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Leo Renaud, BA, MD, PhD, FRCPC, FRSC



Selected Publications

A perspective of the research in the Renaud lab.
On the neurophysiology and neuropharmacology of central regulatory mechanisms
This lab has fostered a longstanding interest in CNS regulation of neuroendocrine and autonomic functions, hydromineral and cardiovascular homeostasis, stress and arousal. In-vivo and in-vitro investigations in rodent models have sought to characterize aspects of the cellular neurobiology engaged in these functions. Key publications include: RENAUD & BOURQUE, Prog Neurobiol 36: 131-169, 1991 (a review focused on hypothalamic magnocellular neurosecretory neurons); HERMES et al., J Physiol 496:749-757, 1996; ZHANG et al., Neuroscience 141: 2059-2066, 2006 (rapid neurotransmission from the suprachiasmatic nucleus to hypothalamic neuroendocrine and pre-autonomic neurons, and to midline thalamus); WILSON et al., J Physiol 545: 945-960, 2002; WHYMENT et al., Neuroscience 178: 68-81, 2011 (intrinsic properties of spinal sympathetic preganglionic neurons); KOLAJ et al., Front Behav Neurosci Volume 8, Article 132, 2014 (a review of properties and pharmacology unique to thalamic midline paraventricular neurons).

On centrally acting neuropeptides
Following their structural characterization, the initial availability of hypothalamic releasing factors TRH, LHRH and somatostatin permitted in-vivo evaluation of their actions on a variety of CNS neurons (e.g. RENAUD et al., Nature 255: 233-235, 1975; RENAUD et al., Science 205: 1275-1277, 1979), adding support for the notion that peptides participated in neural communication either as slowly acting neurotransmitters or as modulators. Subsequent investigations in-vitro with patch clamp recording techniques allowed more detailed investigations into mechanisms of action of various neuropeptides in the hypothalamus e.g. YANG et al., Am J Physiol 263: R1333-R1338, 1992; BAI & RENAUD, Am J Physiol 275: R632-R639, 1998; HERMES et al., J Neurophysiol 102: 1834-1842, 2009 (angiotensin, vasoactive intestinal peptide), spinal cord e.g. KOLAJ & RENAUD., J Neurophysiol 80: 1900-1910, 1998; OZ et al., J Neurophysiol 94: 1405-1412, 2005 (TRH, vasopressin and angiotensin on ventral horn neurons), midline thalamus e.g. ZHANG et al., Am J Physiol 290: R1226-R1232, 2006; KOLAJ et al., Neuroscience 147: 1066-1075, 2007; DOROSHENKO & RENAUD, Neuroscience 158: 1560-1570, 2009; HERMES et al., J Physiol 591: 1823-1839, 2013; ZHANG et al., Neurophyarmacology 72:106-115, 2013 (vasopressin, orexins, gastrin releasing peptide, TRH).

PubMed Listings

For more publications use this PubMed ID link.