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Mouse study further supports role of muscle stem cells in Duchenne muscular dystrophy
March 13, 2025
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“This study confirms that we’ll need to target both muscle fibres and muscle stem cells in order to treat this disease."
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ELEVATE seed grants help researchers at The Ottawa Hospital launch new ideas and collaborations
March 3, 2025
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The grants, worth a total of $198,000, will advance research on muscle disease, stroke, ovarian cancer and scleroderma.
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New Canada Research Chairs to advance regenerative medicine, thrombosis and stroke research at The Ottawa Hospital
November 14, 2024
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The federal government announced a new round of Canada Research Chairs this week, including three based at The Ottawa Hospital.
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$2.8M grant to support Canada-wide trial of cell therapy for preterm babies
September 16, 2024
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“This trial could change the way we care for premature babies. It’s my hope that these tiny patients will have a better chance to thrive, grow up, and have an impact on the world around them."
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Clinical trial to test muscular dystrophy therapy developed at The Ottawa Hospital
September 10, 2024
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Researchers at The Ottawa Hospital, the University of Ottawa and Satellos Bioscience have developed an innovative regenerative therapy for Duchenne muscular dystrophy (DMD) that is now being tested in people as part of a world-first clinical trial.
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Satellos Bioscience wins top company award and rings TSX bell
May 24, 2024
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Satellos Bioscience, a start-up company founded by Dr. Michael Rudnicki, received the prestigious Company of the Year Award from Life Sciences Ontario and opened the Toronto Stock Exchange last week.
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Study reveals molecular reason why arteries harden with age
May 14, 2024
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“These cells could help us uncover potential drugs to prevent or treat cardiovascular diseases by targeting these molecular changes."
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Two decades in the making — world-first trial aims to heal the lungs of preemies
May 1, 2024
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Emmy Cogan entered this world weighing barely more than a pound. This tiny warrior made history by becoming the first baby in North America to receive a world-first cell therapy trial to heal the lungs of preterm babies
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Are EVs travelling to injured lungs?
March 15, 2024
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Tiny particles called extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have shown clear potential to treat several lung diseases in animal models by reducing inflammation. However, there has been debate about where MSC-EVs end u
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ELEVATE seed grants to help researchers at The Ottawa Hospital improve treatment for inflammatory and immune conditions
February 21, 2024
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The Ottawa Hospital’s Research Institute is awarding four ELEVATE seed grants to help researchers understand the role of inflammation and the immune system in various diseases and develop better treatments.
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Tiny trailblazer: First baby treated in world-first trial for chronic lung disease
January 19, 2024
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Emmy Cogan was the first baby treated in a world-first clinical trial of a cell therapy for bronchopulmonary dysplasia.
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New scientist profile: Dr. Blair Gage uses stem cell biology to build blood vessels and develop new treatments
January 2, 2024
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As a self-proclaimed “cell therapist,” Dr. Blair Gage aims to understand what makes stem cells tick and then gently coax them to realize their full potential.
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Powering up the body’s EVs
November 9, 2023
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Dr. Alvin Tieu is receiving the Worton Researcher in Training Award from The Ottawa Hospital for his multidisciplinary research on life-threatening lung diseases
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Tiny Cells for Tiny Lungs
September 28, 2023
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“Stem cells used to be something that were grown in a petri dish. They are now game-changing therapies with live-saving potential for even the tiniest of patients.”
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Engineered lung tissue model reveals possible new treatment for lymphangioleiomyomatosis
July 12, 2023
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A research team led by Dr. Bill Stanford has discovered a new class of drugs that may be effective in treating lymphangioleiomyomatosis (LAM). This rare disease is characterized by abnormal cell growth in the lungs which can lead to severe breathing
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Start-up company raises $55M to fuel development of new therapy for Duchenne muscular dystrophy
June 8, 2023
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Satellos Bioscience, a start-up company founded by Dr. Michael Rudnicki, has closed $55 million in financing to support the development of its lead drug candidate for Duchenne muscular dystrophy.
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Novel stem cell drives ‘remarkable’ regeneration of tiny blood vessels in the lung
May 15, 2023
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Dr. Duncan Stewart’s team has identified a novel stem cell with a remarkable ability to regenerate and repair the tiny blood vessels in the lungs.
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First patient treated in world-first cell therapy trial to heal the lungs of preterm babies
March 23, 2023
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Researchers have treated the first patient in an innovative clinical trial of a cell therapy that aims to prevent very premature babies from developing a chronic lung disease called bronchopulmonary dysplasia (BPD). This is the first trial of its kin
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‘Cord blood cells are priceless for us’
March 1, 2023
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Cord blood donors help fuel Dr. William Stanford’s research and bring hope to leukemia patients
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ELEVATE seed grants to help researchers at The Ottawa Hospital develop better treatments and improve patient care
February 1, 2023
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The Ottawa Hospital’s Research Institute is awarding five ELEVATE seed grants to early-career researchers to spur the development of innovative treatments and better patient care.
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Clinical trial will test promising cell therapy for septic shock
January 19, 2023
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Dr. Lauralyn McIntyre was awarded $1.6 million from the Canadian Institutes of Health Research Clinical Trials Fund to conduct a Phase II clinical trial of mesenchymal stem cells (MSCs) in patients with septic shock.
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Saviour siblings: surprising discovery reveals the staying power of stem cells from older brothers
December 14, 2022
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The researchers believe this is the first example of this kind of “saviour sibling” effect to rescue a lethal genetic deficit.
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Huge hope for our smallest patients
November 2, 2022
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Dr. Bernard Thébaud clearly remembers the day he decided to become a doctor—his dad had suggested the soccer-loving teen become a sports physician. But from the first day of his pediatric surgery rotation, Dr. Thébaud knew he wanted to help
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Research reveals novel mechanism controlling muscle stem cells
October 5, 2022
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New research from Dr. Michael Rudnicki’s team shows for the first time that a cellular structure called a primary cilium, which functions somewhat like an antenna, plays a crucial role in priming muscle stem cells for repair and regeneration.
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Soccer skills and stem cell science- Meet Dr. Bernard Thébaud
September 14, 2022
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Every day, Dr. Bernard Thébaud creates futures for Ottawa’s youngest community members. As a senior scientist with the Ottawa Hospital Research Institute, and as a neonatologist with the Children’s Hospital of Eastern Ontario (CHEO), Dr. Thé
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MS stem cell transplant gives priceless second chance
September 1, 2022
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Thanks to a life-changing stem cell transplant at The Ottawa Hospital, Geneviève Bétournay has a whole new perspective on the possibilities that lie ahead for her.
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Hyaluronic acid, a naturally occurring compound, awakens stem cells to repair damaged muscle
August 4, 2022
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A new study published in the journal Science reveals a unique form of cell communication that controls muscle repair.
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“Dream team” of researchers tackles leading cause of vision loss
July 27, 2022
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Dr. Catherine Tsilfidis has assembled a world-class team to bring discoveries with game-changing potential to patients with retinal disease
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Lab-grown “mini-kidneys” unlock secrets of a rare disease
July 21, 2022
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Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumours in patients with tuberous sclerosis complex (TSC).
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Researchers at The Ottawa Hospital awarded 19 CIHR grants worth more than $12 million
July 20, 2022
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These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, muscle
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Dr. Michael Rudnicki admitted as a Fellow of the Royal Society
June 22, 2022
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Dr. Michael Rudnicki has been formally admitted as a Fellow of the Royal Society, the world’s oldest and most prestigious scientific institution. He is one of only 12 Canadians to be admitted.
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Ottawa Hospital researchers awarded $1.85M from Stem Cell Network
May 12, 2022
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Four research teams at The Ottawa Hospital have been awarded a total of $1.85 million to harness stem cells and regenerative medicine to develop new therapies for septic shock, bone and joint conditions, and newborn lung damage, while also advancing
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Meet brain and eye researcher Dr. Pierre Mattar
April 25, 2022
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Dr. Pierre Mattar is doing the groundwork needed to develop treatments for vision loss
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Nano therapy for micro-preemies protects lungs, brain in lab study
March 30, 2022
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Very premature babies need extra oxygen and mechanical intervention to breathe, but this damages their lungs, causing a chronic lung disease called bronchopulmonary dysplasia (BPD).
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Tiny particles hold promise for treating acute and chronic lung disease
February 17, 2022
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A meta-analysis of lab studies found that tiny particles called extracellular vesicles (EVs) released by mesenchymal stem/stromal cells (MSCs) have clear potential for treating acute lung injury,
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Researchers at The Ottawa Hospital awarded 18 CIHR grants worth more than $11 million
February 5, 2022
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These projects will advance science and improve health in areas such as tuberculosis, blood disease, prostate cancer, heart disease, muscle repair, sleep apnea, brain cancer, medical imaging, virtual care, prehab, intellectual disability, sarcoma, CA
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From baseball stats wiz to game-changing epigenetic scientist
November 15, 2021
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Meet Dr. Jeff Dilworth — winner of Chrétien Researcher of the Year Award
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Supercharging stem cells
November 12, 2021
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Dr. Jeff Dilworth is receiving The Ottawa Hospital’s Chrétien Researcher of the Year Award for his groundbreaking research, which could bring new energy to exhausted stem cells and help them repair the body
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$2.4 M grant to help researchers develop gene and cell therapies for a leading cause of blindness
September 15, 2021
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A team led by Dr. Catherine Tsilfidis has received $2.4 M from the Ontario Research Fund to develop treatments for retinal diseases, a leading cause of blindness.
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Research unravels links between fasting, lifespan and muscle stem cells
June 2, 2021
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Intermittent fasting (or skipping meals) has often been reported to increase lifespan in various animals, but the observation that it also affects muscle stem cell function has been less well-studied.
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Researchers at The Ottawa Hospital awarded three grants for high risk, high reward and interdisciplinary research
May 31, 2021
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The New Frontiers in Research Fund (NFRF) 2020 Exploration competition brings diverse disciplines together in pursuit of breakthrough ideas and high-reward outcomes.
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Biotherapeutics: the future of medicine
May 25, 2021
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World-class biotherapeutics facility at The Ottawa Hospital uses cells, genes and viruses to create unique life-saving treatments
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Stem cell treatment for scleroderma improves quality of life
February 17, 2021
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When Dr. Nancy Maltez meets a patient with early severe systemic scleroderma, a rare autoimmune disease that hardens the skin and organs, she knows one of the best options is to reset their immune system using strong chemotherapy and a stem cell tran
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$1M investment fuels development of new therapies for Duchenne muscular dystrophy
February 1, 2021
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Parent Project Muscular Dystrophy has invested $1M in Satellos Bioscience, a startup company founded by Dr. Michael Rudnicki.
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Can a diabetes drug help repair damaged nerve insulation? Mouse study shows it might.
January 27, 2021
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A study in mice led by Dr. Jing Wang suggests that the diabetes drug metformin may be able to repair damage to nerve insulation caused by diseases like MS and stroke.
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Dr. Eve Tsai and Dr. Adam Sachs work in very different ways to improve the lives of people with spinal cord injury
December 11, 2020
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Research studies at The Ottawa Hospital offer promise and hope
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Using lab-grown human tissues to identify possible treatments
June 8, 2020
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Dr. William Stanford and his colleagues are using human tissue models to understand why COVID-19 makes some patients severely ill.
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Experimental Stem Cell Therapy a Potential Weapon in COVID-19 Fight
May 28, 2020
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Ottawa-based researchers pivot at lightning speed to launch study on treating related respiratory failure
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Mysteries of cell fate unlocked with new measurement and modeling techniques
May 14, 2020
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Drs. Marjorie Brand, Ted Perkins and Jeffrey Ranish have found a missing link needed to fully understand how stem cells become specialized cells.
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Dr. Michael Rudnicki elected into the Royal Society
April 29, 2020
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Dr. Michael Rudnicki has been elected a Fellow of the Royal Society, the most prestigious and oldest scientific institution in the world. Dr. Rudnicki is an internationally recognized thought leader in molecular genetics and regenerative medicine.
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Researchers use lab-grown human tissues to understand secrets of COVID-19 infection, identify possible treatments
April 29, 2020
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A team of Ontario researchers is using 3D lab-grown human tissue models to understand why COVID-19 makes some patients severely ill. They also hope to identify drugs that can reduce the severity of the infection.
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Harnessing stem cells and regenerative medicine to fight COVID-19
April 23, 2020
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Researchers from The Ottawa Hospital and the University of Ottawa have been awarded $490,000 from the Stem Cell Network for two research projects that could help in the fight against COVID-19. These peer-reviewed grants are part of an overall investm
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Stem cells may heal lungs of premature babies
March 4, 2020
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Premature babies need extra oxygen and mechanical intervention to breathe but this can damage their lungs, causing a chronic lung disease. A stem cell treatment soon to be tested in clinical trials at The Ottawa Hospital may help heal the lungs of pr
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New method can help labs around the world grow stem cells more efficiently
January 15, 2020
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Researchers from Dr. William Stanford’s lab have developed a more efficient way to grow all kinds of cells from induced pluripotent stem cells (iPSCs).
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How does a stem cell know what to be when it grows up?
October 22, 2019
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Dr. Marjorie Brand has been hooked on research ever since her training as a biochemistry student in France, where she discovered a new set of proteins that can turn genes on in the cell. This early success motivated the senior scientist at The Ottawa
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The Ottawa Hospital awarded 13 grants worth $11.2 million from Canadian Institutes of Health Research
July 26, 2019
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Researchers at The Ottawa Hospital have been awarded 13 grants worth a total of $11.2 million from the Canadian Institutes of Health Research (CIHR). The new projects focus on areas such as cancer immunotherapy, hepatitis C infection, blood clots, ar
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$950,000 to help develop stem cell treatments for septic shock, lung injury and muscle degeneration
May 17, 2019
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Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks to four new peer-reviewed research grants from the Ontario Institute for Regenerative Medici
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Breakthrough reveals how a stem cell decides between two fates
March 29, 2019
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Dr. Marjorie Brand’s team discovered how a blood stem cell decides whether to become a red blood cell or a platelet-forming cell in a new study published in Cell Stem Cell. By using a technique that measures tiny amounts of proteins in individual cel
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Autologous hematopoietic stem cell transplantation recommended as a standard of care for certain kinds of MS in the U.S.
March 13, 2019
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The American Society for Blood and Marrow Transplantation has recommended that stem cell transplantation for MS, which has been pioneered at The Ottawa Hospital, be considered a “standard of care, clinical evidence available” for people with certain
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Targeting cancer stem cells improves survival in certain kinds of colorectal cancer
August 16, 2018
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An international clinical trial led by Dr. Derek Jonker found that a drug that targets cancer stem cells improved survival in patients with a specific form of colorectal cancer. Cancer stem cells make up a very small part of a some tumours. However,
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Using stem cells to treat brain cancer: pilot study highlights potential new approach
August 16, 2018
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Stem cells are usually associated with repairing damaged tissue and treating degenerative diseases, but they also have a unique property that may be harnessed to fight cancer. When injected into the body, stem cells naturally migrate to tumours, and
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Diabetes drug could enhance stem cell treatment for stroke
August 8, 2018
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Imagine removing blood or skin cells from a patient after a stroke, turning them into powerful stem cells in the lab, and then transplanting them back into the same patient's brain so they can give rise to new neurons to repair the damage. This is th
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Stem cell researchers tackle muscle weakness in older people
May 30, 2018
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For most people, muscle loss is a normal part of aging that makes daily tasks harder. Muscle loss called sarcopenia happens more quickly, leading to falls and decreased mobility. One reason for this muscle loss is that stem cells that help repair dam
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Discovery provides “profound new insight” into Duchenne muscular dystrophy
April 19, 2018
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Researchers at The Ottawa Hospital and the University of Ottawa have discovered a completely new function for the protein complex containing the dystrophin protein, which is missing in people with Duchenne muscular dystrophy. Dr. Michael Rudnicki and
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