Skip over navigation
The Hospital
Research
Support Us
Ottawa Hospital Research Institute
Home
Français
Directions & Maps
Contact Us
About Us
Vision and Strategic Directions
Board Chair and CEO Message
Leadership Team
Annual Reports
Facilities
Research Data Management
Equity, Diversity and Inclusion
Wellness
Our Research
Priorities, Programs and Diseases
Researcher Profiles
National Research Networks
Scientific Publications
Research Awards
Technology Transfer
Industry Sponsored Research
Responsible Innovation
For Students & Fellows
News & Events
Newsroom
Seminars & Events
Career Opportunities
For Patients
News & Events
Home
>
News & Events
>
Newsroom
Bookmark or Share
Display Options
Display Options
+
Increase
/
-
Decrease
font size
High contrast version
Printer-friendly version
Newsroom
Seminars & Events
Newsroom
Taking the Trojan horse to the next level: using fruit fly cells to deliver viral therapies for cancer
December 8, 2015
Oncolytic viruses destroy cancer cells without harming normal cells, but once an immune response develops against a given virus, it can become more difficult for subsequent doses of virus to get through the blood stream and into tumours. One possible solution developed by Dr.
John Bell
’s group involves using fruit fly cells as “Trojan horses” to carry oncolytic viruses through the blood and into tumours. A recent study led by PhD student Dominic Roy shows that the strategy works well in mouse models of cancer. The infected insect cells can travel through the blood without significantly stimulating the immune system, and substantially reduce the tumour burden. Importantly, the system allows for multiple oncolytic viruses and gene therapies to be delivered at the same time. See the
Journal of Controlled Release
for details.
Authors:
D.G. Roy, A.T. Power, M.C. Bourgeois-Daigneault T. Falls, Ferreira, A. Sterna, C. Tanese de Souza, J.A. McCart, D.F. Stojdl, B.D. Lichty, H. Atkins, R.C. Auer, J.C. Bell, F. Le Boeuf.
Funders:
Terry Fox Research Institute, Canadian Institutes of Health Research, Ontario Institute for Cancer Research, The Ottawa Hospital Foundation.
About The Ottawa Hospital
The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care.
For further information, please contact
Jennifer Ganton
Director, Communications and Public Relations
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73325
Cell: 613-614-5253
jganton@ohri.ca