The Canadian Preterm Labour Nitroglycerin Trial

Official Site

Principal Investigator:

Dr Graeme Smith, Queen's University

Co-Investigators:

Dr Mark Walker, University of Ottawa
Dr. Rory Windrim, University of Toronto
Dr. Arne Ohlssen, University of Toronto
Dr. Karel O'Brien, University of Toronto

Funding Agency:

CIHR

Objectives:

  1. To determine the effectiveness of transdermal nitroglycerine (GTN) in reducing preterm delivery thereby reducing neonatal morbidity.
  2. To determine the incidence of neonatal morbidity as a result of prolongation of pregnancy.
  3. To determine if GTN reduces the incidence of delivery during the 48 hours of treatment and/or reduces the incidence of preterm delivery ie. delivery <34 week gestation.
  4. To determine if GTN has any significant maternal and/or fetal side effects.

Duration of Study:

May 2001 to May 2006