Cognitive Health in Multiple Sclerosis Research Lab

Lisa Walker profile picture

Contact Information

Lisa Walker, PhD, C.Psych
613-737-8894
lwalker@toh.ca

Fax -613-737-8895



ORCID logo https://orcid.org/0000-0001-5865-7257

Publications

Selected Publications

Berard, J.A. & Walker, L.A.S. (2022). Validity and sensitivity of Canadian normative data for the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery. Multiple Sclerosis and Related Disorders. (published on-line 10 May 2022). https://doi.org/10.1016/j.msard.2022.103865

Berard, J.A., Freedman, M.S., Marrie, R.A., Marriott, J.J., Atkins, H.L., Szwajcer, D., Courtman, D.W., Thebault, S. & Walker, L.A.S. (2022). The impact of mesenchymal stem cell therapy on cognition in individuals with multiple sclerosis. Multiple Sclerosis and Related Disorders, 61, 1-8, 103779 (published on-line 27 March 2022). https://doi.org/10.1016/j.msard.2022.103779

Berard, J.A. & Walker, L.A.S. (2021). Increasing the clinical utility of the Paced Auditory Serial Addition Test: Normative data for standard performance, dyad and cognitive fatigability scoring. Cognitive and Behavioral Neurology, 34(2), 107-116. https://doi:10.1097/WNN.0000000000000268. PMID: 34074865

Walker, L.A.S., Lindsay-Brown, A.P. & Berard, J.A. (2019). Cognitive fatigability interventions in neurological conditions: A systematic review. Neurology and Therapy, 8(2), 251-271. (published on-line 4 October 2019). http://link.springer.com/article/10.1007/s40120-019-00158-3. PMID: 31586303

Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S. (2016; 6-12 Aug). Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6 PMID: 27291994

All Other Publications

1. Hamwi, M.*, Thebault, S.*, Melkus, G., Auriat, A., Pham, A., Carrington, A., Thornhill, R., Walker, L.A.S., Chakraborty, S., Torres, C., Zhang, L., Atkins, H., Freedman, M. & Aviv, R. (2023).  MRI graph parameters are longitudinal markers of neuronal integrity in multiple sclerosis.  Multiple Sclerosis and Related Disorders. (published on-line 11 October 2023) (* denotes co-first authors) https://doi.org/10.1016/j.msard.2023.105066

2. Walker, L.A.S., Berard, J.A., Islam, T., Pilutti, L.A., Morrow, S.A. & Finlayson, M. (2022).  Development of a behavioural intervention for cognitive fatigability in multiple sclerosis: Protocol for a pilot and feasibility study.  Frontiers in Rehabilitation Sciences, 3:999266. (published on-line 16 November 2022). https://www.frontiersin.org/articles/10.3389/fresc.2022.999266/full

3. MacAdam, E., Berard, J.A. & Walker, L.A.S. (2022).  Cognition and cognitive fatigability: Predicting employment status in multiple sclerosis.  Canadian Journal of Neurological Sciences, 1-6.  https://doi.org/10.1017/cjn.2022.309

4. Berrigan, L.I., LeFevre, J., Rees, L.M., Berard, J.A., Francis, A., Freedman, M.S. & Walker, L.A.S. (2022).  The Symbol Digit Modalities Test and the Paced Auditory Serial Addition Test involve more than processing speed for persons with multiple sclerosis and controls.  Multiple Sclerosis and Related Disorders, 104229, 1-6. (published on-line 7 October 2022). https://doi.org/10.1016/j.msard.2022.104229.

5. Berard, J.A. & Walker, L.A.S. (2022).  Validity and sensitivity of Canadian normative data for the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery.  Multiple Sclerosis and Related Disorders. (published on-line 10 May 2022).  https://doi.org/10.1016/j.msard.2022.103865

6. Berard, J.A., Freedman, M.S., Marrie, R.A., Marriott, J.J., Atkins, H.L., Szwajcer, D., Courtman, D.W., Thebault, S. & Walker, L.A.S. (2022).  The impact of mesenchymal stem cell therapy on cognition in individuals with multiple sclerosis.  Multiple Sclerosis and Related Disorders, 61, 1-8, 103779 (published on-line 27 March 2022).  https://doi.org/10.1016/j.msard.2022.103779  

7. Walker, C. S., Berard, J.A. & Walker, L.A.S. (2021).  Validation of discrete and regression-based performance and cognitive fatigability normative data for the Paced Auditory Serial Addition Test in multiple sclerosis.  Frontiers in Neuroscience, 15:730817. (published on-line 15 November 2021). https://doi.org/10.3389/fnins.2021.730817.  

8. Agyemang, C., Berard, J.A. & Walker, L.A.S. (2021).  Cognitive fatigability in multiple sclerosis: How does performance decline over time on the Paced Auditory Serial Addition Test?  Multiple Sclerosis and Related Disorders, 54: 103130.  (published on-line 10 July 2021).  https://doi.org/10.1016/j.msard.2021.103130  PMID: 34273611  

9. Berard, J.A. & Walker, L.A.S. (2021).  Increasing the clinical utility of the Paced Auditory Serial Addition Test: Normative data for standard performance, dyad and cognitive fatigability scoring.  Cognitive and Behavioral Neurology, 34(2), 107-116.  https://doi:10.1097/WNN.0000000000000268. PMID: 34074865  

10. Ramani, S., Berard, J.A. & Walker, L.A.S. (2020).  The relationship between neurofilament light chains and cognition in neurological disorders: A scoping review. Journal of the Neurological Sciences. (published on-line 24 November 2020).  https://doi:10.1016/j.jns.2020.117229 . PMID: 33243431  

11. Thebault, S., Lee, H., Bose, G., Tessier, D., Abdoli, M., Bowman, M., Berard, J.A. Walker, L.A.S., Rush, C., MacLean, H., Booth, R. Narayanan, S., Arnold, D., Tabard-Cossa, V., Atkins, H., Bar-Or, A. & Freedman, M.S. (2020).  Neurotoxicity after haematopoietic stem cell transplant for multiple sclerosis.  Annals of Clinical and Translational Neurology. (published on-line 18 April 2020).  https://doi: 10.1002/acn3.51045.  PMID: 32304358  

12. Berard, J.A., Fang, Z., Walker, L.A.S., Lindsay-Brown, A., Osman, L., Cameron, I., Cruce, R., Cron, G.O., Freedman, M.S. & Smith, A.M. (2020).  Imaging cognitive fatigue in multiple sclerosis: Objective quantification of cerebral blood flow during a task of sustained attention using ASL perfusion fMRI.  Brain Imaging and Behavior, 14, 2417–2428 (published on-line 29 August 2019).  doi: 10.1007/s11682-019-00192-7. PMID: 31468375.  

13. Walker, L.A.S., Lindsay-Brown, A.P. & Berard, J.A. (2019).  Cognitive fatigability interventions in neurological conditions: A systematic review.  Neurology and Therapy, 8(2), 251-271.  (published on-line 4 October 2019).  http://link.springer.com/article/10.1007/s40120-019-00158-3. PMID: 31586303  

14. Berard, J.A., Smith, A.M. & Walker, L.A.S. (2019).  Predictive models of cognitive fatigue in multiple sclerosis.  Archives of Clinical Neuropsychology, 34 (1), 31-38. (published on-line 17 February 2018).  https://doi.org/10.1093/arclin/acy014. PMID: 29471423  

15. Walker, L.A.S., Gardner, C., Freedman, M.S., MacLean, H., Rush, C. & Bowman, M. (2019).  Research-to-practice gaps in multiple sclerosis care in one Canadian centre for those with subjective cognitive, mental health and psychosocial concerns.  International Journal of MS Care, 21, 243-248. (published on-line Dec. 4, 2018).  https://doi.org/10.7224/1537-2073.2017-090.  PMID: 31889928  

16. Darlington, P.J., Stopnicki, B., Touil, T., Doucet, J-S., Fawaz, L., Roberts, M.E., Boivin, M-N., Arbour, N., Freedman, M.S., Atkins, H.L., Bar-Or, A. for the Canadian MS/BMT Study Group (L.Walker - member of study group) (2018).  Natural killer cells regulate Th17 cells after autologous hematopoietic stem cell transplantation for relapsing remitting multiple sclerosis.  Frontiers in Immunology, 9, article 834.  (published on-line 07 May 2018).  Doi: 10.3389/fimmu.2018.00834.  PMID: 29867923  

17. Barbu, R.M., Berard, J.A., Gresham, L.M. & Walker, L.A.S. (2018).  Longitudinal stability of cognition in early phase relapsing-remitting multiple sclerosis: Does cognitive reserve play a role?  International Journal of MS Care, 20(4): 173-179 (published on-line Sept 11, 2017).  https://doi.org/10.7224/1537-2073.2016-073. PMID: 30150901  

18. Mioduszewski. O., MacLean, H., Poulin, P.A., Smith, A.M. & Walker, L.A.S. (2018).  Trait mindfulness and wellness in multiple sclerosis.  Canadian Journal of Neurological Sciences, 45(5), 580-582.  (published on-line 12 July 2018).  https://doi.org/10.1017/cjn.2018.51. PMID: 30234464  

19. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2018).  Revisiting cognitive reserve and cognition in multiple sclerosis: a closer look at the role of depression.  Multiple Sclerosis Journal, 24(2), 186-195 (published on-line 13 February 2017). http://journals.sagepub.com/doi/pdf/10.1177/1352458517692887  PMID: 28273771  

20. Berard, J.A., Smith, A.M. & Walker, L.A.S. (2018).  A longitudinal evaluation of cognitive fatigue in multiple sclerosis using the Paced Auditory Serial Addition Test (PASAT).  International Journal of MS Care, 20, 55-61 (first published on-line Jul 13, 2017).  https://doi.org/10.7224/1537-2073.2016-106.  PMID: 29670491  

21. Walker, L.A.S., Marino, D., Berard, J.A., Feinstein, A., Morrow, S.A., Cousineau, D. (2017).  Canadian normative data for Minimal Assessment of Cognitive Function in Multiple Sclerosis.  Canadian Journal of Neurological Sciences, 44, 547-555 (first published on-line Jul 7, 2017).  https://doi.org/10.1017/cjn.2017.199  PMID: 28683843  (Corrigendum – Canadian Journal of Neurological Sciences, 45(5), 604. https://doi.org/10.1017/cjn.2018.308)  

22. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2017).  Deconstructing the Symbol Digit Modalities Test in multiple sclerosis: The role of memory.  Multiple Sclerosis and Related Disorders, 17, 184-189.  http://dx.doi.org/10.1016/j.msard.2017.08.006. PMID: 29055455  

23. Walker, L.A.S., Bourque, P., Smith, A.M. & Warman Chardon, J. (2017).  Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.  Neuropsychology, 31(3), 292-303 (first published on-line Nov 21, 2016).  http://dx.doi.org/10.1037/neu0000322. PMID: 27869457  

24. Patel, V.P., Walker, L.A.S. & Feinstein, A. (2017).  Processing speed and distractibility in multiple sclerosis: the role of sleep.  Multiple Sclerosis and Related Disorders, 11, 40-42. http://dx.doi.org/10.1016/j.msard.2016.11.012  PMID: 28104254  
25. Stamenova, V., Jennings, J.M., Cook, S.P., Gao, F. Walker, L.A.S., Smith, A.M., Davidson, P.S.R. (2017).  Repetition-Lag Memory Training is Feasible in Patients with Chronic Stroke Patients, Including Those with Memory Problems. Brain Injury, 31(1), 57-67. (on-line 23 November 2016).  http://www.tandfonline.com/doi/full/10.1080/02699052.2016.1222081  PMID: 27880059    

26. Patel, V.P., Zambrana, A., Walker, L.A.S., Herrmann, H. & Feinstein, A. (2017).  Distraction adds to the cognitive burden in multiple sclerosis.  Multiple Sclerosis Journal, 23(1), 106-113.  (online 24 March 2016)  DOI: 10.1177/1352458516641208  PMID: 27012660  

27. Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar-Or, A., Bence-Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Heubsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O’Connor, P., Ramsay, T., Sabloff, M., Walker, L.A.S. & Freedman, M.S. (2016; 6-12 Aug).  Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial.  The Lancet, 388 (10044), 576-585, (online 9 June 2016) http://dx.doi.org/10.1016/S0140-6736(16)30169-6  PMID: 27291994

28. Walker, L.A.S., Berard, J.A., Bowman, M., Atkins, H.L., Lee, H., Arnold, D. & Freedman, M.S. (2016).  Longitudinal change in PASAT performance following immunoablative therapy and haematopoietic stem cell transplant in multiple sclerosis.  Multiple Sclerosis and Demyelinating Disorders, 1:12, DOI:10.1186/s40893-016-0014-y

29. Patel, V.P., Zambrana, A., Walker, L.A.S., Herrmann, N., Swartz, R. & Feinstein, A. (2016).  Distractibility in multiple sclerosis: the role of depression.  Multiple Sclerosis Journal: Experimental, Translational and Clinical, 2, 1-5.  DOI: 10.1177/2055217316653150  PMID: 28607730  

30. Walker, L.A.S., Osman, L., Berard, J.A., Rees, L.M, Freedman, M.S., MacLean, H. & Cousineau, D. (2016).  Brief International Cognitive Assessment for MS (BICAMS): Canadian contribution to the international validation project.  Journal of the Neurological Sciences, 362, 147-152.  doi:10.1016/j.jns.2016.01.040  PMID: 26944137  

31. Stamenova, V., Jennings, J.M., Cook, S.P., Walker, L.A.S., Smith, A.M. & Davidson, P.S.R. (2014).  Training Recollection in Healthy Older Adults: Clear Improvements on the Training Task, but Little Evidence of Transfer.  Frontiers in Psychology, 8, 1-13.  doi: 10.3389/fnhum.2014.00898  PMID: 25477801 (Corrigendum doi:10.3389/fnhum.2015.00658  PMID: 26648862)   

32. Berard, J.A., Walker, L.A.S., Smith, A.M. & Freedman, M.S. (2014).  Longitudinal comparison of desktop and fMRI scanner versions of the Computerized Test of Information Processing in Multiple Sclerosis: A pilot study.  Journal of Multiple Sclerosis, 2(2).  http://dx.doi.org/10.4172/jmso.1000121  

33. Berrigan, L.I., Fisk, J.D., Walker, L.A.S., Wojtowicz, M., Rees, L.M., Freedman, M.S. & Marrie, R-A. (2014).  Reliability of Regression-Based Normative Data for the Oral Symbol Digit Modalities Test: An Evaluation of Demographic Influences, Construct Validity, and Impairment Classification Rates in Multiple Sclerosis Samples.  The Clinical Neuropsychologist, 28(2), 281-99.  http://dx.doi.org/10.1080/13854046.2013.871337  PMID: 24438521  

34. Berard, J.A., Bowman, M., Atkins, H.L., Freedman, M.S. & Walker, L.A.S. (2014).  Cognitive fatigue in individuals with multiple sclerosis undergoing immunoablative therapy and haematopoietic stem cell transplantation. Journal of the Neurological Sciences, 336, 132-137. http://dx.doi.org/10.1016/j.jns.2013.10.023  PMID: 24189209  
35. Walker, L.A.S., Berard, J.A., Atkins, H.L., Bowman, M., Lee, H. & Freedman, M.S. (2014).  Cognitive change and neuroimaging following immunoablative therapy and hematopoietic stem cell transplantation in multiple sclerosis: A pilot study.  Multiple Sclerosis and Related Disorders, 3, 129-135. http://dx.doi.org/10.1016/j.msard.2013.05.001  PMID: 25877984  

36. Berrigan, L.I., LeFevre, J., Rees, L.M., Walker, L.A.S., Berard, J. & Freedman, M.S. (2013).  Cognition in early relapsing-remitting multiple sclerosis: Consequences may be relative to working memory.  Journal of the International Neuropsychological Society, 19(8), 938-949.  http://dx.doi.org/10.1017/S1355617713000696  PMID: 23866100  

37. Walker, L.A.S., Berard, J., Berrigan, L.I., Rees, L.M. & Freedman, M.S. (2012). Detecting cognitive fatigue in multiple sclerosis: Method matters.  Journal of the Neurological Sciences, 316, 86-92. doi:10.1016/j.jns.2012.01.021.  PMID: 22336698  

38. Walker, L.A.S., Cheng, A., Berard, J., Berrigan, L.I., Rees, L.M. & Freedman, M.S. (2012).  Tests of information processing speed: What do people with multiple sclerosis think about them?  International Journal of MS Care, 14, 92-99. (article won Herndon Award for Outstanding International Journal of MS Care Article for best article published in 2012)  doi: 10.7224/1537-2073-14.2.92. PMID: 24453739  

39. Smith, A.M., Walker, L.A.S., Freedman, M.S., Berrigan, L.I., St. Pierre, J., Hogan, M. & Cameron, I. (2012).  Activation Patterns in Multiple Sclerosis on the Computerized Tests of Information Processing: Speed and Task Matter.  Journal of the Neurological Sciences, 312, 131-137. doi: 10.1016/j.jns.2011.08.003  PMID: 21862036  

40. Walker, L.A.S., Mendella, P.D., Stewart, A., Freedman, M.S. & Smith, A.M (2011).  Meaningful change in cognition in MS: Method matters.  Canadian Journal of Neurological Sciences, 38, 282-288.  DOI: 10.1017/s0317167100011471  PMID: 21320834  

41. Tombaugh, T. N., Berrigan, L. I., Walker, L.A.S.  & Freedman, M. S. (2010).  The Computerized Tests of Information Processing (CTIP) Offers an Alternative to the PASAT for Assessing Cognitive Processing Speed in Individuals with Multiple Sclerosis.  Cognitive and Behavioral Neurology, 23(3), 192-198.  DOI: 10.1097/WNN.0b013e3181cc8bd4  PMID: 20829669  

42. Smith, A.M., Walker, L.A.S., Freedman, M.S., DeMeulemeester, C., & Hogan, M. (2009).  fMRI investigation of disinhibition in cognitively impaired patients with multiple sclerosis.  Journal of the Neurological Sciences, 281, 58-63.  Published on-line (doi:10.1016/j.jns.2009.02.366).  PMID: 19344919  

43. Walker, L. & DeMeulemeester, C. (2008).  Spontaneous intracranial hypotension masquerading as frontotemporal dementia.  The Clinical Neuropsychologist, 22, 1035-1053. doi: 10.1080/13854040701874386  PMID: 18609334  

44. Reicker, L. I., Tombaugh, T. N., Walker, L., Freedman, M. S. (2007).  Reaction Time:  An alternative method for assessing the effects of multiple sclerosis on information processing speed.  Archives of Clinical Neuropsychology, 22, 655-664.  https://doi.org/10.1016/j.acn.2007.04.008  PMID: 17532182

PubMed Listings

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