Seminars & Events

Tuesday, December 02, 2025, 13:00-14:00
The Neuroscience Program presents
x-synuclein tetramer abrogation: biochemically advanced PD mouse models with implications in lipid metabolism and estrogen-pathways
Speaker: Silke Nuber, PhD
Associate Professor, Dept of Neurology Ann Romney Center for Neurologic Diseases Brigham and Women''s Hospital
Harvard Medical School
Location: Hybrid In Person RGN Room 2003 and ZOOM
Please contact Nancy MacDonald at nmacdonald@toh.ca for the link
Hosted by Dr. Michael Schlossmacher

Learning Objectives

1. Abrogating physiological a-synuclein tetramers produces neuropathology and a progressive motor syndrome resembling PD, including partial protection by female sex based on synaptic estrogen receptor availability
2. Distinct a-synuclein mutations causing graded solubility can impact synaptic function and motor skill learning abilities
3. Increasing certain membrane phospholipid saturation improve the a-synuclein physiological state in vivo and may guide the development of PD therapeutic approaches.

Please note that OHRI seminars are open to all members of OHRI and partner institutions. Members of the general public are asked to contact the communications office (jganton@ohri.ca) for more information about the research presented at OHRI seminars.