Folic Acid in the Second Trimester and adverse pregnancy outcomes

Principal Investigator:

Dr Shi Wu Wen, University of Ottawa

Co-Investigators:

Dr Mark Walker, University of Ottawa
Dr Sherry Perkins, University of Ottawa
Dr Ron Sigal, University of Ottawa
Dr Marc Roger, University of Ottawa

Funding Agency:

CIHR

Objectives:

1. To assess the association between serum folate in the second trimester and the occurrence of placenta- mediated adverse pregnancy outcomes: preeclampsia, placental abruption, fetal death and fetal growth restriction.
2. To determine if the risk of placenta-mediated adverse pregnancy outcomes among carriers of the defective MTHFR gene increase compared with non carriers.
3. To determine the correlation between low maternal serum folate in the second trimester, the defective MTHFR gene, elevated fasting plasma homocysteine in the second trimester and the increased risk of placenta-mediated adverse pregnancy outcomes.

Recruitment Goal:

3000

Duration of Study:

October 2002 to October 2004