Disease models

Research News


Creating a new mouse model to study COVID-19 lung disease
June 4, 2020 - Researchers are working to develop a mouse model of COVID-19 that mimics the severe lung disease seen in humans. The lack of good, accessible animal models of this disease is severely limiting research around the world.
COVID-19 research moving at ‘lightning speed’, thanks to generous community support
May 8, 2020 - Researchers at The Ottawa Hospital are working around the clock to advance more than 50 potentially life-saving research projects to support the world-wide effort to find better ways to treat and prevent COVID-19. Now, nine of these projects have bee
Researchers use lab-grown human tissues to understand secrets of COVID-19 infection, identify possible treatments
April 29, 2020 - A team of Ontario researchers is using 3D lab-grown human tissue models to understand why COVID-19 makes some patients severely ill. They also hope to identify drugs that can reduce the severity of the infection.
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Researchers


Name Scientific appointment Diseases, conditions and populations of interest Research and clinical approaches
Addison, Christina
PhD
Senior Scientist
(Cancer Therapeutics)
Bone and joint degeneration, Cancer, Lung cancer, Lung disease, Pancreatic cancer, Prostate cancer, Breast cancer Basic research, Clinical research, Cohort studies, Disease models, Drug development, Genetics, Imaging, Model organisms, Translational research, Molecular and cellular biology
Albert, Paul
PhD
Senior Scientist
(Neuroscience)
Mental health, Vascular cognitive impairment, Anxiety, Depression, Intellectual disabilities, Parkinson's, Schizophrenia, Stroke, Suicide Basic research, Epigenetics, Exercise, Gene expression, Translational research, Disease models, Epigenetics, Genetics, Imaging, Molecular and cellular biology, Optogenetics, Transgenic/knockout models
Ardolino, Michele
PhD
Scientist
(Cancer Therapeutics)
Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma Basic research, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Aviv, Richard
MBChB, FRCR (UK), FRCPC, dABR
Clinician Investigator
(Neuroscience)
Brain and neuromuscular disease, Brain cancer, Head and neck cancer, Multiple sclerosis, Stroke, Subarachnoid hemorrhage, Traumatic brain injury, Vascular cognitive impairment, Vascular, heart and metabolic disease 3D printing, Artificial intelligence and data science, Basic research, Big data, Bioinformatics, Biomarkers, Clinical research, Cluster randomized trials, Disease models, Health economics, Health technology, Imaging, Patient safety, Quality Improvement, Translational research
Brand, Marjorie
PhD
Senior Scientist
(Regenerative Medicine)
Blood cancer, Sickle cell anemia, Thalassemia, Vascular, heart and metabolic disease Artificial intelligence and data science, Basic research, Bioinformatics, Disease models, Epigenetics, Gene expression, Genomics, Imaging, Model organisms, Molecular and cellular biology, Proteomics, Stem cells, Systems biology, Transgenic/knockout models
Burger, Dylan
PhD
Senior Scientist
(Chronic Disease)
Aging, Chronic disease, Diabetes, Hypertension, Kidney disease, Type 1 diabetes, Vascular cognitive impairment, Vascular, heart and metabolic disease Basic research, Biomarkers, Disease models, Imaging, Molecular and cellular biology, Pharmacology, Proteomics, Regenerative medicine, Stem cells, Transgenic/knockout models, Translational research
Burns, Kevin
MD CM, FRCPC
Senior Scientist
(Chronic Disease)
Diabetes, Kidney disease, Vascular, heart and metabolic disease Basic research, Biomarkers, Cell therapy, Clinical research, Disease models, Gene expression, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models, Translational research
Chen, Hsiao-Huei
PhD
Senior Scientist
(Neuroscience)
Autism, Depression, Mental health, Alzheimer's, Alzheimer's, Anxiety, Diabetes, Obesity, Schizophrenia, Stroke, Vascular, heart and metabolic disease Disease models, Gene expression, Optogenetics, Transgenic/knockout models, Basic research, Molecular and cellular biology, Translational research
Gray, Douglas
PhD
Senior Scientist
(Cancer Therapeutics)
Aging, Cancer, Lung cancer, Parkinson's Basic research, Disease models, Genomics, Imaging, Transgenic/knockout models, Genetics, Model organisms, Molecular and cellular biology
Kothary, Rashmi
Ph.D.
Senior Scientist
(Regenerative Medicine)
Neuromuscular disease, Amyotrophic lateral sclerosis, Dystonia, Multiple sclerosis, Muscular dystrophy, Spinal muscular atrophy Basic research, Disease models, Drug development, Epigenetics, Epigenetics, Gene therapy, Genetics, Imaging, Lipidomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Transgenic/knockout models, Translational research
Lacoste, Baptiste
PhD
Scientist
(Neuroscience)
Stroke, Vascular cognitive impairment, Autism Basic research, Disease models, Gene expression, Genomics, Stem cells, Genetics, Imaging, Model organisms, Molecular and cellular biology, Transgenic/knockout models
Lalu, Manoj
MD, PhD, FRCPC
Associate Scientist
(Clinical Epidemiology)
Blood cancer, COVID-19, Heart disease, Stroke, Vascular, heart and metabolic disease Basic research, Cell therapy, Clinical research, Clinical trials, Disease models, Health research methods, Model organisms, Patient engagement, Regenerative medicine, Stem cells, Translational research
Liu, Johné
PhD
Senior Scientist
(Chronic Disease)
Aging, Cancer, Infertility, Maternal and fetal health, Pregnancy, Women's health Basic research, Clinical research, Clinical trials, Disease models, Drug development, Translational research
Lorimer, Ian
PhD
Senior Scientist
(Cancer Therapeutics)
Brain and neuromuscular disease, Brain cancer, Cancer Basic research, Cancer biotherapeutics, Cell therapy, Disease models, Molecular and cellular biology, Translational research
Megeney, Lynn
PhD
Senior Scientist
(Regenerative Medicine)
Heart disease, Muscular dystrophy Stem cells, Disease models, Proteomics, Drug development
Mei, Shirley
PhD, MSc
Investigator
(Regenerative Medicine)
COVID-19, Septic shock Basic research, Biomarkers, Cell therapy, Critical care, Disease models, Epigenetics, Gene therapy, Knowledge translation and implementation research, Molecular and cellular biology, Regenerative medicine, Stem cells
Picketts, David
Ph.D.
Senior Scientist
(Regenerative Medicine)
Autism, Brain and neuromuscular disease, Intellectual disabilities, Multiple sclerosis, Stroke, Vision Basic research, Disease models, Epigenetics, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models
Rudnicki, Michael
OC, PhD, FRS, FRSC
Program Director and
Senior Scientist
(Regenerative Medicine)
Muscular dystrophy, Neuromuscular disease Basic research, Bioinformatics, Disease models, Epigenetics, Genetics, Genomics, Model organisms, Molecular and cellular biology, Proteomics, Regenerative medicine, Stem cells, Transgenic/knockout models
Sabourin, Luc
PhD
Senior Scientist
(Cancer Therapeutics)
Breast cancer, Muscular dystrophy, Skin cancer Basic research, Disease models, Drug development, Gene expression, Genetics, Molecular and cellular biology, Proteomics, Stem cells, Transgenic/knockout models
Schlossmacher, Michael
MD, DABPN, FRCPC
Program Director and
Senior Scientist
(Neuroscience)
Aging, Brain and neuromuscular disease, Chronic disease, Crohn's, Dementia, Inflammatory bowel syndrome, Dementia, Parkinson's Basic research, Biomarkers, Cohort studies, Disease models, Drug development, Genetics, Lipidomics, Molecular and cellular biology, Proteomics, Risk assessment, Transgenic/knockout models, Translational research
Tsilfidis, Catherine
PhD
Senior Scientist
(Neuroscience)
Vision, Retinal disease, Glaucoma Molecular and cellular biology, Disease models
Vanderhyden, Barbara
PhD
Senior Scientist
(Cancer Therapeutics)
Cancer, Infertility, Ovarian cancer, Women's health Basic research, Bioinformatics, Biomarkers, Cancer biotherapeutics, Disease models, Drug development, Epigenetics, Gene expression, Genomics, Immunotherapy, Model organisms, Molecular and cellular biology, Oncolytic viruses, Stem cells, Transgenic/knockout models, Translational research, Viral therapy
Wang, Jing
Ph.D.
Senior Scientist
(Regenerative Medicine)
Alzheimer's, Multiple sclerosis, Stroke Cell therapy, Disease models, Epigenetics, Imaging, Molecular and cellular biology, Regenerative medicine, Stem cells, Transgenic/knockout models