Marjorie Brand profile picture

Contact Information

Marjorie Brand, PhD
613-737-7700 ext 70336
mbrand@ohri.ca

What We Do

Our main research interest is the regulation of gene expression at the level of transcription and chromatin / epigenetic. We are using a combination of in vitro (proteomics, genomics) and in vivo (leukemia mice models, xenotransplantation of human leukemic cells in immunodeficient mice) approaches to understand how hematopoietic stem cells differentiate into blood cells and how deregulation of this process causes leukemia. Recently, we have also developed an interest in understanding the regenerative properties of endothelial stem/progenitor cells in vascular repair.

Marjorie Brand Lab Website

Selected Publications

A. Benyoucef, C.G. Palii, C. Wang, C.J. Porter, A. Chu, F. Dai, V. Tremblay, P. Rakopoulos, K. Singh, S. Huang, F. Pflumio, J. Hebert, J-F. Couture, T.J. Perkins, K. Ge, F.J. Dilworth & M. Brand. UTX inhibition as a selective epigenetic therapy against TAL1-driven T cell acute lymphoblastic leukemia. Genes & Development, 30(5): 508-521, 2016

C.G. Palii, B. Vulesevic, S. Fraineau, E. Pranckeviciene, A.J. Griffith, A. Chu, H. Faralli, Y. Li, B. McNeill, J. Sun, T.J. Perkins, F.J. Dilworth, C. Perez-Iratxeta, E.J. Suuronen, D.S. Allan & M. Brand. Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes. Cell Stem Cell, 14(5): 644-657, 2014

C-P. Chaturvedi, B. Somasundaram, K. Singh, R.L. Carpenedo, W.L. Stanford, F.J. Dilworth & M. Brand. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proceedings of the National Academy of Sciences USA, 109 (46): 18845-50, 2012

C.G. Palii*, C. Perez-Iratxeta*, Z. Yao, Y. Cao, F. Dai, J. Davison, H. Atkins, D. Allan, F.J. Dilworth, R. Gentleman, S. Tapscott & M. Brand. Differential genomic targeting of the transcription factor TAL1 in alternate hematopoietic lineages. The EMBO Journal, 30 (3): 494-509, 2011  * contributed equally

C-P. Chaturvedi*, A.M. Hosey*, C. Palii, C. Perez-Iratxeta, Y. Nakatani, J.A. Ranish, F.J. Dilworth & M. Brand. Dual role for the methyltransferase G9a in the maintenance of ß-globin gene transcription in adult erythroid cells. Proceedings of the National Academy of Sciences, 106 (43): 18303-18308, 2009 * contributed equally

C. Demers, C-P. Chaturvedi, J. A. Ranish, G. Juban, P. Lai, F. Morle, R. Aebersold, F. Dilworth, M. Groudine and M. Brand. Activator-mediated Recruitment of the MLL2 Methyltransferase Complex to the ß-globin Locus.  Molecular Cell, 27: 573-584, 2007

Meet the Brand Lab