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Research connecting two rare but deadly neurological diseases
January 28, 2015
Dr.
Rashmi Kothary
has been awarded $390,000 from
E-Rare
, via the Canadian Institutes of Health Research, to explore the role of a protein called Fas in the neuron cell death found in ALS and in spinal muscular atrophy (SMA), an incurable paralytic neuromuscular disorder that mainly affects children. Fas is known to contribute to the loss of motor neurons in ALS. Dr. Kothary's team has now shown that high levels of Fas are also found in the neurons of SMA mouse models. He will be joining teams from France and Switzerland to develop gene therapy approaches that reduce Fas activity, with the aim of generating common therapies for ALS, SMA and other motor neuron diseases. See
details
.
About the Ottawa Hospital Research Institute
The
Ottawa Hospital Research Institute
is the research arm of
The Ottawa Hospital
and is an affiliated institute of the
University of Ottawa
, closely associated with its faculties of Medicine and Health Sciences. The Ottawa Hospital Research Institute includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting research to improve the understanding, prevention, diagnosis and treatment of human disease. Support our research. Give to the
Tender Loving Research
campaign.
Media contact
Paddy Moore
Communications and Public Relations
Ottawa Hospital Research Institute
613-737-8899 x73687
613-323-5680 (cell)
padmoore@ohri.ca