Kursad Turksen, PhD

kturksen@ohri.ca

Senior Scientist, Regenerative Medicine, Ottawa Hospital Research Institute

Assistant Professor, Biochemistry, University of Ottawa

Research Interests

My research interests are 1. to elucidate the molecular mechanisms underlying formation of the epidermis of mouse skin, and 2. to understand how these processes go awry in skin diseases.

Major Research Activities

1.how growth factors regulate the commitment of epidermal progenitors in the differentiating embryonic stem (R1) cells,

2. identifying and characterizing genes that determine the pathway leading from very early progenitors (K8-positive) to late epidermal progenitors (K5/K14-positive), using the gene trap and differential display techniques.

Recent Publications:

Most Recent Publications (provided by The Ottawa Hospital Library Database)

Jezierski A;Gruslin A;Tremblay R;Ly D;Smith C;Turksen K;Sikorska M;Bani-Yaghoub M;, (2010 Mar 11), Probing Stemness and Neural Commitment in Human Amniotic Fluid Cells, Stem Cell Rev, Vol.6, Issue 2, 199-214 -> view abstract

Turksen K;, (2010 Jan), Wasted salts and wasted bodies: new insight into the role of claudin 7 in the kidney, Am J Physiol Renal Physiol, Vol.298, Issue 1, F22-F23

Arabzadeh A;Troy TC;Turksen K;, (2009 Nov), Insights into the role of the calcium sensing receptor in epidermal differentiation in vivo, Mol Biotechnol, Vol.43, Issue 3, 264-272 -> view abstract

Troy TC;Arabzadeh A;Lariviere NM;Enikanolaiye A;Turksen K;, (2009), Dermatitis and aging-related barrier dysfunction in transgenic mice overexpressing an epidermal-targeted claudin 6 tail deletion mutant, PLoS ONE, Vol.4, Issue 11, e7814 -> view abstract

Arabzadeh A;Troy TC;Turksen K;, (2008 Jan), Claudin expression modulations reflect an injury response in the murine epidermis, J Invest Dermatol, Vol.128, Issue 1, 237-240 -> view abstract

Troy TC;Arabzadeh A;Enikanolaiye A;Lariviere N;Turksen K;, (2008), Immunohistochemistry on paraffin sections of mouse epidermis using fluorescent antibodies, J Vis Exp, Vol.-11, Issue 8-Jan, pii:552 -> view abstract

Turksen K;, (2008), Reviewing stem cells: a new day, Stem Cell Rev, Vol.4, Issue 1, 1 -> view abstract

Troy TC;Arabzadeh A;Yerlikaya S;Turksen K;, (2007 Nov), Claudin immunolocalization in neonatal mouse epithelial tissues, Cell and Tissue Research, Vol.330, Issue 2, 381-388 -> view abstract

Troy TC;Turksen K;, (2007 Jun), The targeted overexpression of a Claudin mutant in the epidermis of transgenic mice elicits striking epidermal and hair follicle abnormalities, Molecular Biotechnology, Vol.36, Issue 2, 166-174 -> view abstract

Troy TC;Li Y;O'Malley L;Turksen K;, (2007 Feb), The temporal and spatial expression of Claudins in epidermal development and the accelerated program of epidermal differentiation in K14-CaSR transgenic mice., Gene Expression Patterns, Vol.7, Issue 4, 423-430 -> view abstract

Books

Turksen, K. (Editor). Embryonic Stem Cell Protocols Volume I: Isolation And Characterization (Methods in Molecular Biology). 2006. Humana Press.

Turksen, K. (Editor). Embryonic Stem Cell Protocols Volume II: Differentiation Models (Methods in Molecular Biology). 2006. Humana Press.

Turksen, K. (Editor). Human Embryonic Stem Cell Protocols (Methods in Molecular Biology). 2006. Humana Press.

Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).