Bernard Thebaud profile picture

Contact Information

Bernard Thebaud, MD, PhD
613-737-8899 ext 73905
bthebaud@ohri.ca

ORCID logo https://orcid.org/0000-0003-1844-7145

What We Do

Our lab is focused on understanding the mechanisms of lung development, injury and repair in order to design new treatments for incurable lung diseases. We have an ambitious research program set out to study clinically relevant questions in the lab for translation into real-life applications. All animal models of human lung disease are available in our lab, and we correlate structural and functional changes to assess the clinical relevance of the experimental therapies we are testing.

Over the past 10 years, our major research contributions include: (i) the discovery of the role of angiogenesis for normal lung development and repair; (ii) the demonstration of the therapeutic potential of stem cells in experimental bronchopulmonary dysplasia (the chronic lung disease of prematurity), asthma, acute lung injury and pulmonary hypertension; and more recently, (iii) the therapeutic potential of adeno-associated virus (AAV)-mediated gene therapy for surfactant protein deficiency.

Over the next five years, our goal is the safe and timely translation of effective cell- and gene-based therapies for lung diseases into the clinic, thereby creating vast improvements in patient outcomes.

Selected Publications

Hurskainen M, Mizikova I, Cook DP, Andersson N, Cyr-Depauw C, Lesage F, Helle E, Renesme L, Jankov RP, Heikinheimo M, Vanderhyden BC, Thébaud B. Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage. Nat Commun. 2021 Mar 10;12(1):1565.

Thébaud B
, Lalu M, Renesme L, van Katwyk S, Presseau J, Thavorn K, Cobey KD, Hutton B, Moher D, Soll RF, Fergusson D. Benefits and obstacles to cell therapy in neonates: The INCuBAToR (Innovative Neonatal Cellular Therapy for Bronchopulmonary Dysplasia: Accelerating Translation of Research). Stem Cells Transl Med. 2021 Feb 11. doi: 10.1002/sctm.20-0508.

Kang MH, van Lieshout LP, Xu L, Domm JM, Vadivel A, Renesme L, Mühlfeld C, Hurskainen M, Mizikova I, Pei Y, van Vloten JP, Thomas SP, Milazzo C, Cyr-Depauw C, Whitsett JA, Nogee LM, Wootton SK, Thébaud B. A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency. Nat Commun. 2020 Aug 6;11(1):3929.

Augustine S, Cheng W, Avey MT, Chan ML, Lingappa SMC, Hutton B, Thébaud B. Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia: concise review. Stem Cells Transl Med. 2020 Feb;9(2):158-168.

Thébaud B, Goss KN, Laughon M, Whitsett JA, Abman SH, Steinhorn RH, Aschner JL, Davis PG, McGrath-Morrow SA, Soll RF, Jobe AH. Bronchopulmonary Dysplasia. Nat Rev Dis Primers. 2019 Nov 14;5(1):78.

Guillot M, Asad S, Lalu MM, Lemyre B, Castillo G, Thébaud B, Presseau J. So you want to give stem cells to babies? Neonatologists and parents’ views to optimize clinical trials. J Pediatr. 2019 Jul;210;41-47.

Augustine S, Avey MT, Harrison B, Locke T, Ghannad M, Moher D, Thébaud B. Mesenchymal stromal cell therapy in bronchopulmonary dysplasia: systematic review and meta-analysis of preclinical studies. Stem Cell Transl Med. 2017 Dec;6(12):2079-2093.

Zhu Y, Xu L, Collins JJP, Vadivel A, Cyr-Depauw C, Zhong S, Mense L, Möbius MA, Thébaud B. Human umbilical cord mesenchymal stromal cells improve survival and bacterial clearance in neonatal sepsis in rats. Stem Cells Dev. 2017 Jul 15;26(14):1054-1064.

Alphonse RS, Vadivel A, Zhong S, McConaghy S, Ohls R, Yoder MC, Thébaud B. A method to isolate and culture lung vascular endothelial colony-forming cells. Nat Protoc. 2015 Nov;10(11):1697-708.

Alphonse RS, Vadivel A, Fung M, Shelley WC, Critser PJ, Ionescu L, O’Reilly M, Ohls RK, McConaghy S, Eaton F, Zhong S, Yoder M, Thébaud B. Existence, functional impairment and lung repair potential of endothelial colony forming cells in oxygen-induced arrested alveolar growth. Circulation. 2014 May 27;129(21):2144-57.

Pierro M, Ionescu L, Montemurro T, Vadivel A, Weissmann G, Oudit G, Emery D, Bodiga S, Eaton F, Péault B, Mosca F, Lazzari L, Thébaud B. Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax. 2013 May;68(5):475-84.

Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL,? Thébaud B. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation. 2011 May 17;123(19):2120-31.

van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, GJ Rey-Parra, Bouchentouf M, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med. 2009; 180(11):1131-42.

Thébaud B, Ladha F, Michelakis E, Sawika M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL. Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 2005 Oct 18;112(16):2477-86. 

Meet the Xplore Lab


Staff:
Arul Vadivel, Senior Research Associate
Martin Kang, Senior Research Associate
Liqun Xu, Senior Research Technician
Shumei Zhong, Research Technician

Trainees:
Pauline Bardin, Postdoctoral Fellow
Ewa Henckel, Postdoctoral Fellow
Flore Lesage, Postdoctoral Fellow
Chanèle Cyr-Depauw, PhD candidate
Adithya Achuthan Karikandathil Vineeth, MSc candidate
Kennedy Nangle, MSc candidate
Kiran Singh, MSc candidate
Alexandra Cerchez, Undergraduate student
Brynn Perreault, Undergraduate student
Janani Ramamurthy, Undergraduate MD student