Lacoste Lab

Baptiste Lacoste profile picture

Contact Information

Baptiste Lacoste, PhD
613-562-5800 Ext. 7124
blacoste@uottawa.ca

What We Do

Studying neuro-vascular interactions is essential to gain a better understanding of brain and mind health. Indeed, the brain is highly dependent on a steady supply of blood, which carries oxygen and nutrients, and therefore this noble organ is particularly vulnerable to inherited and acquired cerebrovascular failures. 

Over the years, Dr. Lacoste has developed an expertise focused on elucidating the mechanisms of cerebrovascular network formation, function, and remodeling in various health and disease contexts. From the Lacoste lab we investigate 1) how cerebrovascular networks form properly after birth, 2) what mechanisms underlie their plasticity, 3) how their integrity is altered in neurological conditions, and 4) how targeting cerebrovascular remodeling may offer innovative therapeutic options throughout life.

Ultimately, identifying key cellular and molecular mediators of cerebrovascular plasticity will lead to important findings about structural and functional determinants of vascular health, an essential pre-requisite for the development of transformative strategies for neuroprotection.

Selected Publications

Toussay X., Tiberi M., and Lacoste B. (2018) Laser doppler flowmetry to study the regulation of cerebral blood flow by G protein-coupled receptors in rodents. Methods Mol Biol.  [in press]

Sadeghian H., Lacoste B., Qin T., Toussay X., Rosa R., Chung D.Y., Oka F, Takizawa T., Gu C., and Ayata C. (2018). Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis. Annals of Neurology, 84(3):409-423.

Gouveia A.,  Seegobin M.,  Kannangara T.S.,  He L., Wondisford F.,  Comin C.H.,  Costa L.DaF, Béïque J.C.,  Lagace D.C.,  Lacoste B.,  and Wang J. (2017) The  aPKC-CBP  Pathway  Regulates Post-stroke  Neurovascular  Remodeling and Functional Recovery. Stem Cell Reports, 9(6):1735-1744.  

Almasi S., Xu X., Ben-Zvi A., Lacoste B., Gu C., Miller E. (2016). Joint volumetric extraction and enhancement of vasculature from low-SNR 3-D fluorescence microscopy images. Pattern Recognition, 63:710-18.

Lacoste B., Comin C.H., Ben-Zvi A., Kaeser P.S., Xu X., da F. Costa L., and Gu C. (2014) Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron, 83(5):1117-130.

Meet the Lacoste Lab

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In the Lacoste lab, we value a strong culture of collaboration, equity and generosity, as well as high standards in scientific quality and integrity. This philosophy, together with our multidisciplinary and integrative approaches, will be very beneficial for young scientists willing to engage themselves in a scientific career full of important discoveries related to brain health!

We strongly encourage energetic, inquisitive, enthusiastic, passionate students and fellows to apply! It could either be a short-term lab experience (co-op & summer students), a two-years inspiring research experience (master students), as well as a longer and exciting adventure (Ph.D. students, post-docs).