main research interest is the regulation of gene expression at the level of
transcription and chromatin / epigenetic. We are using a combination of in
(proteomics, genomics) and in vivo
(leukemia mice models,
xenotransplantation of human leukemic cells in immunodeficient mice) approaches
to understand how hematopoietic stem cells differentiate into blood cells and
how deregulation of this process causes leukemia. Recently, we have also developed
an interest in understanding the regenerative properties of endothelial
stem/progenitor cells in vascular repair.
Marjorie Brand Lab Website
C.G. Palii, B. Vulesevic, S.
Fraineau, E. Pranckeviciene, A.J. Griffith, A. Chu, H.
Faralli, Y. Li, B. McNeill, J. Sun, T.J. Perkins, F.J. Dilworth, C. Perez-Iratxeta, E.J. Suuronen, D.S. Allan & M.
Brand. Trichostatin A enhances vascular repair by injected human
endothelial progenitors through increasing the expression of TAL1-dependent genes.
Cell Stem Cell, 14(5): 644-657, 2014
C-P. Chaturvedi, B. Somasundaram, K. Singh, R.L. Carpenedo, W.L. Stanford, F.J.
Dilworth & M. Brand. Maintenance
of gene silencing by the coordinate action of the H3K9 methyltransferase
G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proceedings of the National Academy of Sciences USA, 109 (46): 18845-50, 2012
Palii*, C. Perez-Iratxeta*, Z. Yao, Y. Cao, F. Dai, J. Davison, H.
Atkins, D. Allan, F.J. Dilworth, R. Gentleman, S. Tapscott & M. Brand. Differential genomic targeting of the transcription
factor TAL1 in alternate hematopoietic lineages. The EMBO Journal, 30 (3):
Chaturvedi*, A.M. Hosey*, C. Palii, C. Perez-Iratxeta, Y.
Nakatani, J.A. Ranish, F.J. Dilworth & M.
Brand. Dual role for the methyltransferase G9a in
the maintenance of ß-globin gene transcription in adult erythroid cells. Proceedings
of the National Academy of Sciences, 106 (43): 18303-18308, 2009
C. Demers, C-P. Chaturvedi,
J. A. Ranish, G. Juban, P. Lai, F. Morle, R. Aebersold, F. Dilworth, M.
Groudine and M. Brand. Activator-mediated
Recruitment of the MLL2 Methyltransferase Complex to the ß-globin Locus. Molecular Cell, 27: 573-584, 2007