Michele Ardolino profile picture

Contact Information

Michele Ardolino, PhD
613-737-8899 ext 77257

What We Do

Selected Publications

1.   Ardolino M., Hsu J., Azimi C.S., Trevino T.N., Iannello A., Raulet D.H.  The checkpoint regulator PD-1 inhibits NK cell responses to tumors.  Manuscript in review.
2.  Ardolino M., Azimi C.S., Iannello A., Trevino T.N., Horan L., Zhang L., Deng W., Ring A. Fischer S., Garcia K.C., Raulet D.H. Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. The Journal of Clinical Investigation, 2014, 124 (11):4781-94
3.  Ardolino M., Zingoni A., Cerboni C., Cecere F., Soriani A., Iannitto M.L., Santoni A. DNAM-1 ligands expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T-cell interaction. Blood, 2011, 117 (18); 4778-86
4.  Iannello A., Thompson T.W., Ardolino M., Lowe S.W., Raulet D.H. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. The Journal of Experimental Medicine, 2013, 210 (10); 2057-69
5.  Shifrin N., Kissiov D.U.*, Ardolino M.*, Joncker N., Raulet D.H. Dissociation of tolerance and hyporesponsiveness of NK cells and differential roles of host cell types in imposing hyporesponsiveness.
The Journal of Immunology, 2016, 15; 197(10): 4127-4136
*Equal contribition

Meet the Cancer Immunology Lab

Young scientists are welcome to apply for a position as a master student, graduate student or post-doctoral fellow in the lab. A strong immunological background is not required, whereas applicants should be willing to work hard in a collaborative environment.

Guidelines to apply as a Graduate Student at the University of Ottawa: https://www.uottawa.ca/graduate-studies/programs-admission/apply.
Post-doctoral fellows are strongly encouraged to obtain independent funding during their first year of work in the lab.

Applications should include a resume and a short statement of research interest, clearly describing why the applicant wants to join the lab. At least two references should be sent independently to Dr. Ardolino (m.ardolino@uottawa.ca).