Carolyn Nessim profile picture

Contact Information

Carolyn Nessim, MD, MSc, FRCSC, FACS
613-737-8899 ext 71085

Fax: 613-737-8659

Carolyn Nessim

Clinician Investigator, Cancer Therapeutics Program
Ottawa Hospital Research Institute
Surgical Oncologist, Division of General Surgery
The Ottawa Hospital
Assistant Professor of Surgery, Department of Surgery
The University of Ottawa
Program Director, Surgical Oncology Fellowship Program
The University of Ottawa

Research Interests

Dr. Carolyn Nessim's main research interests involve evaluating neo-adjuvant approaches to locally advanced and resectable oligometastic melanoma using combinations of targeted and immunotherapy and identifying biomarkers of clinical response. She also collaborates with scientists at OHRI being involved in the evaluation of response to various cancer treatments on ex-vivo melanoma, sarcoma and GIST cells. Currently she is collaborating on a project evaluating the use of oncolytic viruses in the treatment of melanoma and soft tissue sarcoma. She also focuses on outcomes research evaluating quality measures in the diagnosis and treatment of Melanoma and Soft Tissue Sarcoma/GIST and is a member of the Trans-Atlantic Retro-Peritoneal Sarcoma Working Group (TARPSWG). She is also an active member of the Ontario Cancer Research Ethics Board (OCREB).

Brief Biography

Dr. Carolyn Nessim is a Surgical Oncologist at the Ottawa Hospital and Assistant Professor of Surgery at the University of Ottawa. She is currently the Program Director for the Surgical Oncology subspecialty Fellowship training program. Her clinical practice focuses on the treatment of patients with Melanoma and other skin cancers as well as Soft Tissue Sarcoma/GIST and Gastric cancer. She is a Clinician Investigator in the Cancer Therapeutic Program (CTP) at the Ottawa Hospital Research Institute (OHRI). She did her MD and General Surgery Residency at the University of Montreal.  She then completed her MSc in Biomedical Sciences creating a pCR kit for the prediction of hormone therapy in Breast Cancer at the University of Montreal.  Her fellowship training was in Surgical Oncology at the University of Toronto and then at the Peter MacCallum Cancer Center in Melbourne Australia.

Selected Publications

Trans-Atlantic Retroperitoneal Sarcoma Working Group (Gronchi A, Swallow C, Nessim C. et al.) Management of Recurrent Retroperitoneal Sarcoma (RPS) - A Consensus Approach from the Trans-Atlantic RPS Working Group. April 2016 In press Ann Surg Onc 2016

Tsvetkova E, Marginean C with Nessim C and Verma S. Gastrointestinal Stromal Tumor (GIST) – Paving the Way for Modern Oncology – Epidemiology, Diagnosis, Treatment. Oncology and Hematology Review 2015, In Print

Nessim C, Law C, McConnell Y, Shachar S, McKinnon G, Wright F. How often do Level III nodes bear melanoma metastases and does it affect patient outcomes? Ann Surg Oncol 2013 ; 20(6) :2056-64. doi : 10.1245/s10434-013-2880-2

Nessim C, Winocour J, Holloway D., Holloway C. Wait times for Breast Cancer Surgery: Impact of the Diagnostic Pathway. J Onc Prac 2015; DOI: 10.1200/JOP.2014.002105

Nessim C, Bensimon C, Hales B, Laflamme C, Fenech D, Smith A. Surgical Site Infection Prevention: A qualitative analysis on an individualized audit and feedback model. J Am Coll Surg 2012; 215(6):850-7. doi: 10.1016/j.jamcollsurg.2012.08.007.

Nessim C, Sidéris L, Turcotte S, Vafiadis P, Lapostole AC, Simard S, Koch P, Fortier LP, Dubé P. The effect of fluid overload in the presence of an epidural on the strength of colonic anastomoses. J Sur Res 2013; 183(2):567-79. doi: 10.1016/j.jss.2013.03.030

Nessim C, Ferguson P, Gupta A, Catton C, Gladdy R. Retroperitoneal and Extremity Soft Tissue Sarcoma. Chapter in the Toronto Surgical Oncology Manual 1st edition, published in April 2012.

Nessim C, Govidarajan A, McCart A. Peritoneal Malignancies. Chapter in the Toronto Surgical Oncology Manual 1st edition, published in April 2012.

Nessim C, Rotstein L, Goldstein D, Sun A, Hogg D, McCready D, Ghazarian D. Princess Margaret Hospital: Melanoma Guidelines, PMH website, June 2012.

Diseases, conditions and populations of interest

Cancer; Colorectal cancer; Gastric cancer; Gastrointestinal disease; Gastrointestinal stromal tumours (GIST); Skin cancer; Soft tissue sarcoma

Research and clinical approaches

Biomarkers; Clinical research; Clinical trials; Gene expression; Immunotherapy; Immunotherapy; Surgery; Translational research; Viral therapy