston, R.J. Parks, F.L. Graham, S. Kochanek, A.L. Beaudet (2000)  Toxicity associated with repeated administration of first-generation adenoviral vectors is not induced by a helper-dependent vector. Molecular Medicine 6:179-195.
24.    Cregan, S.P., J. MacLaurin, T.F. Gendron, S.M. Callaghan, D.S. Park, R.J. Parks, F.L. Graham, P. Morley and R.S. Slack (2000) Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons.  Gene Therapy 7:1200-1209.
25.    Parks, R.J.  (2000) Improvements in adenoviral vector technology: overcoming barriers for gene therapy.  Clinical Genetics 58:1-19.

2001
26.    Ng, P., C. Beauchamp, C. Evelegh, R. Parks, and F.L. Graham (2001) Development of a FLP/frt system for generating helper-dependent adenoviral vectors.  Molecular Therapy 3:809-815.

2002
27.    Hubberstey, A.V., M. Pavliv and R.J. Parks (2002) Cancer therapy utilizing an adenoviral vector expressing only E1A.  Cancer Gene Therapy 9:321-329.
28.    Amalfitano, A., and R.J. Parks (2002) Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapy. Current Gene Therapy 2:111-133.
29.    Ng, P., R.J. Parks, and F.L. Graham (2002) Preparation of helper-dependent adenoviral vectors. Methods Mol Med. 2002;69:371-88. 

2003
30.    Didonato, C.J., R.J. Parks, and R. Kothary (2003) Development of a gene therapy strategy for the restoration of survival motor neuron (SMN):  implications for SMA therapy.  Human Gene Therapy 14:179-188.
31.    Wellington, C.L., L.R. Brunham, S. Zhou, R. Singaraja, H. Visscher, A. Gelfer, C. Ross, E. James, G. Liu, M. Huber, Y.-Z. Yang, R.J. Parks, A. Groen, J. Najib-Fruchart, and M.R. Hayden (2003) Alterations of plasma lipids in mice via adenoviral mediated hepatic overexpression of human ABCA1.  J. Lipid Res. 44:1470-1480.
32.    Ross, P.J. and R.J. Parks (2003) Oncolytic adenovirus:  getting there is half the battle.  Molecular Therapy 8:705-706. 

2004
33.    Sargent, K., C. Evelegh, F.L. Graham, and RJ Parks (2004) Development of a size restricted pIX helper virus for amplification of helper dependent adenovirus vectors. Gene Therapy 11:504-511.
34.    Bramson, J.L., N. Grinshtein, R.A. Meulenbroek, J. Lunde, D. Kottachchi, I.A. Lorimer, B.J. Jasmin, and R.J. Parks (2004) Helper-dependent adenoviral vectors containing modified fibre for improved transduction of developing and mature muscle cells. Human Gene Therapy 15:179-188.
35.    Meulenbroek, R.M., K.S. Sargent, J. Lunde, B.J. Jasmin, and R.J. Parks (2004) Use of adenovirus pIX to display large polypeptides in the virion – generation of fluorescent virus through the incorporation of pIX-GFP.  Mol. Ther. 9:617-624.
36.    Sargent, K.L., R.A. Meulenbroek, and R.J. Parks (2004) Activation of adenoviral gene expression by protein IX is not required for efficient virus replication. J. Virol. 78:5032-5037.
37.    Muruve, D.A., M.J. Cotter, A.K. Zaiss, L.R. White, Q. Liu, T. Chan, S.A. Clark, P.J. Ross, R.A. Meulenbroek, G.M. Maelandsmo, and R.J. Parks (2004) Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses J. Virol. 78:5966-5972.
38.    Chambers, K.A., R.J. Parks, and J.B. Angel (2004) Disruption of map kinase activation and nuclear factor binding to the IL-12 p40 promoter in HIV-infected myeloid cells.  Clinical and Experimental Immunology 137:329-340.
39.    Huh, M.S., M.H. Parker, A. Scime, A. Berns, R.J. Parks, and M.A. Rudnicki (2004) Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation.  J. Cell. Biol. 166:865-876.
40.    Brown, R.J., A. Gauthier, R.J. Parks, R. McPherson, D.L. Sparks, J.R. Schultz, and Z. Yao (2004) Severe hypoalphalipoproteinuria in mice expressing human hepatic lipase deficient in binding to heparin sulfate proteoglycan. J. Biol. Chem. 279:42403-42409.

2005 
41.    Maelandsmo, G.M., P.J. Ross, M. Pavliv, R.A. Meulenbroek, C. Evelegh, F.L. Graham, and R.J. Parks (2005) Use of a murine secreted alkaline phosphatase as a non-immunogenic reporter gene in mice J. Gene Medicine 7:307-315.
42.    Parks, R.J. (2005) Adenovirus protein IX:  a new look at an old protein.  Molecular Therapy 11:19-25.
43.    Chakkalakal, J.V., J. Thompson, R.J. Parks, and B.J. Jasmin  (2005) Molecular, cellular and pharmacological therapies for Duchenne/Becker muscular dystrophies.  FASEB J. 19:880-891.
44.    Deschênes-Furry, J.L., G. Bélanger, J. Mwanjewe, J.A. Lunde, R.J. Parks, N. Perrone-Bizzozero, and B.J. Jasmin (2005) The RNA-binding protein HuR binds to acetylcholinesterase transcripts and regulates their expression in differentiating skeletal muscle cells.  Journal of Biological Chemistry 280:25361-25368.
45.    Yakubchyk, Y., H. Abramovici, C. Obagi, R.J. Parks, M.K. Topham, and S.H. Gee (2005) Regulation of neurite outgrowth in N1E-115 cells through spatial control of diacylglycerol kinase-? and Rac1 by syntrophins.  Molecular and Cellular Biology 25:7181-7192.

2006
46.    Michaud, J.-L.R., K.M. Chaisson, R.J. Parks, and C.R.J. Kennedy (2006)  FSGS-associated mutant a-actinin-4 (K256E) impairs cytoskeletal dynamics in podocytes.  Kidney International 70:1054-1061.  

2007
47.    Deschênes-Furry, J.L., K. Mousavi, F. Bolognani, R.L. Neve, R.J. Parks, N.I. Perrone-Bizzozero, and B.J. Jasmin (2007) The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its gene expression following axotomy.  J. Neurosci. 27:665-75.

2008
48.    Muruve, D.A., V.Petrilli, A.K. Zaiss, L.R. White, S.A. Clark, P.J. Ross, R.J. Parks, and J. Tschopp (2008) Recognition of cytosolic microbial and host DNA by the inflammasome triggers an innate immune response. Nature 452:103-107.

2009
49.    Smith, A.C., K.L. Poulin, and R.J. Parks (2009) DNA genome size affects the stability of the adenovirus virion.  J. Virol. 83:2025-2028.
50.    Abramovici, H., P. Mojtabaie, R.J. Parks, X.-P. Zhong, G.A. Koretzky, M.K. Topham and S.H. Gee (2009) Defective cell migration and membrane ruffling in diacylglycerol kinas?e-z-deficient fibroblasts due to decreased Pak1 phosphorylation and impaired dissociation of Rac1 from its inhibitor RhoGDI. Mol. Biol. Cell. 20:2049-59.
51.    Ross P.J., M.A. Kennedy and R.J. Parks (2009) Host cell detection of non-coding stuffer DNA contained in helper-dependent adenovirus vectors leads to epigenetic repression of transgene expression.  J. Virol. 83:8409-17.
52     Ross, P.J. and R.J. Parks (2009) Construction and characterization of adenovirus vectors.  Cold Spring Harbor Protocols doi:.1101/pdb.prot5011
53.    Storbeck, C.J., S. Wagner, P. O’Reilly, M. McKay, R.J. Parks, H. Westphal and L.A. Sabourin (2009) The Ldb1 and Ldb2 transcriptional co-factors interact with the Ste20-like kinase SLK and regulate cell migration.  Mol. Biol. Cell. 20:4174-4182.
54.    Kennedy, M.A. and R.J. Parks (2009) Adenovirus virion stability and the viral genome: size matters. Mol. Ther. 17:1664-1666.
55.    Venderova, K., G. Kabbach, E. Abdel-Messih, Y. Zhang, R.J. Parks, Y. Imai, S. Gehrke, J. Ngsee, M.J. LaVoie, R. Slack, Y. Rao, Z. Zhang, B. Lu, M.E. Haque, and D.S. Park (2009) Leucine-rich repeat kinase interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson’s disease.  Human Molecular Genetics 18:4390-404.
56     Finn, J.D., J. Bassett, J.B. Millar, N. Grinshtein, T.C. Yang, R. Parsons, C. Evelegh, Y. Wan, R.J. Parks, and J.L. Bramson (2009) Persistence of transgene expression influences CD8+ T cell expansion and maintenance following immunization with recombinant adenovirus. J. Virol 83:12027-36.

2010
57.    Sundaram, M, S. Zhong, M.-B. Khalil, P.H. Links, Y. Zhao, J. Iqbal, M. Hussain, R.J. Parks, Y. Wang, and Z. Yao (2010) Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid rich conditions.  J. Lipid Res. 51:150-161.
58     Boucher, J.G., K.A. Parato, F. Frappier, W. Ma, N. Gajanayaka, R.J. Parks, A. Kumar, J.B Angel (2010) Disparate regulation of LPS-induced MAPK signalling and IL-12p40 expression between different myeloid cell types with and without HIV infection.  Viral Immunology 23:17-28.
59.    Li, L., S. Wang, A. Jezierski, L. Moalim-Nour, K. Mohib, R.J. Parks, S.F. Retta, L. Wang (2010) A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates cell fate decisions of human embryonic stem cells. Stem Cells 28:247-57.
60.    Poulin, K.L., R.M. Lanthier, A.C. Smith, C. Christou, M. Risco-Quiroz, K.L. Powell, R.W. O’Meara, R. Kothary, I.A. Lorimer, R.J. Parks (2010) Retargeting of adenovirus vectors through fusion of a single-chain or single-domain antibody to capsid protein IX. J Virol. 84:10074-86.

2011
61.    Christou, C., and R.J. Parks (2011) Rational design of murine secreted alkaline phosphatase for enhanced performance as a reporter gene in mouse gene therapy preclinical studies.  Human Gene Therapy 22:499-506.
62.    Bamji-Mirza, M., M. Sundaram, S. Zhong, E.F. Yao, R.J. Parks and Z. Yao (2011) Secretion of lipid-poor VLDL particles from McA-RH7777 cells expressing human hepatic lipase. J Lipid Res. 52:540-548.
63.    Beug, S.T., R.J. Parks, H.M. McBride and V.A. Wallace (2011) Trafficking of the Sonic hedgehog morphogen to the regulated secretory pathway in mammalian neurons. Mol Cell Neurosci 46:583-596.
64.    Ross, P.J., M.A. Kennedy, C. Christou, M. Risco Quiroz, K.L. Poulin and R.J. Parks (2011) Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression.  J. Virol. 85:3950-3958.
65.    Qin, W.­, M. Sundaram, Y. Wang, H. Zhou, S. Zhong, C.-C. Chang, S. Manhas, E.F. Yao, R.J. Parks, P.J. McFie, S.J. Stone, Z.G. Jiang, C. Wang­, D. Figeys, W. Jia­, and Z. Yao (2011) Missense mutation in APOC3 within the C-terminal lipid-binding domain of human apoCIII results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins.  J. Biol. Chem. 286:27769-80.
66.    Poulin, K.L., G. Tong, O. Vorobyova, M. Pool, R. Kothary, R.J. Parks (2011) Use of Cre/loxP recombination to swap cell binding motifs on the adenoviral capsid protein IX.  Virology 420:146–155.
67.    Anker, J.J., S. Brimijoin, Y. Gao, L. Geng, N.E. Zlebnik, R.J. Parks, and M.E. Carroll (2011) Cocaine hydrolase encoded in viral vectors blocks the reinstatement of cocaine seeking in rats for 6 months.  Biological Psychiatry (in press).
68.    Giberson, A.N., A.R. Davidson, and R.J. Parks (2011) Chromatin structure of adenovirus DNA throughout infection.  Nucleic Acids Res.  (in press).