Senior Scientist, Inflammation & Chronic Disease
Ottawa Hospital Research Institute

Professor, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine
University of Ottawa

Professor, Department of Medicine, Faculty of Medicine
University of Otawa

HIV immunopathogenesis
Immune based therapies for HIV Infection

http://www.cancurehiv.org/

Dr. Angel graduated from medical school at the University of Toronto in 1988, which was followed by an internal medicine residency in Toronto. After one year as the chief medical resident at St. Paul&rsquos Hospital in Vancouver, he did his clinical and research infectious diseases training at the New England Medical Center/Tufts University in Boston. In 1995, Dr. Angel joined the Division of Infectious Diseases, Department of Medicine at the Ottawa General Hospital. Since that time he has been involved in laboratory based and clinical research as well as teaching and patient care. His research is focused on understanding how HIV damages the immune system and how these insights can potentially lead to new therapies. Dr. Angel is currently a Professor of Medicine at the University of Ottawa, a Senior Scientist in the Ottawa Hospital Research Institute and Head of the Division of Infectious Diseases.

- N. Ranganath, T.S. Sandstrom, S.C. Burke Schinkel, S.C. Cote, J.B. Angel. “The Oncolytic Virus MG1 Targets and Eliminates Cells Latently Infected with HIV-1: Implications for an HIV Cure.” J Infect Dis. 217(5):721-730, Feb 2018.

- T.S. Sandstrom, N. Ranganath, S.C. Burke Schinkel, S. Salahuddin, O. Meziane, S.C. Coté, C. Costiniuk, M-A. Jenabian, J.B. Angel. “HIV-Infected Macrophages Are Infected and Killed by the Interferon-Sensitive Rhabdovirus MG1.” J. Virol. 95(9):e01953-20, Apr 2021.

- A. Vera-Cruz, N. Tanphaichitr, J.B. Angel. “Antimicrobial Peptide, LL-37, and its Potential as an Anti-HIV Agent.” Clin Invest Med. 44(3):E64-71, Oct 2021.

- B. Molyer, A. Kumar, J.B. Angel. “SMAC Mimetics as Therapeutic Agents in HIV infection.” Front Immunol. 12:780400, Nov 2021.

- S.G. Lee, W. Kiattiburut, S.C. Burke Schinkel, J.B. Angel, N. Tanphaichitr. "Safety of multiple administrations of spermicidal LL-37 antimicrobial peptide into the mouse female reproductive tract." Mol Hum Reprod. 2023 Jun 30;29(7):gaad023, June 2023.

HIV; Infectious disease

Basic research; Clinical research; Translational research