Our lab is focused on understanding the mechanisms of lung development, injury and repair in order to design new treatments for incurable lung diseases. We have an ambitious research program set out to study clinically relevant questions in the lab for translation into real-life applications. All animal models of human lung disease are available in our lab, and we correlate structural and functional changes to assess the clinical relevance of the experimental therapies we are testing.
Our major research contributions over the past seven years include (i) the discovery of the role of angiogenesis in normal lung development and repair, and (ii) the demonstration of the therapeutic potential of stem cells in experimental bronchopulmonary dysplasia, asthma, chronic obstructive pulmonary disease, and pulmonary hypertension.
Over the next five years, our goal is to bring safe and effective cell-based therapies for lung diseases into the clinic, and thereby create vast improvements in patient outcomes.
Alphonse RS, Vadivel A, Fung M, Shelley WC, Critser PJ, Ionescu L, O'Reilly M, Ohls RK, McConaghy S, Eaton F, Zhong S, Yoder M, Thébaud B
. Existence, functional impairment and lung repair potential of endothelial colony forming cells in oxygen-induced arrested alveolar growth. Circulation
. 2014 May 27;129(21):2144-57.
Pierro M, Ionescu L, Montemurro T, Vadivel A, Weissmann G, Oudit G, Emery D, Bodiga S, Eaton F, Péault B, Mosca F, Lazzari L, Thébaud B
. Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax
. 2013 May;68(5):475-84. doi: 10.1136/thoraxjnl-2012-202323.
Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL, Thébaud B
. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation
. 2011 May 17;123(19):2120-31.
van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, GJ Rey-Parra, Bouchentouf M, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B
. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med
. 2009; 180(11):1131-42.
, Ladha F, Michelakis E, Sawika M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL. Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation
. 2005 Oct 18;112(16):2477-86.