StemCore Laboratories

Akuma, M. (2025). Characterization of Dysregulated VHL-Mediated pRb Regulation in Clear Cell Renal Cell Carcinoma [PhD Thesis, Université d’Ottawa/University of Ottawa]. 

Clémot-Dupont, S., Lourenço Fernandes, J. A., Larrigan, S., Sun, X., Medisetti, S., Stanley, R., El Hankouri, Z., Joshi, S. V., Picketts, D. J., Shekhar, K., & Mattar, P. (2025). The chromatin remodeler ADNP regulates neurodevelopmental disorder risk genes and neocortical neurogenesis. Proceedings of the National Academy of Sciences, 122(3), e2405981122. 

Cober, N. D., McCourt, E., Godoy, R. S., Deng, Y., Schlosser, K., Qamsari, E. S., Azami, J., Salehisiavashani, E., Cook, D. P., & Lemay, S.-E. (2025). Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension. Cardiovascular Research, 121(13), 2095–2112. 

Esper, M. E., Lin, A. Y., Bennett, D., & Rudnicki, M. A. (2025). Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis. Nature Communications, 16(1), 10031. 

Jahan, S., Maganti, H. B., Patel, J., Pasha, R., Doxtator, E., Manesia, J. K., & Pineault, N. (2025). Reduction in cord blood graft potency due to processing delay can be prevented by trehalose supplementation. Vox Sanguinis, vox.70012. 

Jo, D.-H. (2025). Innovative Approaches to Natural Killer Cell Engineering: Overcoming Challenges in CRISPR-Cas9 Genome Editing, Transgene Expression, and Cryopreservation [PhD Thesis, Université d’Ottawa/University of Ottawa]. 

Jo, D.-H., Kaczmarek, S., Khan, A. U. H., Pervin, J., Clark, D. M., Gadde, S., Wang, L., McComb, S., Visram, A., & Lee, S.-H. (2025). Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression. Frontiers in Immunology, 16, 1533044. 

Larrivée, M. (2025). Generating CAR γδ T Cells for Effective Targeting of B Lymphomas [PhD Thesis, Université d’Ottawa| University of Ottawa]. 

Losier, T. T., King, K. E., Rousseaux, M. W., & Russell, R. C. (2025). Identification of organelle-specific autophagy regulators from tandem CRISPR screens. Journal of Cell Biology, 224(10), e202405138.

Martell, E., Kuzmychova, H., Senthil, H., Chawla, U., Kaul, E., Grewal, A., Banerji, V., Anderson, C. M., Venugopal, C., & Miller, D. (2025). Disease stage-specific role of the mitochondrial pyruvate carrier suppresses differentiation in temozolomide and radiation-treated glioblastoma. Neuro-Oncology, noaf008. 

Noblett, N. (2025). Exploring the Role for IPPK-1 and PAL-1 in the Genetic Landscape of C. elegans Ventral Nerve Cord Assembly [PhD Thesis, Université d’Ottawa| University of Ottawa]. 

Noblett, N., Roenspies, T., Flibotte, S., & Colavita, A. (2025). Nuclear hormone receptor regulation of Caudal mediates ventral nerve cord assembly in C. elegans. bioRxiv

Parweez, F., Palou, R., Li, R., Kadhim, L., MacMillan, H., Tyers, M., & Johné Liu, X. (2025). Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster. bioRxiv

Shah, S., Lourenço Fernandes, J. A., Medisetti, S., & Mattar, P. (2025). Chd4 remodels chromatin to control retinal cell type specification and lineage termination. bioRxiv

Zuccarini, R. (2025). The Effect of Sox9 on Cell Growth and Stemness in HER2-Positive Breast Cancer [PhD Thesis, Université d’Ottawa/University of Ottawa]. 

Angka, L., Tennakoon, G., Cook, D. P., Martel, A. B., Market, M., de Souza, C. T., Cummins, E., Samudio, I., Kekre, N., & Ardolino, M. (2024). Preventing surgery induced immune suppression and metastases by inhibiting PI3K-gamma signalling in Myeloid-Derived Suppressor Cells. bioRxiv

Bergin, C. J., Zouggar, A., Mendes da Silva, A., Fenouil, T., Haebe, J. R., Masibag, A. N., Agrawal, G., Shah, M. S., Sandouka, T., Tiberi, M., Auer, R. C., Ardolino, M., & Benoit, Y. D. (2024). The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors. Nature Cancer. 

Bhattarai, K. R. (2024). Deciphering the Role of ARK5 and hnRNP A1 in Regulating the Osmotic Stress. [PhD Thesis, Carleton University].

Clemot-Dupont, S., Fernandes, J. A. L., Larrigan, S., Sun, X., Medisetti, S., Stanley, R., El Hankouri, Z., Joshi, S. V., Picketts, D. J., & Shekhar, K. (2024). The ChAHP chromatin remodelling complex regulates neurodevelopmental disorder risk genes to scale the production of neocortical layers. bioRxiv

Cyr-Depauw, C., Cook, D. P., Mižik, I., Lesage, F., Vadivel, A., Renesme, L., Deng, Y., Zhong, S., Bardin, P., Xu, L., Möbius, M. A., Marzahn, J., Freund, D., Stewart, D. J., Vanderhyden, B. C., Rüdiger, M., & Thébaud, B. (2024). Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells. American Journal of Respiratory and Critical Care Medicine.

Gatica, D., Alsaadi, R. M., El Hamra, R., Mueller, R., Miyazaki, M., Sad, S., & Russell, R. (2024). The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection. bioRxiv

Kalinina, A. (2024). The Differential Regulation of Adult Neural Stem Cells by Beclin1 and Atg5 [PhD Thesis, Université d’Ottawa/University of Ottawa]. 

Kalinina, A., Dhaliwal, J., Xue, Y., Vaculik, M., McCambley, M., Fong, B. C., Cook, D., Slack, R. S., & Lagace, D. C. (2024). Mitotic Activity and DNA Maintenance of Adult Neural Stem Cells is Regulated by Beclin1. bioRxiv

Kornfeld, S. F., Cummings, S. E., Yaworski, R., De Repentigny, Y., Gagnon, S., Zandee, S., Fathi, S., Prat, A., & Kothary, R. (2024). Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination. Communications Biology, 7(1), 813. 

Leung, J. W.-H., Loan, A., Xu, Y., Yang, G., Wang, J., & Chan, H. M. (2024). Reduction of Glyoxalase 1 Expression Links Fetal Methylmercury Exposure to Autism Spectrum Disorder Pathogenesis. Toxics, 12(7), Article 7. 

Li, J., Vranjkovic, A., Read, D., Delaney, S. P., Stanford, W. L., Cooper, C. L., & Crawley, A. M. (2024). Lasting differential gene expression of circulating CD8 T cells in chronic HCV infection with cirrhosis identifies a role for Hedgehog signaling in cellular hyperfunction. Frontiers in Immunology, 15.

Loan, A., Awaja, N., Lui, M., Syal, C., Sun, Y., Sarma, S. N., Chona, R., Johnston, W. B., Cordova, A., & Saraf, D. (2024). Single-cell profiling of brain pericyte heterogeneity following ischemic stroke unveils distinct pericyte subtype-targeted neural reprogramming potential and its underlying mechanisms. Theranostics, 14(16), 6110. 

Losier, T. T., Rousseaux, M. W., & Russell, R. C. (2024). Identification of stress specific autophagy regulators from tandem CRISPR screens. bioRxiv

Molyer Yildirir, B. (2024). SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death [PhD Thesis, Université d’Ottawa | University of Ottawa]. 

Peneycad, C. J. (2024). The splicing inhibitor isoginkgetin induces transcription of metallothionein genes through the metal responsive transcription factor MTF-1 [PhD Thesis, Carleton University]. 

ProProwse, N. (2024). The Truncated Tropomyosin Kinase B Receptor Influences Feeding Behaviour, Cholesterol Production and Susceptibility to Stress in a Sex-Dependent Manner [PhD Thesis, Carleton University]. 

Prykhozhij, S. V., Ban, K., Brown, Z. L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., & Midgen, C. (2024). miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics, 20(5), e1011290. 

Rodriguez, G. M., Yakubovich, E., Maranda, V., Hanna, A. M. R., & Vanderhyden, B. C. (2024). NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens. Frontiers in Immunology, 14. 

Russell, R., Akuma, M., Kim, M., Zhu, C., Wiljer, E., Gaudreau-Lapierre, A., Patterson, L., Trinkle-Mulcahy, L., Stanford, W. L., & Riazalhosseini, Y. (2024). Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma. bioRxiv

Suk, T. R., Part, C. E., Nguyen, T. T., Zhang, J. L., Heer, M. M., Caballero-Gomez, A., Grybas, V. S., McKeever, P. M., Nguyen, B., & Callaghan, S. M. (2024). A stress-dependent TDP-43 SUMOylation program preserves neuronal function. bioRxiv