Many prostate cancer patients saved from unnecessary treatments and side effects
February 29, 2016
Low-risk patients increasingly undergoing regular monitoring rather than immediate treatment
Of the approximately 24,000 Canadians diagnosed with prostate cancer each year, about half have a slow-growing form that poses little risk to their health. A new study from The Ottawa Hospital and the University of Ottawa shows that men with these slow-growing tumours are increasingly avoiding unnecessary and potentially harmful treatment in favour of an approach called active surveillance – monitoring the cancer with regular tests and treating it only if it changes to a higher risk form.
This kind of surveillance for low risk prostate cancer has recently been recommended by Cancer Care Ontario. This paper, published in the Canadian Medical Association Journal, is the first comprehensive study to describe how often surveillance is being performed in Canada.
The research team reviewed the medical records of 477 men with low-grade prostate cancer referred to The Ottawa Hospital’s Ages Cancer Assessment Clinic between 2008 and 2013. They found that the number of patients under active surveillance increased dramatically from 32 percent in 2008 to 68 percent in 2013. They also found that after five years of follow-up, about 59% of the patients under active surveillance were still being managed that way.
“Recent data suggest that low-grade prostate cancer can grow very slowly, and therefore many patients likely don’t need treatment at all,” said Dr. Rodney Breau, senior author of the study and a prostate cancer surgeon and epidemiologist at The Ottawa Hospital and the University of Ottawa. “Some men can go for years, or maybe their entire lives, without the cancer spreading. If we monitor patients closely, we can still treat the cancer if it becomes higher risk. If the cancer doesn’t progress, they can avoid unnecessary surgery, radiation and other therapies, which can have side effects including incontinence, impotence and bowel problems.”
One man who was able to avoid this kind of unnecessary treatment is Stephen Wilson, a 56-year-old dairy plant manager in Winchester, Ontario. When he was diagnosed with low-grade prostate cancer in December 2012, both his oncologist in Cornwall and Dr. Breau recommended that he go on active surveillance.
“Whenever you hear the ‘c’ word, panic sets in,” said Wilson. “You have to live with the notion that it’s there, but I have a background in science which allowed me do that without any problems. Now it’s been three years and I’m good; active surveillance has been the right choice for me.”
Dr. Breau notes that the study confirms that being diagnosed with prostate cancer does not necessarily mean a man will need treatment. This means that doctors can maintain the benefits of prostate cancer screening while reducing a potential harm – the overtreatment of slow-growing tumours. In addition, the study found that among the patients who received treatment, almost all did so because of a change in their cancer, not because of anxiety.
The researchers also note that the active surveillance rate observed in the study is much higher than estimated surveillance rates during the same time period in the United States.
“Many patients are now avoiding unnecessary treatment, and this represents a major paradigm shift in the management of this disease,” said lead author Dr. Octav Cristea, a urology resident at The Ottawa Hospital and the University of Ottawa. “With more studies like ours coming out, I hope that active surveillance will become the global standard for patients with low-grade prostate cancer.”
Full reference: “Active Surveillance in Canadian Men Diagnosed with Low Grade Prostate Cancer.” CMAJ.Octav Cristea, Luke T. Lavallée, Joshua Montroy, Andrew Stokl, Sonya Cnossen, Ranjeeta Mallick, Dean Fergusson, Franco Momoli, Illias Cagiannos, Christopher Morash, Rodney H. Breau.Feb. 29, 2016.
Funders: This study did not have dedicated funding. However, Dr. Breau is supported by a Research Chair in Urologic Oncology funded by The Ottawa Hospital Foundation.
Video: Dr. Breau speaking about what motivates his research.
About The Ottawa Hospital: The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See www.ohri.ca for more information about research at The Ottawa Hospital.
About the University of Ottawa: The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca
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